Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients.

Autor: Macandog ADG; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Catozzi C; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Capone M; Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Nabinejad A; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Nanaware PP; Department of Radiation Oncology, Weill Cornell Medicine, New York, NY 10065, USA., Liu S; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA., Vinjamuri S; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612-7342, USA., Stunnenberg JA; Netherlands Cancer Institute (NKI)-AVL, North Holland, Amsterdam 1066 CX, the Netherlands., Galiè S; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Jodice MG; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Montani F; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Armanini F; Department of CIBIO, University of Trento, Trento, Povo 38123, Italy., Cassano E; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Madonna G; Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Mallardo D; Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Mazzi B; Ospedale San Raffaele IRCCS, Milan 20132, Italy., Pece S; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Tagliamonte M; Innovative Immunological Models, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Vanella V; Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Barberis M; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Ferrucci PF; Ospedale MultiMedica San Giuseppe, Milan 20132, Italy., Blank CU; Netherlands Cancer Institute (NKI)-AVL, North Holland, Amsterdam 1066 CX, the Netherlands., Bouvier M; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612-7342, USA., Andrews MC; Department of Medicine, School of Translational Medicine, Monash University, Melbourne, VIC 3004, Australia., Xu X; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-4238, USA., Santambrogio L; Department of Radiation Oncology, Weill Cornell Medicine, New York, NY 10065, USA., Segata N; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy; Department of CIBIO, University of Trento, Trento, Povo 38123, Italy., Buonaguro L; Innovative Immunological Models, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Cocorocchio E; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy., Ascierto PA; Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples 80131, Italy., Manzo T; Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin 10126, Italy., Nezi L; Department of Experimental Oncology, Istituto Europeo di Oncologia-IRCCS, Milan 20139, Italy. Electronic address: luigi.nezi@ieo.it.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 Nov 13; Vol. 32 (11), pp. 2004-2018.e9. Date of Electronic Publication: 2024 Oct 30.