Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood

Autor: Kariotis, S, Jammeh, E, Swietlik, EM, Pickworth, JA, Rhodes, CJ, Otero, P, Wharton, J, Iremonger, J, Dunning, MJ, Pandya, D, Mascarenhas, TS, Errington, N, Thompson, AAR, Romanoski, CE, Rischard, F, Garcia, JGN, Yuan, JX-J, An, T-HS, Desai, AA, Coghlan, G, Lordan, J, Corris, PA, Howard, LS, Condliffe, R, Kiely, DG, Church, C, Pepke-Zaba, J, Toshner, M, Wort, S, Graf, S, Morrell, NW, Wilkins, MR, Lawrie, A, Wang, D, Bleda, M, Hadinnapola, C, Haimel, M, Auckland, K, Tilly, T, Martin, JM, Yates, K, Treacy, CM, Day, M, Greenhalgh, A, Shipley, D, Peacock, AJ, Irvine, V, Kennedy, F, Moledina, S, MacDonald, L, Tamvaki, E, Barnes, A, Cookson, V, Chentouf, L, Ali, S, Othman, S, Ranganathan, L, Gibbs, JSR, DaCosta, R, Pinguel, J, Dormand, N, Parker, A, Stokes, D, Ghedia, D, Tan, Y, Ngcozana, T, Wanjiku, I, Polwarth, G, Mackenzie Ross, RV, Suntharalingam, J, Grover, M, Kirby, A, Grove, A, White, K, Seatter, A, Creaser-Myers, A, Walker, S, Roney, S, Elliot, CA, Charalampopoulos, A, Sabroe, I, Hameed, A, Armstrong, I, Hamilton, N, Rothman, AMK, Swift, AJ, Wild, JM, Soubrier, F, Eyries, M, Humbert, M, Montani, D, Girerd, B, Scelsi, L, Ghio, S, Gall, H, Ghofrani, A, Bogaard, HJ, Noordegraaf, AV, Houweling, AC, Veld, AHI, Schotte, G

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
UK National PAH Cohort Study Consortium 2021, ' Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood ', Nature Communications, vol. 12, no. 1, 7104 . https://doi.org/10.1038/s41467-021-27326-0
Nature Communications, 12(1):7104. Nature Publishing Group UK
Nature Communications

Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms of pulmonary arterial hypertension, producing a heterogeneous population with varied treatment res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540a573941791c9c71a2fb0dff50f201
https://pubmed.ncbi.nlm.nih.gov/36433938

Diagnostic test accuracy of artificial intelligence analysis of cross-sectional imaging in pulmonary hypertension: a systematic literature review.

Autor: Hardacre CJ; Medical School, University of Bristol, Bristol, UK., Robertshaw JA; Medical School, University of Bristol, Bristol, UK., Barratt SL; Department of Respiratory Medicine, North Bristol NHS Trust, Bristol, UK., Adams HL; Brighton and Sussex Medical School, Brighton, UK., MacKenzie Ross RV; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Robinson GR; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Suntharalingam J; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK., Pauling JD; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK., Rodrigues JCL; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.; Department of Health, University of Bath, Bath, UK.

Publikováno v: The British journal of radiology [Br J Radiol] 2021 Dec; Vol. 94 (1128), pp. 20210332. Date of Electronic Publication: 2021 Sep 29.

Three challenges of partial anomalous pulmonary venous drainage associated with pulmonary hypertension.

Autor: MacKenzie Ross RV; Respiratory Department, Royal United Hospitals, Bath, UK.

Publikováno v: Respirology (Carlton, Vic.) [Respirology] 2020 Oct; Vol. 25 (10), pp. 1023-1024. Date of Electronic Publication: 2020 Jun 15.

Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.

