Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Macaulay IC"'
Autor:
Kirschner, K, Chandra, T, Kiselev, V, Flores-Santa Cruz, D, Macaulay, IC, Park, HJ, Li, J, Kent, DG, Kumar, R, Pask, DC, Hamilton, TL, Hemberg, M, Reik, W, Green, AR
Publikováno v:
Kirschner, K, Chandra, T, Kiselev, V, Flores-Santa Cruz, D, Macaulay, I C, Jun Park, H, Li, J, Kent, D G, Kumar, R, Pask, D C, Hamilton, T L, Hemberg, M, Reik, W & Green, A R 2017, ' Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment ', Cell Reports . https://doi.org/10.1016/j.celrep.2017.04.074
Cell Reports, Vol 19, Iss 8, Pp 1503-1511 (2017)
Cell Reports
Cell Reports, Vol 19, Iss 8, Pp 1503-1511 (2017)
Cell Reports
Summary Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct subpopulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d3695a633b40c444a9b434d42b1ecc
https://www.pure.ed.ac.uk/ws/files/37694463/Proliferation_drives_ageing_related_functional_decline_in_a_subpopulation_of_the_haematopoietic_stem_cell_compartment.pdf
https://www.pure.ed.ac.uk/ws/files/37694463/Proliferation_drives_ageing_related_functional_decline_in_a_subpopulation_of_the_haematopoietic_stem_cell_compartment.pdf
Autor:
Woll, PS, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, DC, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, AJ, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, IC, Clark, S-A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, MS, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, JE, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, SN, Nerlov, C, Nilsson, L, Campbell, PJ, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S, Jacobsen, SW
Publikováno v:
Woll, P S, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D C, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A J, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I C, Clark, S A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, M S, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J E, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, S N, Nerlov, C, Nilsson, L, Campbell, P J, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S & Jacobsen, S W 2014, ' Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo [Cancer Cell, 25 (2014) 794-808] ', Cancer Cell, vol. 25, no. 6 . https://doi.org/10.1016/j.ccr.2014.05.027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::396726e4222f40b51c19ecb438508d3e
https://pure.au.dk/portal/da/publications/erratum-to-myelodysplastic-syndromes-are-propagated-by-rare-and-distinct-human-cancer-stem-cells-in-vivo-cancer-cell-25-2014-794808(16bcc7e6-bbf9-4450-8177-5f97661a5eed).html
https://pure.au.dk/portal/da/publications/erratum-to-myelodysplastic-syndromes-are-propagated-by-rare-and-distinct-human-cancer-stem-cells-in-vivo-cancer-cell-25-2014-794808(16bcc7e6-bbf9-4450-8177-5f97661a5eed).html
Akademický článek
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Akademický článek
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Autor:
Carmona, SJ, Teichmann, SA, Ferreira, L, Macaulay, IC, Stubbington, MJT, Cvejic, A, Gfeller, D
The immune system of vertebrate species consists of many different cell types that have distinct functional roles and are subject to different evolutionary pressures. Here, we first analyzed conservation of genes specific for all major immune cell ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26bb23ee184f321cedfc84d37ebee751
Autor:
Bell AM; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.; Small Animal Clinical Sciences, School of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Utting C; Earlham Institute, Norwich NRU 7UZ, United Kingdom., Dickie AC; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Kucharczyk MW; The Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, United Kingdom.; Cancer Neurophysiology Group, Lukasiewicz-PORT, Polish Center for Technology Development, Wroclaw 54-066, Poland., Quillet R; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Gutierrez-Mecinas M; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Razlan ANB; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Cooper AH; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Lan Y; Earlham Institute, Norwich NRU 7UZ, United Kingdom., Hachisuka J; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Weir GA; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom., Bannister K; The Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, United Kingdom., Watanabe M; Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan., Kania A; Neural Circuit Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada., Hoon MA; Molecular Genetics Section, National Institute of Dental and Craniofacial Research/NIH, Bethesda, MD 20892., Macaulay IC; Earlham Institute, Norwich NRU 7UZ, United Kingdom., Denk F; The Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, United Kingdom., Todd AJ; Spinal Cord Group, School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2314213121. Date of Electronic Publication: 2024 May 28.
Autor:
Mok GF; School of Biological Sciences, University of East Anglia, Norwich, United Kingdom., Turner S; Earlham Institute, Norwich, United Kingdom., Smith EL; School of Biological Sciences, University of East Anglia, Norwich, United Kingdom., Mincarelli L; Earlham Institute, Norwich, United Kingdom., Lister A; Earlham Institute, Norwich, United Kingdom., Lipscombe J; Earlham Institute, Norwich, United Kingdom., Uzun V; Earlham Institute, Norwich, United Kingdom., Haerty W; Earlham Institute, Norwich, United Kingdom., Macaulay IC; Earlham Institute, Norwich, United Kingdom., Münsterberg AE; School of Biological Sciences, University of East Anglia, Norwich, United Kingdom.
