Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2

Autor: Michael Schertzer, Arturo Londoño-Vallejo, Aaron Mendez-Bermudez, Michelle Debatisse, Mylène Perderiset, Karine Jamet, Geneviève Almouzni, Jing Ye, Nicolas Nottet, Eric Gilson, Stephane Koundrioukoff, Marie Josèphe Giraud-Panis, Macarena Mowinckel, Liudmyla Lototska, Agurtzane Irizar, Olivier Croce, Serge Bauwens, Mare Paule Teulade-Fichou

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2018, 70 (3), pp.449-461.e5. ⟨10.1016/j.molcel.2018.03.036⟩
Molecular Cell, 2018, 70 (3), pp.449-461.e5. ⟨10.1016/j.molcel.2018.03.036⟩

Summary Hard-to-replicate regions of chromosomes (e.g., pericentromeres, centromeres, and telomeres) impede replication fork progression, eventually leading, in the event of replication stress, to chromosome fragility, aging, and cancer. Our knowledg

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https://hal.archives-ouvertes.fr/hal-02104993