Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Macfarlane, Fiona R"'
Derivation and travelling wave analysis of phenotype-structured haptotaxis models of cancer invasion
We formulate haptotaxis models of cancer invasion wherein the infiltrating cancer cells can occupy a spectrum of states in phenotype space, ranging from `fully mesenchymal' to `fully epithelial'. The more mesenchymal cells are those that display stro
Externí odkaz:
http://arxiv.org/abs/2310.19933
The capacity to aggregate through chemosensitive movement forms a paradigm of self-organisation, with examples spanning cellular and animal systems. A basic mechanism assumes a phenotypically homogeneous population that secretes its own attractant, w
Externí odkaz:
http://arxiv.org/abs/2206.14448
Existing studies comparing individual-based models of growing cell populations and their continuum counterparts have mainly focused on homogeneous populations, in which all cells have the same phenotypic characteristics. However, significant intercel
Externí odkaz:
http://arxiv.org/abs/2202.06583
Autor:
Hamis, Sara J, Macfarlane, Fiona R
Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by
Externí odkaz:
http://arxiv.org/abs/2008.04172
Since its introduction in 1952, Turing's (pre-)pattern theory ("the chemical basis of morphogenesis") has been widely applied to a number of areas in developmental biology. The related pattern formation models normally comprise a system of reaction-d
Externí odkaz:
http://arxiv.org/abs/2007.04195
We present a discrete model of chemotaxis whereby cells responding to a chemoattractant are seen as individual agents whose movement is described through a set of rules that result in a biased random walk. In order to take into account possible alter
Externí odkaz:
http://arxiv.org/abs/1912.07488
Rheumatoid arthritis is a chronic autoimmune disease that is a major public health challenge. The disease is characterised by inflammation of synovial joints and cartilage erosion, which leads to chronic pain, poor life quality and, in some cases, pr
Externí odkaz:
http://arxiv.org/abs/1911.09035
We give a very short introduction to discrete and continuum models for the evolutionary and spatial dynamics of cancer through two case studies: a model for the evolutionary dynamics of cancer cells under cytotoxic therapy and a model for the mechani
Externí odkaz:
http://arxiv.org/abs/1911.01865
Spatial interactions between cancer and immune cells, as well as the recognition of tumour antigens by cells of the immune system, play a key role in the immune response against solid tumours. The existing mathematical models generally focus only on
Externí odkaz:
http://arxiv.org/abs/1904.02979
Continuum models for the spatial dynamics of growing cell populations have been widely used to investigate the mechanisms underpinning tissue development and tumour invasion. These models consist of nonlinear partial differential equations that descr
Externí odkaz:
http://arxiv.org/abs/1812.05872