Autor: Sofianopoulou E; MRC/BHF Cardiovascular Epidemiology Unit, Dept of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK.; Joint supervision., Kaptoge S; MRC/BHF Cardiovascular Epidemiology Unit, Dept of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK., Gräf S; Dept of Medicine, University of Cambridge, Cambridge, UK.; Dept of Haematology, University of Cambridge, Cambridge, UK.; NIHR BioResource - Rare Diseases, Cambridge, UK., Hadinnapola C; Dept of Medicine, University of Cambridge, Cambridge, UK., Treacy CM; Dept of Medicine, University of Cambridge, Cambridge, UK.; Pulmonary Vascular Diseases Unit, Royal Papworth Hospital, Cambridge, UK., Church C; Scottish Pulmonary Vascular Unit, Regional Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK.; BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Coghlan G; Dept of Cardiology, Royal Free Hospital, London, UK., Gibbs JSR; National Heart and Lung Institute, Imperial College London, London, UK.; National Pulmonary Hypertension Service, Hammersmith Hospital, London, UK., Haimel M; Dept of Medicine, University of Cambridge, Cambridge, UK.; Dept of Haematology, University of Cambridge, Cambridge, UK.; NIHR BioResource - Rare Diseases, Cambridge, UK., Howard LS; National Heart and Lung Institute, Imperial College London, London, UK.; National Pulmonary Hypertension Service, Hammersmith Hospital, London, UK., Johnson M; Scottish Pulmonary Vascular Unit, Regional Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK., Kiely DG; Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK., Lawrie A; Dept of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK., Lordan J; NIHR Biomedical Research Centre in Ageing, University of Newcastle, Newcastle, UK., MacKenzie Ross RV; National Pulmonary Hypertension Service, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Martin JM; Dept of Medicine, University of Cambridge, Cambridge, UK.; Dept of Haematology, University of Cambridge, Cambridge, UK.; NIHR BioResource - Rare Diseases, Cambridge, UK., Moledina S; National Paediatric Pulmonary Hypertension Service, Great Ormond Street Hospital, London, UK., Newnham M; Dept of Medicine, University of Cambridge, Cambridge, UK., Peacock AJ; Scottish Pulmonary Vascular Unit, Regional Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, UK., Price LC; National Heart and Lung Institute, Imperial College London, London, UK.; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK., Rhodes CJ; Centre for Pharmacology and Therapeutics, Dept of Medicine, Imperial College London, London, UK., Suntharalingam J; National Pulmonary Hypertension Service, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Swietlik EM; Dept of Medicine, University of Cambridge, Cambridge, UK.; Pulmonary Vascular Diseases Unit, Royal Papworth Hospital, Cambridge, UK., Toshner MR; Dept of Medicine, University of Cambridge, Cambridge, UK.; Pulmonary Vascular Diseases Unit, Royal Papworth Hospital, Cambridge, UK., Wharton J; Centre for Pharmacology and Therapeutics, Dept of Medicine, Imperial College London, London, UK., Wilkins MR; Centre for Pharmacology and Therapeutics, Dept of Medicine, Imperial College London, London, UK., Wort SJ; National Heart and Lung Institute, Imperial College London, London, UK.; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK., Pepke-Zaba J; Pulmonary Vascular Diseases Unit, Royal Papworth Hospital, Cambridge, UK., Condliffe R; Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK., Corris PA; NIHR Biomedical Research Centre in Ageing, University of Newcastle, Newcastle, UK., Di Angelantonio E; MRC/BHF Cardiovascular Epidemiology Unit, Dept of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Dept of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge, UK., Provencher S; Pulmonary Hypertension Research Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Laval University, Québec, QC, Canada., Morrell NW; Dept of Medicine, University of Cambridge, Cambridge, UK.; NIHR BioResource - Rare Diseases, Cambridge, UK.; Joint supervision.

Publikováno v: The European respiratory journal [Eur Respir J] 2019 May 30; Vol. 53 (5). Date of Electronic Publication: 2019 May 30 (Print Publication: 2019).

