Antibacterial Agents that Inhibit Two-Component Signal Transduction Systems

Autor: Barrett, J. F., Goldschmidt, R. M., Lawrence, L. E., Foleno, B., Chen, R., Demers, J. P., Johnson, S., Kanojia, R., Fernandez, J., Bernstein, J., Licata, L., Donetz, A., Huang, S., Hlasta, D. J., Macielag, M. J., Ohemeng, K., Frechette, R., Frosco, M. B., Klaubert, D. H., Whiteley, J. M., Wang, L., Hoch, J. A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1998 Apr . 95(9), 5317-5322.

Externí odkaz: https://www.jstor.org/stable/44711

Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists.

Autor: Zhu B; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Zhang X; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Guo L; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Rankin M; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Bakaj I; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Ho G; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Lee SP; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Norquay L; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States., Macielag M; Discovery Chemistry and Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Dec 07; Vol. 13 (1), pp. 111-117. Date of Electronic Publication: 2021 Dec 07 (Print Publication: 2022).

Erratum to "Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists" [Bioorg. Med. Chem. Lett. 47 (2021) 128172].

Autor: Zhang X; Discovery Sciences, Discovery Chemistry, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States. Electronic address: xzhang@proteovant.com., Zhu B; Discovery Sciences, Discovery Chemistry, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Guo L; Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Bakaj I; Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Rankin M; Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Ho G; Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Kauffman J; Discovery Sciences, Lead Discovery, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Lee SP; Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Norquay L; Cardiovascular and Metabolism Research, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States., Macielag M; Discovery Sciences, Discovery Chemistry, Janssen Research & Development, LLC, 1400 McKean Road, Box 776, Spring House, PA 19477, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Sep 01; Vol. 47, pp. 128232. Date of Electronic Publication: 2021 Jul 01.

Occurrence and characterization of plasmid-encoded qnr genes in quinolone-resistant bacteria across diverse aquatic environments in southern Ontario.

Autor: Yusuf, Farhan¹ (AUTHOR), Ahmed, Saher M.² (AUTHOR), Dy, Danica³ (AUTHOR), Baney, Katherine⁴ (AUTHOR), Waseem, Hassan¹ (AUTHOR), Gilbride, Kimberley A.^1,2 (AUTHOR) gilbride@torontomu.ca

Publikováno v: Canadian Journal of Microbiology. 2024, Vol. 70 Issue 11, p492-506. 15p.

Novel Phenoxyalkanoic Acid Derivatives as Free Fatty Acid Receptor 4 Agonists for Treating Type 2 Diabetes Mellitus.

Autor: Li, Xu¹ (AUTHOR) lx221024@126.com, Zhang, Xinmeng¹ (AUTHOR) 18241016451@163.com, Xie, Xueyuan¹ (AUTHOR) 18863356238@163.com, Dong, Taimin¹ (AUTHOR) 17616455575@163.com, Lv, Chengxu¹ (AUTHOR) 17861811130@163.com, Guan, Ranran¹ (AUTHOR) grr19819342198@163.com, Zhang, Wenyue¹ (AUTHOR) z19806100327@163.com, Ji, Guoxia² (AUTHOR) jiguoxia@lcu.edu.cn, Chen, Fanghui¹ (AUTHOR) chenfanghui@lcu.edu.cn, Wang, Shiben¹ (AUTHOR) wangshiben@lcu.edu.cn, Wang, Xuekun¹ (AUTHOR) wangshiben@lcu.edu.cn

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11476. 17p.