Zobrazeno 1 - 10
of 12
pro vyhledávání: '"MacKenzie Fuller"'
Autor:
Debashis Sahoo, Lee Swanson, Ibrahim M. Sayed, Gajanan D. Katkar, Stella-Rita Ibeawuchi, Yash Mittal, Rama F. Pranadinata, Courtney Tindle, Mackenzie Fuller, Dominik L. Stec, John T. Chang, William J. Sandborn, Soumita Das, Pradipta Ghosh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Traditional drug discovery process use differential, Bayesian and other network based approaches. We developed a Boolean approach for building disease maps and prioritizing pre-clinical models to discover a first-in-class therapy to restore and prote
Externí odkaz:
https://doaj.org/article/d3b3157a040445e7931fa319037c2287
Autor:
Malina A. Bakowski, Nathan Beutler, Karen C. Wolff, Melanie G. Kirkpatrick, Emily Chen, Tu-Trinh H. Nguyen, Laura Riva, Namir Shaabani, Mara Parren, James Ricketts, Anil K. Gupta, Kastin Pan, Peiting Kuo, MacKenzie Fuller, Elijah Garcia, John R. Teijaro, Linlin Yang, Debashis Sahoo, Victor Chi, Edward Huang, Natalia Vargas, Amanda J. Roberts, Soumita Das, Pradipta Ghosh, Ashley K. Woods, Sean B. Joseph, Mitchell V. Hull, Peter G. Schultz, Dennis R. Burton, Arnab K. Chatterjee, Case W. McNamara, Thomas F. Rogers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.
Externí odkaz:
https://doaj.org/article/b79629899ac84da0ab6e053c69619b49
Autor:
Jingting Li, Xiaojun Xu, Manisha Tiwari, Yifang Chen, Mackenzie Fuller, Varun Bansal, Pablo Tamayo, Soumita Das, Pradipta Ghosh, George L. Sen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The role of RNA polymerase II (Pol II) recruitment during adult stem cell differentiation is well understood, but not that of Pol II elongation. Here, the authors show that 30% of epidermal stem cell differentiation genes depend on SPT6 and PAF1 for
Externí odkaz:
https://doaj.org/article/43fb4cb1baf649f582d46af97ad377ec
Autor:
Courtney Tindle, MacKenzie Fuller, Ayden Fonseca, Sahar Taheri, Stella-Rita Ibeawuchi, Nathan Beutler, Gajanan Dattatray Katkar, Amanraj Claire, Vanessa Castillo, Moises Hernandez, Hana Russo, Jason Duran, Laura E Crotty Alexander, Ann Tipps, Grace Lin, Patricia A Thistlethwaite, Ranajoy Chattopadhyay, Thomas F Rogers, Debashis Sahoo, Pradipta Ghosh, Soumita Das
Publikováno v:
eLife, Vol 10 (2021)
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. Methods: We present a scalable, propagable, personalized, cost-effective
Externí odkaz:
https://doaj.org/article/a2f6ea2e6df643eab8feb143e8860634
Autor:
Debashis Sahoo, Gajanan D. Katkar, Soni Khandelwal, Mahdi Behroozikhah, Amanraj Claire, Vanessa Castillo, Courtney Tindle, MacKenzie Fuller, Sahar Taheri, Thomas F. Rogers, Nathan Beutler, Sydney I. Ramirez, Stephen A. Rawlings, Victor Pretorius, Davey M. Smith, Dennis R. Burton, Laura E. Crotty Alexander, Jason Duran, Shane Crotty, Jennifer M. Dan, Soumita Das, Pradipta Ghosh
Publikováno v:
EBioMedicine, Vol 68, Iss , Pp 103390- (2021)
Background: Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the “cytokine storm” that has been implicated in fatal COVID-1
Externí odkaz:
https://doaj.org/article/9fb0f37039614a41b6bb64dc3f67cb9a
Autor:
Soumita Das, Courtney Tindle, Ayden G. Fonseca, Vanessa Castillo, Pradipta Ghosh, Ranajoy Chattopadhyay, MacKenzie Fuller, Gajanan D. Katkar, Jason M. Duran, Patricia A. Thistlethwaite, Ann Tipps, Grace Y. Lin, Laura E. Crotty Alexander, Moises Hernandez, Stella-Rita Ibeawuchi, Nathan Beutler, Sahar Taheri, Amanraj Claire, Hana Russo, Debashis Sahoo, Thomas F. Rogers
