Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.

Autor: Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Suo S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Guangzhou Laboratory, Guangzhou, Guangdong 510005, China. Electronic address: suo_shengbao@gzlab.ac.cn., Wang Y; TScan Therapeutics, Waltham, MA 02451, USA., Gunasti L; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Nabilsi N; TScan Therapeutics, Waltham, MA 02451, USA., Tadros J; TScan Therapeutics, Waltham, MA 02451, USA., Ferretti AP; TScan Therapeutics, Waltham, MA 02451, USA., Liao S; TScan Therapeutics, Waltham, MA 02451, USA., Gurer C; TScan Therapeutics, Waltham, MA 02451, USA., Chen YH; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Criscitiello S; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Ricker CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Uppaluri R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA., Haddad RI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., MacBeath G; TScan Therapeutics, Waltham, MA 02451, USA., Schoenfeld JD; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: jonathan_schoenfeld@dfci.harvard.edu., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: kai_wucherpfennig@dfci.harvard.edu.

Publikováno v: Cell [Cell] 2022 Aug 04; Vol. 185 (16), pp. 2918-2935.e29. Date of Electronic Publication: 2022 Jul 07.

Phenotype, specificity and avidity of antitumour CD8 ⁺ T cells in melanoma.

Autor: Oliveira G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Stromhaug K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Klaeger S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kula T; TScan Therapeutics, Waltham, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA., Frederick DT; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Le PM; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Forman J; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Huang T; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Li S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Zhang W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Xu Q; TScan Therapeutics, Waltham, MA, USA., Cieri N; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Clauser KR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shukla SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Neuberg D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Justesen S; Immunitrack, Copenhagen, Denmark., MacBeath G; TScan Therapeutics, Waltham, MA, USA., Carr SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fritsch EF; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hacohen N; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Sade-Feldman M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Livak KJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Boland GM; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Ott PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. cwu@partners.org.; Harvard Medical School, Boston, MA, USA. cwu@partners.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. cwu@partners.org.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. cwu@partners.org.

Publikováno v: Nature [Nature] 2021 Aug; Vol. 596 (7870), pp. 119-125. Date of Electronic Publication: 2021 Jul 21.

Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities.

Autor: Zhu, Yingying¹ (AUTHOR) 20222013111295@stu.usc.edu.cn, He, Yajing¹ (AUTHOR), Gan, Runliang¹ (AUTHOR) ganrunliang@163.com

Publikováno v: Cells (2073-4409). Dec2024, Vol. 13 Issue 23, p1990. 19p.

A Self-Reference Interference Sensor Based on Coherence Multiplexing.

Autor: Shen, Ying¹ (AUTHOR), Huang, Zeyu¹ (AUTHOR), Huang, Feng¹ (AUTHOR), He, Yonghong² (AUTHOR), Ye, Ziling¹ (AUTHOR), Zhang, Hongjian¹ (AUTHOR), Guo, Cuixia¹ (AUTHOR) guocx@fzu.edu.cn

Publikováno v: Frontiers in Chemistry. 2024, p1-8. 8p.

Unbiased Screens Show CD8 ⁺ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.

Autor: Ferretti AP; TScan Therapeutics, Waltham, MA 02451, USA., Kula T; TScan Therapeutics, Waltham, MA 02451, USA., Wang Y; TScan Therapeutics, Waltham, MA 02451, USA., Nguyen DMV; TScan Therapeutics, Waltham, MA 02451, USA., Weinheimer A; TScan Therapeutics, Waltham, MA 02451, USA., Dunlap GS; TScan Therapeutics, Waltham, MA 02451, USA., Xu Q; TScan Therapeutics, Waltham, MA 02451, USA., Nabilsi N; TScan Therapeutics, Waltham, MA 02451, USA., Perullo CR; TScan Therapeutics, Waltham, MA 02451, USA., Cristofaro AW; TScan Therapeutics, Waltham, MA 02451, USA., Whitton HJ; TScan Therapeutics, Waltham, MA 02451, USA., Virbasius A; TScan Therapeutics, Waltham, MA 02451, USA., Olivier KJ Jr; TScan Therapeutics, Waltham, MA 02451, USA., Buckner LR; Ochsner Medical Center, New Orleans, LA 70121, USA., Alistar AT; Atlantic Health System, Morristown, NJ 07960, USA., Whitman ED; Atlantic Health System, Morristown, NJ 07960, USA., Bertino SA; TScan Therapeutics, Waltham, MA 02451, USA., Chattopadhyay S; TScan Therapeutics, Waltham, MA 02451, USA., MacBeath G; TScan Therapeutics, Waltham, MA 02451, USA. Electronic address: gmacbeath@tscan.com.

Publikováno v: Immunity [Immunity] 2020 Nov 17; Vol. 53 (5), pp. 1095-1107.e3. Date of Electronic Publication: 2020 Oct 20.