Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy.

Autor: Shen C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada; School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China. Electronic address: shenchuanbin@ouc.edu.cn., Mackeigan DT; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Shoara AA; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Bhoria P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada., Zhu G; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada., Karakas D; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada., Ma W; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada., Chen ZY; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada., Xu R; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada., Slavkovic S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Zhang D; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada., Prifti V; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada., Liu Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada., Cerenzia EG; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Chen P; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Neves MAD; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Li H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Key Laboratory of Gene Therapy for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Xue F; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Key Laboratory of Gene Therapy for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Yang R; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Key Laboratory of Gene Therapy for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Liu J; Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Lai R; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China., Li R; Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine Atlanta, Atlanta, Georgia, Georgia, USA., Ni H; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, Li Ka Shing Knowledge Institute (LKSKI)-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada; CCOA Therapeutics Inc, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: Heyu.Ni@unityhealth.to.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Nov; Vol. 22 (11), pp. 3249-3265. Date of Electronic Publication: 2024 Aug 13.

Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site.

Autor: Neves MAD; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Ni TT; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Mackeigan DT; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Shoara AA; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Chemistry and Centre for Research on Biomolecular Interactions, York University, Toronto, Ontario, Canada., Lei X; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Slavkovic S; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Yu SY; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Stratton TW; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Gallant RC; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Zhang D; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Xu XR; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Fernandes C; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Zhu G; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada., Hu X; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Chazot N; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada., Donaldson LW; Department of Chemistry and Centre for Research on Biomolecular Interactions, York University, Toronto, Ontario, Canada., Johnson PE; Department of Chemistry and Centre for Research on Biomolecular Interactions, York University, Toronto, Ontario, Canada., Connelly K; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Rand M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Division of Hematology, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Wang Y; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada.; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.; Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada., Ni H; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Toronto Platelet Immunobiology Group, University of Toronto, Toronto, Ontario, Canada.; Canadian Blood Services Centre for Innovation, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2024 May 17; Vol. 8 (4), pp. 102443. Date of Electronic Publication: 2024 May 17 (Print Publication: 2024).

SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19.

Autor: Ma X; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Liang J; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Zhu G; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Bhoria P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Shoara AA; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., MacKeigan DT; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Khoury CJ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Slavkovic S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada., Lin L; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Karakas D; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Chen Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada., Prifti V; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Liu Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Shen C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Li Y; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China., Zhang C; CCOA Therapeutics Inc., Toronto, ON, Canada.; Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China., Dou J; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Rousseau Z; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Zhang J; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Ni T; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Lei X; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Chen P; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada., Wu X; Advanced Pharmaceutics & Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Shaykhalishahi H; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada., Mubareka S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Medical Microbiology and Infectious Disease, Sunnybrook Health Science Centre, Toronto, ON, Canada., Connelly KA; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada., Zhang H; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.; Department of Medical Microbiology and Infectious Disease, Sunnybrook Health Science Centre, Toronto, ON, Canada.; Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada., Rotstein O; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Department of Surgery, University of Toronto, Toronto, ON, Canada., Ni H; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; CCOA Therapeutics Inc., Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.

Publikováno v: Research (Washington, D.C.) [Research (Wash D C)] 2023 Apr 24; Vol. 6, pp. 0124. Date of Electronic Publication: 2023 Apr 24 (Print Publication: 2023).

Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude.

Autor: Li M; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; College of Agriculture and Life Sciences, Kunming University, Kunming, China., Tang X; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, China., Liao Z; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Shen C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital and Toronto Platelet Immunobiology Group, Toronto, ON, Canada., Cheng R; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Fang M; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Wang G; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, China., Li Y; Department of Clinical Laboratory, Yunnan Key Laboratory of Laboratory Medicine, Yunnan Innovation Team of Clinical Laboratory and Diagnosis, the First Affiliated Hospital of Kunming Medical University, Kunming, China., Tang S; Department of Clinical Laboratory, the People's Hospital of Diqing Tibetan Autonomous Prefecture, Shangri-La, China., Xie L; Department of Clinical Laboratory, the Second Affiliated Hospital of Guangxi Medical University, Nanning, China., Zhang Z; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, China., Kamau PM; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Mwangi J; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Lu Q; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, China., Li Y; Department of Cardiovascular Surgery, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, China., Wang Y; Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming, China., MacKeigan DT; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital and Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Cerenzia EG; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital and Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Ni H; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital and Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Lai R; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology-The Chinese University of Hong Kong Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, China.

Publikováno v: Blood [Blood] 2022 Nov 10; Vol. 140 (19), pp. 2063-2075.

Control of data variations in intravital microscopy thrombosis models.

Autor: Lei X; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada., MacKeigan DT; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Ni H; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.; Toronto Platelet Immunobiology Group, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Canadian Blood Services Centre for Innovation, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Nov; Vol. 18 (11), pp. 2823-2825.