Výsledky vyhledávání - "Maayke A. J. H. van Ruler"

Screening for Potential Targets for Therapy in Mesenchymal, Clear Cell, and Dedifferentiated Chondrosarcoma Reveals Bcl-2 Family Members and TGF beta as Potential Targets

Autor: Adrienne M. Flanagan, Nicholas A. Athanasou, Jan Oosting, Brendy E.W.M. van den Akker, Judith V.M.G. Bovée, Pancras C.W. Hogendoorn, Maayke A. J. H. van Ruler, Jolieke G. van Oosterwijk, Andreas Leithner, Piero Picci, Tibor Krenács, Søren Daugaard, Danielle Meijer, Bernadette Liegl-Atzwanger

Publikováno v: American Journal of Pathology, 182(4), 1347-1356
American Journal of Pathology, 182(4), 1347-1356. Elsevier Inc.

The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely rare, together constituting 10% to 15% of all chondrosarcomas. Their poor prognosis and lack of efficacious treatment emphasizes the need to elucidate the pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94937e820bd88ac5012ffefb7c45e186
http://hdl.handle.net/1887/100194

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R132C IDH1 Mutations Are Found in Spindle Cell Hemangiomas and Not in Other Vascular Tumors or Malformations

Autor: Dina Lev, Valerie L. Luks, Maayke A. J. H. van Ruler, Alexander J. Lazar, Judith V.M.G. Bovée, Kyle C. Kurek, Twinkal C. Pansuriya, Sofie L. J. Verbeke, Raf Sciot, Harry P.W. Kozakewich, Brendy E.W.M. van den Akker, Christopher D.M. Fletcher

Publikováno v: American Journal of Pathology, 182(5), 1494-1500

Spindle cell hemangioma (SCH) is a rare, benign vascular tumor of the dermis and subcutis. The lesions can be multifocal and are overrepresented in Maffucci syndrome, in which patients also have multiple enchondromas. Somatic mosaic R132C IDH1 hotspo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51c13033d7a18f1b355628ac4e39c4
https://hdl.handle.net/1887/97102

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Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone

Autor: Isidro Machado, Carla S P van Rijswijk, P. D. Sander Dijkstra, Danielle de Jong, Maayke A. J. H. van Ruler, Pancras C.W. Hogendoorn, Antonio Llombart-Bosch, Karoly Szuhai, Judith V.M.G. Bovée, Jolieke G. van Oosterwijk

Publikováno v: BMC Cancer, 12
BMC Cancer
BMC Cancer, Vol 12, Iss 1, p 375 (2012)
BMC Cancer Vol. 12 pp. 375-375
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname

Background Chondrosarcoma is the second most common primary sarcoma of bone. High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome. In pre-clinical research aiming at the identification of novel treatment targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7fd3b0660a86668eb805f9dd496503
https://doi.org/10.1186/1471-2407-12-375

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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

Publikováno v: Nature Genetics, 43(12), 1256-U124. Nature Publishing Group
Nature genetics
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Nature Genetics, 43(12), 1256-U124

Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized by multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci syndrome). We report somatic heterozygous mutations in IDH1 (c.394C>T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813422f5c3e79f2b2db5a122df98d7bb
https://hdl.handle.net/10171/36487

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BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

Autor: Brendy E.W.M. van den Akker, Stephane Boeuf, Maayke A. J. H. van Ruler, Wiltrud Richter, Burkhard Lehner, Anne-Marie Cleton-Jansen, Judith V.M.G. Bovée

Publikováno v: BMC Cancer
BMC Cancer, 12
BMC Cancer, Vol 12, Iss 1, p 488 (2012)

Background As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ff754bd5c4479204341009901132f7

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