Allosteric regulation of epidermal growth factor (EGF) receptor ligand binding by tyrosine kinase inhibitors.

Autor: Macdonald-Obermann JL; From the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110., Pike LJ; From the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110 pike@biochem.wustl.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Aug 31; Vol. 293 (35), pp. 13401-13414. Date of Electronic Publication: 2018 Jul 11.

Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins.

Autor: Ronan T; From the Department of Biomedical Engineering and Center for Biological Systems Engineering and., Macdonald-Obermann JL; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110 and., Huelsmann L; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110 and., Bessman NJ; the Department of Biochemistry and Biophysics, Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104-6059., Naegle KM; From the Department of Biomedical Engineering and Center for Biological Systems Engineering and. Electronic address: knaegle@wustl.edu., Pike LJ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110 and. Electronic address: pike@biochem.wustl.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Mar 11; Vol. 291 (11), pp. 5528-5540. Date of Electronic Publication: 2016 Jan 19.

Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging.

Autor: Macdonald-Obermann JL; From the Departments of Biochemistry and Molecular Biophysics., Adak S; From the Departments of Biochemistry and Molecular Biophysics., Landgraf R; the Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33101., Piwnica-Worms D; Cell Biology and Physiology, and; Developmental Biology,; the Mallinckrodt Institute of Radiology, and; the Bridging Research with Imaging, Genomics and High Throughput Technologies Institute, Washington University School of Medicine, St. Louis, Missouri 63110 and., Pike LJ; From the Departments of Biochemistry and Molecular Biophysics,. Electronic address: pike@biochem.wustl.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Oct 18; Vol. 288 (42), pp. 30773-30784. Date of Electronic Publication: 2013 Sep 06.

Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.

Autor: Yang KS; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA., Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2010 Jul 30; Vol. 285 (31), pp. 24014-22. Date of Electronic Publication: 2010 May 27.

Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding.

Autor: Macdonald-Obermann JL; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8231, St. Louis, Missouri 63110, USA., Pike LJ

Publikováno v: Biochemistry [Biochemistry] 2009 Mar 24; Vol. 48 (11), pp. 2505-13.