Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.

Autor: Mercer SE; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Bristol Myers Squibb, Cambridge, MA 02142, United States. Electronic address: stephen.mercer@bms.com., Chaturvedula PV; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Spectrum Pharmaceuticals, Irvine, CA 92618, United States., Conway CM; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Biohaven Pharmaceuticals Inc., New Haven, CT 06510, United States., Cook DA; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Medtronic, North Haven, CT 06473, United States., Davis CD; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Amgen, Inc. Thousand Oaks, CA 91320, United States., Pin SS; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Cerevel Therapeutics Cambridge, MA 02141, United States., Macci R; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Thermo Fisher Scientific, Branford, CT 06405, United States., Schartman R; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Preformulation Solutions, LLC. North Ridgeville, OH 44039, United States., Signor LJ; Bristol-Myers Squibb, Wallingford, CT 06492, United States., Widmann KA; Bristol-Myers Squibb, Wallingford, CT 06492, United States., Whiterock VJ; Bristol-Myers Squibb, Wallingford, CT 06492, United States., Chen P; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Bristol Myers Squibb, Lawrenceville, NJ 08543, United States., Xu C; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Amgen, Inc. Thousand Oaks, CA 91320, United States., Herbst JJ; Bristol-Myers Squibb, Wallingford, CT 06492, United States., Kostich WA; Bristol-Myers Squibb, Wallingford, CT 06492, United States; National Multiple Sclerosis Society, New York, NY 10017, United States., Thalody G; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Preformulation Solutions, LLC. North Ridgeville, OH 44039, United States., Macor JE; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Sanofi, Waltham, MA 02451, United States., Dubowchik GM; Bristol-Myers Squibb, Wallingford, CT 06492, United States; Biohaven Pharmaceuticals Inc., New Haven, CT 06510, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jan 01; Vol. 31, pp. 127624. Date of Electronic Publication: 2020 Oct 21.

Multi-Class Imbalanced Data Handling with Concept Drift in Fog Computing: A Taxonomy, Review, and Future Directions.

Autor: Sharief, Farhana¹ (AUTHOR) farhana.shareef@uos.edu.pk, Ijaz, Humaira² (AUTHOR) humaira.bilalrasul@uos.edu.pk, Shojafar, Mohammad³ (AUTHOR) m.shojafar@surrey.ac.uk, Naeem, Muhammad Asif⁴ (AUTHOR) asif.naeem@nu.edu.pk

Publikováno v: ACM Computing Surveys. Jan2025, Vol. 57 Issue 1, p1-48. 48p.

Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.

Autor: Chaturvedula PV; Department of Molecular Sciences and Candidate Optimization, Bristol-Myers Squibb R&D, 5 Research Parkway, Wallingford, CT 06492, USA. Prasad.Chaturvedula@bms.com, Mercer SE, Pin SS, Thalody G, Xu C, Conway CM, Keavy D, Signor L, Cantor GH, Mathias N, Moench P, Denton R, Macci R, Schartman R, Whiterock V, Davis C, Macor JE, Dubowchik GM

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Jun 01; Vol. 23 (11), pp. 3157-61. Date of Electronic Publication: 2013 Apr 12.

The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.

Autor: Han X; Department of Molecular Sciences and Candidate Optimization (MSCO), Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, CT 06492, USA. xiaojun.han@bms.com, Civiello RL, Conway CM, Cook DA, Davis CD, Macci R, Pin SS, Ren SX, Schartman R, Signor LJ, Thalody G, Widmann KA, Xu C, Chaturvedula PV, Macor JE, Dubowchik GM

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jul 15; Vol. 22 (14), pp. 4723-7. Date of Electronic Publication: 2012 Jun 01.

Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.

Autor: Degnan AP; Department of Neuroscience Chemistry, Bristol-Myers Squibb Research & Development,Wallingford, Connecticut 06492, USA. andrew.degnan@bms.com, Chaturvedula PV, Conway CM, Cook DA, Davis CD, Denton R, Han X, Macci R, Mathias NR, Moench P, Pin SS, Ren SX, Schartman R, Signor LJ, Thalody G, Widmann KA, Xu C, Macor JE, Dubowchik GM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2008 Aug 28; Vol. 51 (16), pp. 4858-61. Date of Electronic Publication: 2008 Jul 30.