The m6A demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification.

Autor: Wang Y; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., He S; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, China., Lan L; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Yu H; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, 511436, China.; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China., Zhao H; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Xie Y; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Zhong G; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Yuan L; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Li K; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Hu X; Department of Cardiology, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China., Macrae VE; Division of Functional Genetics, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Midlothian, UK., Fu X; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Chen G; Department of Cardiology, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China., Zhu D; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2024 Dec 10. Date of Electronic Publication: 2024 Dec 10.

Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells.

Autor: Yu H; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, China., Xie Y; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Lan L; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Ma S; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, China., Mok SWF; Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau, China., Wong IN; Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau, China., Wang Y; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Zhong G; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Yuan L; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Zhao H; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China., Hu X; Department of Cardiology, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China., Macrae VE; Functional Genetics and Development, The Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Midlothian, UK., He S; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong, 510515, China. Electronic address: hsp@smu.edu.cn., Chen G; Department of Cardiology, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: chenguojun@i.smu.edu.cn., Zhu D; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China. Electronic address: dongxing.zhu@gzhmu.edu.cn.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2024 Oct; Vol. 223, pp. 30-41. Date of Electronic Publication: 2024 Jul 23.

PFKFB3-driven vascular smooth muscle cell glycolysis promotes vascular calcification via the altered FoxO3 and lactate production.

Autor: Chen J; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Yu H; Department of Biochemistry and Molecular Biology, GMU-GIBH Joint School of Life Science, Guangzhou Medical University, Guangzhou, China., Tan X; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Mok SWF; Faculty of Medicine, Macau University of Science and Technology, Macau, China., Xie Y; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Wang Y; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Jiang X; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China., Macrae VE; Functional Genetics and Development, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Midlothian, UK., Lan L; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Fu X; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China., Zhu D; Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.; Department of Biochemistry and Molecular Biology, GMU-GIBH Joint School of Life Science, Guangzhou Medical University, Guangzhou, China.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 Oct; Vol. 37 (10), pp. e23182.

TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.

Autor: McNair AJ; The Roslin Institute, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, United Kingdom., Markby GR; The Roslin Institute, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, United Kingdom., Tang Q; The Roslin Institute, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, United Kingdom., MacRae VE; The Roslin Institute, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, United Kingdom., Corcoran BM; The Roslin Institute, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, United Kingdom.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easterbush Veterinary Centre, Roslin, United Kingdom.

Publikováno v: Frontiers in veterinary science [Front Vet Sci] 2023 Oct 16; Vol. 10, pp. 1202001. Date of Electronic Publication: 2023 Oct 16 (Print Publication: 2023).

TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.

Autor: Tang Q; The Roslin Institute, The University of Edinburgh, Edinburgh, UK.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Markby GR; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., MacNair AJ; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., Tang K; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., Tkacz M; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Parys M; The Roslin Institute, The University of Edinburgh, Edinburgh, UK.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Phadwal K; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., MacRae VE; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., Corcoran BM; The Roslin Institute, The University of Edinburgh, Edinburgh, UK.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK.

Publikováno v: Cell proliferation [Cell Prolif] 2023 Jun; Vol. 56 (6), pp. e13435. Date of Electronic Publication: 2023 Mar 04.