A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

Autor: Hulin-Curtis, Sarah, Geary, James K., MacLachlan, Bruce J., Altmann, Danny M., Baillon, Laury, Cole, David K., Greenshields-Watson, Alex, Hesketh, Sophie J., Humphreys, Ian R., Jones, Ian M., Lauder, Sarah N., Mason, Georgina H., Smart, Kathryn, Scourfield, D. Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard J., Wall, Aaron, Rizkallah, Pierre J., Barclay, Wendy S., Gallimore, Awen, Godkin, Andrew

Publikováno v: In Cell Reports 25 June 2024 43(6)

Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity

Autor: Chen, Yuan, Mason, Georgina H., Scourfield, D. Oliver, Greenshields-Watson, Alexander, Haigh, Tracey A., Sewell, Andrew K., Long, Heather M., Gallimore, Awen M., Rizkallah, Pierre, MacLachlan, Bruce J., Godkin, Andrew

Publikováno v: In Cell Reports 29 August 2023 42(8)

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Molecular rules underpinning enhanced affinity binding of human T cell receptors engineered 2 for immunotherapy

Autor: Crean, Rory M, MacLachlan, Bruce J, Madura, Florian, Whalley, Thomas, Rizkallah, Pierre J, Holland, Christopher J, McMurran, Catriona, Harper, Stephen, Godkin, Andrew, Sewell, Andrew K, Pudney, Christopher R, Van Der Kamp, Marc W, Cole, David K

Publikováno v: Crean, R M, MacLachlan, B J, Madura, F, Whalley, T, Rizkallah, P J, Holland, C J, McMurran, C, Harper, S, Godkin, A, Sewell, A K, Pudney, C R, Van Der Kamp, M W & Cole, D K 2020, ' Molecular rules underpinning enhanced affinity binding of human T cell receptors engineered 2 for immunotherapy ', Molecular Therapy, vol. 18, pp. 443-456 . https://doi.org/10.1016/j.omto.2020.07.008

Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential to target virtually all cellular proteins, including cancer-specific epitopes, via the recognition of peptide-human leukocyte an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::6db2e9ce6c958e29e2f29c84277e1f00
https://hdl.handle.net/1983/3355d67e-4016-46f4-b0bc-458f48f82bdd

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