Zobrazeno 1 - 10 of 983 pro vyhledávání: '"Mach Robert H"'
2
Akademický článek
Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer
Autor: Hornick John R, Vangveravong Suwanna, Spitzer Dirk, Abate Carmen, Berardi Francesco, Goedegebuure Peter, Mach Robert H, Hawkins William G
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 31, Iss 1, p 41 (2012)
Abstract Background Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly understood, with varying
Externí odkaz: https://doaj.org/article/af5f810fd8344a0b9f6708077ac16cfa
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3
Akademický článek
Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
Autor: Han Byung, Zhou Meng-liang, Vellimana Ananth K, Milner Eric, Kim David H, Greenberg Jacob K, Chu Wenhua, Mach Robert H, Zipfel Gregory J
Publikováno v: Molecular Neurodegeneration, Vol 6, Iss 1, p 86 (2011)
Abstract Background Cerebral amyloid angiopathy (CAA) is characterized by deposition of fibrillar amyloid β (Aβ) within cerebral vessels. It is commonly seen in the elderly and almost universally present in patients with Alzheimer's Disease (AD). I
Externí odkaz: https://doaj.org/article/e56c23361e7b42a59cf2df288e65f9b7
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4
Akademický článek
The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine
Autor: Goedegebuure Peter, Spitzer Dirk, Mitchem Jonathan B, Tu Zhude, Vangveravong Suwanna, Xu Jinbin, Hornick John R, Mach Robert H, Hawkins William G
Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 298 (2010)
Abstract Background Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to
Externí odkaz: https://doaj.org/article/b71f817e0f2a4897a94924c9467bba7a
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5
Akademický článek
Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma
Autor: Chang Katherine, Vangveravong Suwanna, Goedegebuure Peter S, Simon Peter O, McDunn Jonathan E, Kashiwagi Hiroyuki, Hotchkiss Richard S, Mach Robert H, Hawkins William G
Publikováno v: Journal of Translational Medicine, Vol 7, Iss 1, p 24 (2009)
Abstract Background We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashion. Here, we examined
Externí odkaz: https://doaj.org/article/d2398f1453e84bf282707a41062ef9e0
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7
Akademický článek
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy
Autor: Johnston Fabian, Chang Katherine, Jones Lynne, Xu Jinbin, Goedegebuure Peter S, Simon Peter O, McDunn Jonathan E, Kashiwagi Hiroyuki, Trinkaus Kathryn, Hotchkiss Richard S, Mach Robert H, Hawkins William G
Publikováno v: Molecular Cancer, Vol 6, Iss 1, p 48 (2007)
Abstract Background Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-cancer therapeutics. The
Externí odkaz: https://doaj.org/article/9bac540b83e4481da9be07b3d8d7bcb7
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8
Akademický článek
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