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Autor: Rhodes CJ; Department of Medicine, Imperial College London, London, UK., Batai K; Department of Surgery, University of Arizona, Tucson, AZ, USA., Bleda M; Department of Medicine, University of Cambridge, Cambridge, UK., Haimel M; Department of Medicine, University of Cambridge, Cambridge, UK., Southgate L; Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK., Germain M; Sorbonne Universités, UPMC, INSERM, Paris, France., Pauciulo MW; Human Genetics, Cincinnati, OH, USA., Hadinnapola C; Department of Medicine, University of Cambridge, Cambridge, UK., Aman J; Department of Medicine, Imperial College London, London, UK., Girerd B; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Arora A; Department of Surgery, University of Arizona, Tucson, AZ, USA., Knight J; Data Science Institute, Lancaster University, Lancaster, UK., Hanscombe KB; Genetics and Molecular Medicine, King's College London, London, UK., Karnes JH; Pharmacy Practice and Science, University of Arizona, Tucson, AZ, USA., Kaakinen M; Department of Medicine, Imperial College London, London, UK., Gall H; University of Giessen and Marburg Lung Center, Giessen, Germany., Ulrich A; Department of Medicine, Imperial College London, London, UK., Harbaum L; Department of Medicine, Imperial College London, London, UK., Cebola I; Department of Medicine, Imperial College London, London, UK., Ferrer J; Department of Medicine, Imperial College London, London, UK., Lutz K; Human Genetics, Cincinnati, OH, USA., Swietlik EM; Department of Medicine, University of Cambridge, Cambridge, UK., Ahmad F; University of Iowa, Iowa City, IA, USA., Amouyel P; University of Lille, Lille, France., Archer SL; Queen's University, Kingston, ON, Canada., Argula R; Medical University of South Carolina, Charleston, SC, USA., Austin ED; Vanderbilt University, Nashville, TN, USA., Badesch D; University of Colorado Denver, Denver, CO, USA., Bakshi S; Baylor Research Institute, Plano, TX, USA., Barnett C; Medstar Health, Washington, DC, USA., Benza R; Allegheny-Singer Research Institute, Pittsburgh, PA, USA., Bhatt N; Ohio State University, Columbus, OH, USA., Bogaard HJ; VU University Medical Center, Amsterdam, Netherlands., Burger CD; Mayo Clinic Florida, Jacksonville, FL, USA., Chakinala M; Washington University, St Louis, MO, USA., Church C; Golden Jubilee National Hospital, Glasgow, UK., Coghlan JG; Royal Free Hospital, London, UK., Condliffe R; Royal Hallamshire Hospital, Sheffield, UK., Corris PA; University of Newcastle, Newcastle, UK., Danesino C; University of Pavia, Pavia, Italy., Debette S; University of Bordeaux, Bordeaux, France., Elliott CG; Intermountain Medical Center, Murray, UT, USA., Elwing J; University of Cincinnati, Cincinnati OH, USA., Eyries M; Sorbonne Universités, UPMC, INSERM, Paris, France., Fortin T; Duke University Medical Center, Durham, NC, USA; University of Kiel, Kiel, Germany., Franke A; University of Kiel, Kiel, Germany., Frantz RP; Mayo Clinic, Rochester, MN, USA., Frost A; Houston Methodist Research Institute, Houston, TX, USA., Garcia JGN; Department of Medicine, University of Arizona, Tucson, AZ, USA., Ghio S; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Ghofrani HA; University of Giessen and Marburg Lung Center, Giessen, Germany., Gibbs JSR; National Heart and Lung Institute, Imperial College London, London, UK., Harley J; CAGE, Cincinnati, OH, USA., He H; Human Genetics, Cincinnati, OH, USA., Hill NS; Tufts-New England Medical Center, Boston, MA, USA., Hirsch R; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; University of Cincinnati, Cincinnati OH, USA., Houweling AC; VU University Medical Center, Amsterdam, Netherlands., Howard LS; National Heart and Lung Institute, Imperial College London, London, UK., Ivy D; Health Sciences Center, University of Colorado, Aurora, CO, USA., Kiely DG; Royal Hallamshire Hospital, Sheffield, UK., Klinger J; Rhode Island