Publikováno v:
Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 May 28; Vol. 12, pp. 1382960. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024).
Autor:
McGowan J; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Kilias ES; Department of Biology, University of Oxford, Oxford, United Kingdom., Alacid E; Department of Biology, University of Oxford, Oxford, United Kingdom., Lipscombe J; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Jenkins BH; Department of Biology, University of Oxford, Oxford, United Kingdom., Gharbi K; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Kaithakottil GG; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Macaulay IC; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., McTaggart S; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Warring SD; Earlham Institute, Norwich Research Park, Norwich, United Kingdom., Richards TA; Department of Biology, University of Oxford, Oxford, United Kingdom., Hall N; Earlham Institute, Norwich Research Park, Norwich, United Kingdom.; School of Biological Sciences, University of East Anglia, Norwich, United Kingdom., Swarbreck D; Earlham Institute, Norwich Research Park, Norwich, United Kingdom.
Publikováno v:
PLoS genetics [PLoS Genet] 2023 Oct 05; Vol. 19 (10), pp. e1010913. Date of Electronic Publication: 2023 Oct 05 (Print Publication: 2023).
Autor:
Luis TC; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK. t.luis@imperial.ac.uk.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK. t.luis@imperial.ac.uk.; Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, W12 0NN, London, UK. t.luis@imperial.ac.uk.; Department of Life Sciences, Imperial College London, SW7 2AZ, London, UK. t.luis@imperial.ac.uk., Barkas N; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Carrelha J; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Giustacchini A; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.; Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy., Mazzi S; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, SE-141 86, Stockholm, Sweden., Norfo R; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Wu B; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Aliouat A; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Guerrero JA; Department of Haematology, University of Cambridge, Cambridge, UK.; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Rodriguez-Meira A; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Bouriez-Jones T; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Macaulay IC; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; Earlham Institute, Norwich Research Park, NR4 7UZ, Norwich, UK., Jasztal M; Department of Haematology, University of Cambridge, Cambridge, UK.; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Zhu G; Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada.; CCOA Therapeutics Inc, Toronto, ON, M5B 1T8, Canada., Ni H; Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada.; CCOA Therapeutics Inc, Toronto, ON, M5B 1T8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, M5B 1W8, Canada., Robson MJ; Department of Biomedical Science, Charles E. Schmidt College of Medicine and Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, FL, 33458, USA.; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, 45267, USA., Blakely RD; Department of Biomedical Science, Charles E. Schmidt College of Medicine and Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, FL, 33458, USA., Mead AJ; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Nerlov C; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK., Ghevaert C; Department of Haematology, University of Cambridge, Cambridge, UK.; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Jacobsen SEW; Haematopoietic Stem Cell Biology Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK. sten.jacobsen@imm.ox.ac.uk.; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, OX3 9DS, Oxford, UK. sten.jacobsen@imm.ox.ac.uk.; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, SE-141 86, Stockholm, Sweden. sten.jacobsen@imm.ox.ac.uk.; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77, Stockholm, Sweden. sten.jacobsen@imm.ox.ac.uk.; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden. sten.jacobsen@imm.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2023 Sep 28; Vol. 14 (1), pp. 6062. Date of Electronic Publication: 2023 Sep 28.
Autor:
Bell AM; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.; School of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Utting C; Earlham Institute, Norwich NRU 7UZ, UK., Dickie AC; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Kucharczyk MW; The Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, UK.; Laboratory of Neurophysiology, Department of Biochemical Toxicology, Faculty of Pharmacy, Jagiellonian University Medical College, PL30-668 Krakow, Poland., Quillet R; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Gutierrez-Mecinas M; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Razlan ANB; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Cooper AH; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Lan Y; Earlham Institute, Norwich NRU 7UZ, UK., Hachisuka J; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Weir GA; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Bannister K; The Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, UK., Watanabe M; Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan., Kania A; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC, H2W 1R7, Canada., Hoon MA; Molecular Genetics Section, National Institute of Dental and Craniofacial Research/NIH, Bethesda, MD, USA., Macaulay IC; Earlham Institute, Norwich NRU 7UZ, UK., Denk F; The Wolfson Centre for Age-Related Diseases, King's College London, London WC2R 2LS, UK., Todd AJ; School of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 02. Date of Electronic Publication: 2023 Sep 02.