High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection

Autor: Monaghan,Tanya M, Negm,Ola H, MacKenzie,Brendon, Hamed,Mohamed R, Shone,Clifford C, Humphreys,David P, Acharya,K Ravi, Wilcox,Mark H

Tanya M Monaghan,1 Ola H Negm,2,3 Brendon MacKenzie,4 Mohamed R Hamed,2,3 Clifford C Shone,5 David P Humphreys,4 K Ravi Acharya,6 Mark H Wilcox7 1Nottingham Digestive Diseases Centre, NIHR Nottingham Digestive Diseases Biomedical Research Unit, Schoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::15df45a7ea29a49d778c50d0662ca89b

Sa1777 - High Prevalence of Subclass-Specific Binding and Neutralising Antibodies Against Clostridium Difficile Toxins in Adult Cystic Fibrosis Sera: Possible Mode of Protection Against Symptomatic Clostridium Difficile Infection

Autor: Monaghan, Tanya, Negm, Ola, MacKenzie, Brendon, Hamed, Mohamed, Shone, Clifford, Humphreys, David P., Ravi Acharya, K., Wilcox, Mark

Publikováno v: In Gastroenterology April 2017 152(5) Supplement 1:S344-S344

A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficileTcdA and TcdB with High Levels of In VitroPotency Shows In VivoProtection in a Hamster Infection Model

Autor: Davies, Nicola L., Compson, Joanne E., MacKenzie, Brendon, O'Dowd, Victoria L., Oxbrow, Amanda K. F., Heads, James T., Turner, Alison, Sarkar, Kaushik, Dugdale, Sarah L., Jairaj, Mark, Christodoulou, Louis, Knight, David E. O., Cross, Amanda S., Hervé, Karine J. M., Tyson, Kerry L., Hailu, Hanna, Doyle, Carl B., Ellis, Mark, Kriek, Marco, Cox, Matthew, Page, Matthew J. T., Moore, Adrian R., Lightwood, Daniel J., Humphreys, David P.

Publikováno v: Clinical and Vaccine Immunology (formerly CDLI); January 2013, Vol. 20 Issue: 3 p377-390, 14p

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Autor: Monaghan TM; Nottingham Digestive Diseases Centre, NIHR Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, University of Nottingham, Nottingham., Negm OH; Breast Surgery Group, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., MacKenzie B; Antibody Biology, UCB-New Medicines, UCB Celltech, Slough, UK., Hamed MR; Breast Surgery Group, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.; Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Shone CC; Toxins Group, National Infection Service, Public Health England, Salisbury, UK., Humphreys DP; Antibody Biology, UCB-New Medicines, UCB Celltech, Slough, UK., Acharya KR; Department of Biology and Biochemistry, University of Bath, Bath, UK., Wilcox MH; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.

Publikováno v: Clinical and experimental gastroenterology [Clin Exp Gastroenterol] 2017 Jul 19; Vol. 10, pp. 169-175. Date of Electronic Publication: 2017 Jul 19 (Print Publication: 2017).