Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.

Autor: Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Malagu K; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Haughan AF; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Stott AJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Esmieu W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Vater HD; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Webster SJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Van de Poël AJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clissold C; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Cosgrove B; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Sutton B; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Spencer JA; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Breccia P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Gancia E; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Bonomo S; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Ladduwahetty T; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lazari O; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Patel H; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Atton HC; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clifton S; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Mota DM; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Magnani D; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., O'Neill A; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Stebbeds M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Macabuag N; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Todd D; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Herva ME; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Mitchell P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Visser M; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Compte Sancerni S; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Grand Moursel L; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., da Silva M; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Kritikou E; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Heikkinen TT; Charles River, Microkatu 1, Kuopio 70210 Finland., Bolkvadze T; Charles River, Microkatu 1, Kuopio 70210 Finland., Fodale V; IRBM S.p.A., Pomezia, Roma 00071, Italy., Spadafora D; IRBM S.p.A., Pomezia, Roma 00071, Italy., Daldin M; IRBM S.p.A., Pomezia, Roma 00071, Italy., Bresciani A; IRBM S.p.A., Pomezia, Roma 00071, Italy., Mangette JE; Curia Global, Inc., Buffalo, New York 14203, United States., Doherty EM; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Monteagudo E; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Macdonald D; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Plotnikov NV; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Chambers M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., McAllister G; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Muňoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 13205-13246. Date of Electronic Publication: 2023 Sep 15.

Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.

Autor: Macabuag N; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Esmieu W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Breccia P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Jarvis R; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Blackaby W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lazari O; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Urbonas L; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Eznarriaga M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Williams R; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Strijbosch A; Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands., Van de Bospoort R; Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands., Matthews K; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clissold C; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Ladduwahetty T; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Vater H; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Heaphy P; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., Stafford DG; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., Wang HJ; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., Mangette JE; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., McAllister G; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Beaumont V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Vogt TF; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Wilkinson HA; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Doherty EM; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Sep 22; Vol. 65 (18), pp. 12445-12459. Date of Electronic Publication: 2022 Sep 13.

Trafficking of N-type voltage-gated calcium ion channels and their regulation by alternative splicing

Autor: Macabuag, N.

N-type voltage-gated calcium (CaV2.2) channels are expressed predominantly in the central and peripheral nervous systems and play a crucial role in neurotransmitter release. Expression of these channels at the plasma membrane and in the membrane of p

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746037

The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods.

Autor: Curcio, Antonio¹ (AUTHOR) antonio.curcio@unicz.it, Rocca, Roberta^1,2 (AUTHOR) alcaro@unicz.it, Alcaro, Stefano^1,2 (AUTHOR) artese@unicz.it, Artese, Anna^1,2 (AUTHOR)

Publikováno v: Pharmaceuticals (14248247). May2024, Vol. 17 Issue 5, p620. 48p.

Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues.

Autor: Pichlak, Marta¹ (AUTHOR), Sobierajski, Tomasz² (AUTHOR), Błażewska, Katarzyna M.² (AUTHOR) katarzyna.blazewska@p.lodz.pl, Gendaszewska-Darmach, Edyta¹ (AUTHOR) edyta.gendaszewska-darmach@p.lodz.pl

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-37. 37p.