TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.

Autor: Tang Q; The Roslin Institute, The University of Edinburgh, Edinburgh, UK.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Markby GR; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., MacNair AJ; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., Tang K; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., Tkacz M; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Parys M; The Roslin Institute, The University of Edinburgh, Edinburgh, UK.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK., Phadwal K; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., MacRae VE; The Roslin Institute, The University of Edinburgh, Edinburgh, UK., Corcoran BM; The Roslin Institute, The University of Edinburgh, Edinburgh, UK.; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK.

Publikováno v: Cell proliferation [Cell Prolif] 2023 Jun; Vol. 56 (6), pp. e13435. Date of Electronic Publication: 2023 Mar 04.