Publikováno v:
eLife
eLife, Vol 10 (2021)
bioRxiv
eLife, Vol 10 (2021)
bioRxiv
Author(s): Tindle, Courtney; Fuller, MacKenzie; Fonseca, Ayden; Taheri, Sahar; Ibeawuchi, Stella-Rita; Beutler, Nathan; Katkar, Gajanan Dattatray; Claire, Amanraj; Castillo, Vanessa; Hernandez, Moises; Russo, Hana; Duran, Jason; Crotty Alexander, Lau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd08076fa5aaf05cc73127cc206cd1f
https://escholarship.org/uc/item/0503r9x1
https://escholarship.org/uc/item/0503r9x1
Autor:
Mitchell V. Hull, Amanda J. Roberts, Anil Gupta, Laura Riva, Ashley K. Woods, Karen C. Wolff, Dennis R. Burton, Emily I. Chen, Peiting Kuo, James Ricketts, Melanie G. Kirkpatrick, Malina A. Bakowski, MacKenzie Fuller, John R. Teijaro, Sean B. Joseph, Soumita Das, Namir Shaabani, Case W. McNamara, Linlin Yang, Natalia Vargas, Elijah Garcia, Debashis Sahoo, Thomas F. Rogers, Nathan Beutler, Mara Parren, Edward Huang, Pradipta Ghosh, Tu-Trinh Nguyen, Arnab K. Chatterjee, Kastin Pan, Peter G. Schultz, Victor Chi
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
The ongoing pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), necessitates strategies to identify prophylactic and therapeutic drug candidates for rapid clinical deployment. Here, we describe a screening pipel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f281105d6c6d795c68ba008096e5247
https://escholarship.org/uc/item/77f9r1t7
https://escholarship.org/uc/item/77f9r1t7
Autor:
Vanessa Castillo, Pradipta Ghosh, Sahar Taheri, Nathan Beutler, MacKenzie Fuller, Amanraj Claire, Ann Tipps, Jason M. Duran, Grace Y. Lin, Ranajoy Chattopadhyay, Patricia A. Thistlethwaite, Debashis Sahoo, Thomas F. Rogers, Gajanan D. Katkar, Ayden G. Fonseca, Soumita Das, Hana Russo, Courtney Tindle, Stella-Rita C Ibeawuchi, Moises Hernandez, Laura E. Crotty Alexander
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc67e30a59b56c1bfe0aaf17080920eb
https://doi.org/10.7554/elife.66417.sa2
https://doi.org/10.7554/elife.66417.sa2
Autor:
Courtney Tindle, Daniella T. Vo, Mahitha Shree Anandachar, Pradipta Ghosh, Soumita Das, MacKenzie Fuller, Debashis Sahoo
SUMMARYTransient depletion of the transcription elongation factor SPT6 in the keratinocyte has been recently shown to inhibit epidermal differentiation and stratification; instead, they transdifferentiate into a gut-like lineage. We show here that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc20283ae0f08a303dadde80ffe3fa5
https://doi.org/10.1101/2021.05.06.442930
https://doi.org/10.1101/2021.05.06.442930
Autor:
Gajanan Dattatray Katkar, Courtney Tindle, Ayden Fonseca, Sahar Taheri, Jasper Lee, Ibrahim M. Sayed, Stella-Rita Ibeawuchi, Pranadinata Rama, Mackenzie Fuller, Dominik Stec, Mahitha Shree Anandachar, Vanae Goheen-Holland, Jason Ear, Brigid Boland, William Sandborn, Debashis Sahoo, Soumita Das, Pradipta Ghosh
Publikováno v:
The Journal of Immunology. 208:115.22-115.22
Adult stem cells from various organs can be propagated as epithelial organoids that not only retain their tissue identity, but also their genetic and epigenetic disease-driving traits. We report the establishment of Crohn’s Disease (CD) patient-der