Výsledky vyhledávání - "Mac E. Hadley"

Design, synthesis, and biological activities of a potent and selective α-melanotropin antagonist

Autor: Tomi K. Sawyer, Fahad Al-Obeidi, Mac E. Hadley, Victor J. Hruby, Ana Maria de L. Castrucci

Publikováno v: International Journal of Peptide and Protein Research. 35:228-234

Based on structure-activity relationships of the potent alpha-MSH agonist, Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10-NH2, several analogs of the general formula Ac-Nle4-Asp5-Waa6-Xaa7-Yaa8-Zaa9-Lys10+ ++-NH2 were synthesized and tested on frog and liz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38ba31c4297270ee5955683f82deae4
https://doi.org/10.1111/j.1399-3011.1990.tb00942.x

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Comparative biological activities of potent active-site analogues of α-melanotropin. Effect of tyrosine substitution at position-4

Autor: Victor J. Hruby, Brian C. Wilkes, Mac E. Hadley, Tomi K. Sawyer

Publikováno v: International Journal of Peptide and Protein Research. 23:621-629

We have prepared several α-melanotropin (α-MSH) analogues with tyrosine substituted for methionine at the 4-position and determined their melanotropic activities on the frog (Rana pipiens), lizard (Anolis carolinensis) and S-91 (Cloudman) mouse mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f36cb8e58053895eba1771d7745446
https://doi.org/10.1111/j.1399-3011.1984.tb03134.x

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SYNTHESIS OF α- AND β-MELANOCYTE STIMULATING HORMONES*

Autor: Mac E. Hadley, Victor J. Hruby, Christopher B. Heward, Young C. S. Yang

Publikováno v: International Journal of Peptide and Protein Research. 15:130-138

The solid phase synthesis of alpha-melanocyte stimulating hormone (alpha-MSH) using the benzhydrylamine resin and a number of recently described side chain protecting groups is given. The carboxamide terminal peptide was obtained directly by treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1233e227774d833bc422982521bec2a6
https://doi.org/10.1111/j.1399-3011.1980.tb02559.x

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Comparative biological activities of potent analogues of α-melanotropin

Autor: Victor J. Hruby, Mac E. Hadley, Wayne L. Cody, Brian C. Wilkes, Ana Marie de L. Castrucci

Publikováno v: International Journal of Peptide and Protein Research. 27:685-694

Several alpha-melanotropin (alpha-MSH) analogues with para substituted aromatic and nonaromatic amino acids in the 7-position of the hormone were prepared and their melanotropic activities determined in the frog (Rana pipiens) and lizard (Anolis caro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87cbd2150a68ec16cdcfff4a54d082ab
https://doi.org/10.1111/j.1399-3011.1986.tb01066.x

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Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization

Autor: Mac E. Hadley, Robert T. Dorr

Publikováno v: Peptides. 27:921-930

The melanocortins (MCs) are a family of multifunctional peptidergic hormones. Several superpotent, prolonged acting, enzymatically resistant, MC analogs have been designed and synthesized to help clarify the nature and role of MCs and their receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b86eaa97d8e3495447416bcaa616cb
https://doi.org/10.1016/j.peptides.2005.01.029

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