The effect of TG2-inhibitory monoclonal antibody zampilimab on tissue fibrosis in human in vitro and primate in vivo models of chronic kidney disease.

Autor: Linghong Huang, Helene Bon, Mabrouka Maamra, Toby Holmes, John Atkinson, Katharine Cain, Jeff Kennedy, Catherine Kettleborough, David Matthews, Breda Twomey, Jia Ni, Zhizhan Song, Philip F Watson, Timothy S Johnson

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0298864 (2024)

Fibrotic remodeling is the primary driver of functional loss in chronic kidney disease, with no specific anti-fibrotic agent available for clinical use. Transglutaminase 2 (TG2), a wound response enzyme that irreversibly crosslinks extracellular matr

Externí odkaz: https://doaj.org/article/7737e1a42d454e9d95b052f6ac871f2f

Transglutaminase 2: Development of therapeutic antibodies reveals four inhibitory epitopes and confirms extracellular function in fibrotic remodelling

Autor: Mabrouka Maamra, Osama Mehdi Benayad, David Matthews, Catherine Kettleborough, John Atkinson, Katharine Cain, Helene Bon, Helen Brand, Michael Parkinson, Philip F. Watson, Timothy S. Johnson

Publikováno v: British Journal of Pharmacology. 179:2697-2712

Transglutaminase type 2 (TG2) catalyses formation of ε-(γ-glutamyl)-lysine bonds between proteins, including those of the extracellular matrix (ECM). Elevated extracellular TG2 leads to accelerated ECM deposition and reduced clearance that underlie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ffde6501784ba28bc99a3b97d7f626
https://doi.org/10.1111/bph.15774

The effect of TG2-inhibitory monoclonal antibody zampilimab on tissue fibrosis in human in vitro and primate in vivo models of chronic kidney disease.

Autor: Huang, Linghong^1,2 (AUTHOR), Bon, Helene¹ (AUTHOR), Maamra, Mabrouka³ (AUTHOR), Holmes, Toby³ (AUTHOR), Atkinson, John¹ (AUTHOR), Cain, Katharine^1,2 (AUTHOR), Kennedy, Jeff¹ (AUTHOR), Kettleborough, Catherine⁴ (AUTHOR), Matthews, David^4,5 (AUTHOR), Twomey, Breda¹ (AUTHOR), Ni, Jia⁶ (AUTHOR), Song, Zhizhan⁶ (AUTHOR), Watson, Philip F.³ (AUTHOR), Johnson, Timothy S.^1,2,3 (AUTHOR) t.johnson@sheffield.ac.uk

Publikováno v: PLoS ONE. 5/16/2024, Vol. 19 Issue 5, p1-27. 27p.

Integration of Transcriptome and Metabolome Provides Unique Insights to Pathways Associated With Obese Breast Cancer Patients.

Autor: Hassan, Mohammed A., Al-Sakkaf, Kaltoom, Shait Mohammed, Mohammed Razeeth, Dallol, Ashraf, Al-Maghrabi, Jaudah, Aldahlawi, Alia, Ashoor, Sawsan, Maamra, Mabrouka, Ragoussis, Jiannis, Wu, Wei, Khan, Mohammad Imran, Al-Malki, Abdulrahman L., Choudhry, Hani

Publikováno v: Frontiers in Oncology; 5/19/2020, Vol. 11, p1-14, 14p