Zobrazeno 1 - 10
of 332
pro vyhledávání: '"MacRae F Linton"'
Autor:
QiPing Feng, Wei-Qi Wei, Cecilia P Chung, Rebecca T Levinson, Alexandra C Sundermann, Jonathan D Mosley, Lisa Bastarache, Jane F Ferguson, Nancy J Cox, Dan M Roden, Joshua C Denny, MacRae F Linton, Digna R Velez Edwards, C Michael Stein
Publikováno v:
PLoS Medicine, Vol 15, Iss 8, p e1002642 (2018)
BACKGROUND:Observations from statin clinical trials and from Mendelian randomization studies suggest that low low-density lipoprotein cholesterol (LDL-C) concentrations may be associated with increased risk of type 2 diabetes mellitus (T2DM). Despite
Externí odkaz:
https://doaj.org/article/bbb947f0461d4dfcbc0c34e59c03d106
Autor:
Caressa D Lietman, Amanda K Segedy, Bin Li, Sergio Fazio, James B Atkinson, MacRae F Linton, Pampee P Young
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184620 (2017)
Vascular smooth muscle cells (VSMCs) represent important modulators of plaque stability in advanced lesions. We previously reported that loss of small proline-rich repeat protein 3 (Sprr3), leads to VSMC apoptosis in a PI3K/Akt-dependent manner and a
Externí odkaz:
https://doaj.org/article/19d5758a5ab24459ba93596cceca88da
Autor:
Petra A Prins, Michael F Hill, David Airey, Sam Nwosu, Prudhvidhar R Perati, Hagai Tavori, Macrae F Linton, Valentina Kon, Sergio Fazio, Uchechukwu K Sampson
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84517 (2014)
Understanding variations in size and pattern of development of angiotensin II (Ang II)-induced abdominal aortic aneurysms (AAA) may inform translational research strategies. Thus, we sought insight into the temporal evolution of AAA in apolipoprotein
Externí odkaz:
https://doaj.org/article/b41d4ebf5d554501ab7376c01c53d0ee
Autor:
Lan Jiang, Srushti Gangireddy, Alyson L. Dickson, Yi Xin, Chao Yan, Vivian Kawai, Nancy J. Cox, MacRae F. Linton, Wei-Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100569- (2024)
Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic factors that influence HTG in studies focused predominantly on individuals of European ancestr
Externí odkaz:
https://doaj.org/article/da16de995003474fb80d5f0f18e3d4e6
Autor:
Ge Liu, Lan Jiang, V. Eric Kerchberger, Annette Oeser, Andrea Ihegword, Alyson L. Dickson, Laura L. Daniel, Christian Shaffer, MacRae F. Linton, Nancy Cox, Cecilia P. Chung, Wei‐Qi Wei, C. Michael Stein, QiPing Feng
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 489-501 (2023)
Abstract Sepsis accounts for one in three hospital deaths. Higher concentrations of high‐density lipoprotein cholesterol (HDL‐C) are associated with apparent protection from sepsis, suggesting a potential therapeutic role for HDL‐C or drugs, su
Externí odkaz:
https://doaj.org/article/f1784ad21d1243438fdafdbfcfef9f94
Autor:
Stacy Desine, Curtis L. Gabriel, Holly M. Smith, Olivia R. Antonetti, Chuan Wang, M. Wade Calcutt, Amanda C. Doran, Heidi J. Silver, Sangeeta Nair, James G. Terry, John Jeffrey Carr, MacRae F. Linton, Jonathan D. Brown, John R. Koethe, Jane F. Ferguson
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPlasma levels of the metabolite alpha-aminoadipic acid (2-AAA) have been associated with risk of type 2 diabetes (T2D) and atherosclerosis. However, little is known about the relationship of 2-AAA to other cardiometabolic risk markers in
Externí odkaz:
https://doaj.org/article/8f643703c27845e5a9c8cde550bcd571
Autor:
Michelle D. Kelsey, Hillary Mulder, Karen Chiswell, Zachary M. Lampron, Ester Nilles, Jacquelyn P. Kulinski, Parag H. Joshi, W. Schuyler Jones, Alanna M. Chamberlain, Thorsten M. Leucker, Wenke Hwang, M. Wesley Milks, Anuradha Paranjape, Jihad S. Obeid, MacRae F. Linton, Shia T. Kent, Eric D. Peterson, Emily C. O'Brien, Neha J. Pagidipati
Publikováno v:
American Journal of Preventive Cardiology, Vol 14, Iss , Pp 100478- (2023)
Objective: Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease, yet little is known about Lp(a) testing patterns in real-world practice. The objective of this analysis was to determine how Lp(a) testing is used i
Externí odkaz:
https://doaj.org/article/0a3f0dda35f94f75b4de745acee9e69b
Autor:
Marina Cuchel, Paul C. Lee, Lisa C. Hudgins, P. Barton Duell, Zahid Ahmad, Seth J. Baum, MacRae F. Linton, Sarah D. de Ferranti, Christie M. Ballantyne, John A. Larry, Linda C. Hemphill, Iris Kindt, Samuel S. Gidding, Seth S. Martin, Patrick M. Moriarty, Paul P. Thompson, James A. Underberg, John R. Guyton, Rolf L. Andersen, David J. Whellan, Irwin Benuck, John P. Kane, Kelly Myers, William Howard, David Staszak, Allison Jamison, Mary C. Card, Mafalda Bourbon, Joana R. Chora, Daniel J. Rader, Joshua W. Knowles, Katherine Wilemon, Mary P. McGowan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 9 (2023)
Background Homozygous familial hypercholesterolemia (HoFH) is a rare, treatment‐resistant disorder characterized by early‐onset atherosclerotic and aortic valvular cardiovascular disease if left untreated. Contemporary information on HoFH in the
Externí odkaz:
https://doaj.org/article/9dcee4a6f1ed4758895b21e17b75e550
Autor:
Mark Castleberry, Chase A. Raby, Anca Ifrim, Yasuhiro Shibata, Sachi Matsushita, Shinya Ugawa, Yutaka Miura, Atsushi Hori, Takashi Miida, MacRae F. Linton, Danielle L. Michell, Maki Tsujita, Kasey C. Vickers
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 2, Pp 100328- (2023)
HDL are dynamic transporters of diverse molecular cargo and play critical roles in lipid metabolism and inflammation. We have previously reported that HDL transport both host and nonhost small RNAs (sRNA) based on quantitative PCR and sRNA sequencing
Externí odkaz:
https://doaj.org/article/cb43c8cf5bf44960a92d7fff11b1433f
Autor:
Jiansheng Huang, Huan Tao, Patricia G. Yancey, Zoe Leuthner, Linda S. May-Zhang, Ju-Yang Jung, Youmin Zhang, Lei Ding, Venkataraman Amarnath, Dianxin Liu, Sheila Collins, Sean S. Davies, MacRae F. Linton
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101651- (2023)
Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cell
Externí odkaz:
https://doaj.org/article/9bfcb1b09a5a45c09eb332a263a9b04c