Hospital, Providence, RI, USA., Kovacs G; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Lahm T; Indiana University, Indianapolis, IN, USA., Laudes M; University of Kiel, Kiel, Germany., Machado RD; University of Lincoln, Lincoln, UK., MacKenzie Ross RV; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Marsolo K; Biomedical Informatics, Cincinnati, OH, USA., Martin LJ; Human Genetics, Cincinnati, OH, USA., Moledina S; Great Ormond Street Hospital, London, UK., Montani D; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Nathan SD; Inova Heart and Vascular Institute, Falls Church, VA, USA., Newnham M; Department of Medicine, University of Cambridge, Cambridge, UK; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Olschewski A; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Olschewski H; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Oudiz RJ; Harbor-UCLA Medical Center, Torrance, CA, USA., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, UK., Peacock AJ; Golden Jubilee National Hospital, Glasgow, UK., Pepke-Zaba J; Papworth Hospital, Papworth, UK., Rehman Z; East Carolina University, Greenville, NC, USA., Robbins I; Vanderbilt University School of Medicine, Nashville, TN, USA., Roden DM; Vanderbilt University School of Medicine, Nashville, TN, USA., Rosenzweig EB; Columbia University, New York, NY, USA., Saydain G; Wayne State University, Detroit, MI, USA., Scelsi L; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Schilz R; University Hospital of Cleveland, Cleveland, OH, USA., Seeger W; University of Giessen and Marburg Lung Center, Giessen, Germany., Shaffer CM; Vanderbilt University School of Medicine, Nashville, TN, USA., Simms RW; Boston University School of Medicine, Boston, MA, USA., Simon M; University of Pittsburgh, Pittsburgh, PA, USA., Sitbon O; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Suntharalingam J; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Tang H; Department of Medicine, University of Arizona, Tucson, AZ, USA., Tchourbanov AY; Ambry Genetics, Aliso Viejo, CA, USA., Thenappan T; University of Minnesota, Minneapolis, MN, USA., Torres F; University of Texas Southwestern Medical Center, Dallas, TX, USA., Toshner MR; Department of Medicine, University of Cambridge, Cambridge, UK., Treacy CM; Department of Medicine, University of Cambridge, Cambridge, UK., Vonk Noordegraaf A; VU University Medical Center, Amsterdam, Netherlands., Waisfisz Q; VU University Medical Center, Amsterdam, Netherlands., Walsworth AK; Human Genetics, Cincinnati, OH, USA., Walter RE; Louisiana State University Health, Shreveport, LA, USA., Wharton J; Department of Medicine, Imperial College London, London, UK., White RJ; University of Rochester Medical Center, Rochester, NY, USA., Wilt J; Spectrum Health Hospitals, Grand Rapids, MI, USA., Wort SJ; National Heart and Lung Institute, Imperial College London, London, UK., Yung D; Seattle Children's Hospital, Seattle, WA, USA., Lawrie A; University of Sheffield, Sheffield, UK., Humbert M; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Soubrier F; Sorbonne Universités, UPMC, INSERM, Paris, France., Trégouët DA; Sorbonne Universités, UPMC, INSERM, Paris, France., Prokopenko I; Department of Medicine, Imperial College London, London, UK., Kittles R; City of Hope, Duarte, CA, USA., Gräf S; Department of Medicine, University of Cambridge, Cambridge, UK., Nichols WC; Human Genetics, Cincinnati, OH, USA., Trembath RC; Genetics and Molecular Medicine, King's College London, London, UK., Desai AA; Indiana University, Indianapolis, IN, USA. Electronic address: ankdesai@iu.edu., Morrell NW; Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: nwm23@cam.ac.uk., Wilkins MR; Department of Medicine, Imperial College London, London, UK. Electronic address: m.wilkins@imperial.ac.uk.

Publikováno v: The Lancet. Respiratory medicine [Lancet Respir Med] 2019 Mar; Vol. 7 (3), pp. 227-238. Date of Electronic Publication: 2018 Dec 05.