Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson’s Disease Research and Therapeutic Development

Autor: Sarah F. McComish, Adina N. MacMahon Copas, Maeve A. Caldwell

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Parkinson’s disease (PD) is the second most common neurodegenerative disease and affects approximately 2–3% of the population over the age of 65. PD is characterised by the loss of dopaminergic neurons from the substantia nigra, leading to debili

Externí odkaz: https://doaj.org/article/7bdb586279e94252903ed3bf776f82f7

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CD4 ⁺ T cell-associated cytokines induce a chronic pro-inflammatory phenotype in induced pluripotent stem cell-derived midbrain astrocytes.

Autor: MacMahon Copas AN; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland., McComish SF; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland., Petrasca A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., McCormack R; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland., Ivers D; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland., Stricker A; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland., Fletcher JM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Caldwell MA; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland.

Publikováno v: Glia [Glia] 2024 Nov; Vol. 72 (11), pp. 2142-2154. Date of Electronic Publication: 2024 Jul 26.