De-escalation from anti-CD20 to cladribine tablets in multiple sclerosis: A pilot study

Autor: Sacco, Rosaria, Disanto, Giulio, Pravatà, Emanuele, Mallucci, Giulia, Maceski, Aleksandra Maleska, Kuhle, Jens, Gobbi, Claudio, Zecca, Chiara

Publikováno v: In Multiple Sclerosis and Related Disorders December 2024 92

Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels Reflect Different Mechanisms of Disease Progression under B-Cell Depleting Treatment in Multiple Sclerosis.

Autor: Benkert P; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Maleska Maceski A; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Schaedelin S; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Oechtering J; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Zadic A; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Vilchez Gomez JF; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Melie-Garcia L; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland., Cagol A; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland., Galbusera R; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland., Subramaniam S; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Lorscheider J; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Galli E; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Mueller J; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland., Fischer-Barnicol B; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Achtnichts L; Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland., Findling O; Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland., Lalive PH; Department of Clinical Neurosciences, Division of Neurology, and Department of Medicine, Translational Biomarker Group, Geneva, Switzerland.; Diagnostic Department, Division of Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland.; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Bridel C; Department of Clinical Neurosciences, Division of Neurology, and Department of Medicine, Translational Biomarker Group, Geneva, Switzerland., Uginet M; Department of Clinical Neurosciences, Division of Neurology, and Department of Medicine, Translational Biomarker Group, Geneva, Switzerland., Müller S; Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Pot C; Service of Neurology and Laboratories of Neuroimmunology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Mathias A; Service of Neurology and Laboratories of Neuroimmunology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Du Pasquier R; Service of Neurology and Laboratories of Neuroimmunology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Salmen A; Department of Neurology, St Josef-Hospital Bochum, Ruhr-University Bochum, Bochum, Germany., Hoepner R; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Chan A; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Disanto G; Multiple Sclerosis Center, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland., Zecca C; Multiple Sclerosis Center, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland., D'Souza M; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Hemkens LG; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Yaldizli Ö; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Derfuss T; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Roth P; Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Gobbi C; Multiple Sclerosis Center, Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana (USI), Lugano, Switzerland., Brassat D; Novartis Pharma AG, Basel, Switzerland.; Department of Neurology, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Tackenberg B; Department of Neurology, Philipps-University, Marburg, Germany.; F. Hoffmann-La Roche, Basel, Switzerland., Pedotti R; F. Hoffmann-La Roche, Basel, Switzerland., Raposo C; F. Hoffmann-La Roche, Basel, Switzerland., Oksenberg J; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Hermesdorf M; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Piehl F; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Center for Neurology, Academic Specialist Center, Stockholm Health Services, Stockholm, Sweden., Conen D; Population Health Research Institute, McMaster University, Hamilton, Canada., Buser A; Regional Blood Transfusion Service, Swiss Red Cross, Basel, Switzerland., Kappos L; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Khalil M; Department of Neurology, Medical University of Graz, Graz, Austria., Granziera C; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINK) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland., Abdelhak A; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Leppert D; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Willemse EAJ; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland., Kuhle J; Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.

Publikováno v: Annals of neurology [Ann Neurol] 2024 Oct 16. Date of Electronic Publication: 2024 Oct 16.

Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms

Autor: Sonja M. Kagerer, Swapnil Awasthi, Stephan Ripke, Aleksandra Maceski, Pascal Benkert, Aïda B. Fall, Peter Riederer, Peter Fischer, Susanne Walitza, Edna Grünblatt, Jens Kuhle, Paul G. Unschuld

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)

Abstract INTRODUCTION Establishing valid diagnostic strategies is a precondition for successful therapeutic intervention in Alzheimer's disease (AD). METHODS One hundred forty‐four healthy 75‐year‐old participants from the Vienna‐Transdanube�

Externí odkaz: https://doaj.org/article/66b89bac42f44806ae6552cdfe03993b

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Neurofilament light chain plasma levels are associated with area of brain damage in experimental cerebral malaria

Autor: Chi Ho Wai, Jessica Jin, Marek Cyrklaff, Christel Genoud, Charlotta Funaya, Julia Sattler, Aleksandra Maceski, Stephanie Meier, Sabine Heiland, Michael Lanzer, Friedrich Frischknecht, Jens Kuhle, Martin Bendszus, Angelika Hoffmann

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Neurofilament light chain (NfL), released during central nervous injury, has evolved as a powerful serum marker of disease severity in many neurological disorders, including infectious diseases. So far NfL has not been assessed in cerebral m

Externí odkaz: https://doaj.org/article/9bc59db04d294d8c88bf7bb472b2285c