LifeTime and improving European healthcare through cell-based interceptive medicine

Autor: Rajewsky, N., Almouzni, G., Gorski, S., Aerts, S., Amit, I., Bertero, M., Bock, C., Bredenoord, A., Cavalli, G., Chiocca, S., Clevers, H., Strooper, B., Eggert, A., Ellenberg, J., Fernández, X., Figlerowicz, M., Gasser, S., Hubner, N., Kjems, J., Knoblich, J., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J., Marioni, J., Marti-Renom, M., Netea, M., Nickel, D., Nollmann, M., Novak, H., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F., Torres-Padilla, M., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M., Voet, T., Alberi, L., Alexander, S., Alexandrov, T., Arenas, E., Bagni, C., Balderas, R., Bandelli, A., Becher, B., Becker, M., Beerenwinkel, N., Benkirame, M., Beyer, M., Bickmore, W., Biessen, E., Blomberg, N., Blumcke, I., Bodenmiller, B., Borroni, B., Boumpas, D., Bourgeron, T., Bowers, S., Braeken, D., Brooksbank, C., Brose, N., Bruining, H., Bury, J., Caporale, N., Cattoretti, G., Chabane, N., Chneiweiss, H., Cook, S., Curatolo, P., de Jonge, M., Deplancke, B., de Witte, P., Dimmeler, S., Draganski, B., Drews, A., Dumbrava, C., Engelhardt, S., Gasser, T., Giamarellos-Bourboulis, E., Graff, C., Grün, D., Gut, I., Hansson, O., Henshall, D., Herland, A., Heutink, P., Heymans, S., Heyn, H., Huch, M., Huitinga, I., Jackowiak, P., Jongsma, K., Journot, L., Junker, J., Katz, S., Kehren, J., Kempa, S., Kirchhof, P., Klein, C., Koralewska, N., Korbel, J., Kühnemund, M., Lamond, A., Lauwers, E., Le Ber, I., Leinonen, V., Tobon, A., Lundberg, E., Lunkes, A., Maatz, H., Mann, M., Marelli, L., Matser, V., Matthews, P., Mechta-Grigoriou, F., Menon, R., Nielsen, A., Pagani, M., Pasterkamp, R., Pitkänen, A., Popescu, V., Pottier, C., Puisieux, A., Rademakers, R., Reiling, D., Reiner, O., Remondini, D., Ritchie, C., Rohrer, J., Saliba, A., Sanchez-Valle, R., Santosuosso, A., Sauter, A., Scheltema, R., Scheltens, P., Schiller, H., Schneider, A., Seibler, P., Sheehan-Rooney, K., Shields, D., Sleegers, K., Smit, A., Smith, K., Smolders, I., Synofzik, M., Tam, W., Teichmann, S., Thom, M., Turco, M., van Beusekom, H., Vandenberghe, R., den Hoecke, S., de Poel, I., van der Ven, A., van der Zee, J., van Lunzen, J., van Minnebruggen, G., Paesschen, W., van Swieten, J., van Vught, R., Verhage, M., Verstreken, P., Villa, C., Vogel, J., von Kalle, C., Walter, J., Weckhuysen, S., Weichert, W., Wood, L., Ziegler, A., Zipp, F.

Publikováno v: Nature
England
Nature, 587(7834), 377-386. Nature Publishing Group
Nature 587, 377–386 (2020)
Nature, Nature Publishing Group, 2020, 587 (7834), pp.377-386. ⟨10.1038/s41586-020-2715-9⟩
Nature, 587. Nature Research
Rajewsky, N, Almouzni, G, Gorski, S A, Aerts, S, Amit, I, Bertero, M G, Bock, C, Bredenoord, A L, Cavalli, G, Chiocca, S, Clevers, H, De Strooper, B, Eggert, A, Ellenberg, J, Fernández, X M, Figlerowicz, M, Gasser, S M, Hubner, N, Kjems, J, Knoblich, J A, Krabbe, G, Lichter, P, Linnarsson, S, Marine, J C, Marioni, J C, Marti-Renom, M A, Netea, M G, Nickel, D, Nollmann, M, Novak, H R, Parkinson, H, Piccolo, S, Pinheiro, I, Pombo, A, Popp, C, Reik, W, Roman-Roman, S, Rosenstiel, P, Schultze, J L, Stegle, O, Tanay, A, Testa, G, Thanos, D, Theis, F J, Torres-Padilla, M E, Valencia, A, Vallot, C, van Oudenaarden, A, Vidal, M, Voet, T & LifeTime Community Working Groups 2020, ' LifeTime and improving European healthcare through cell-based interceptive medicine ', Nature, vol. 587, pp. 377-386 . https://doi.org/10.1038/s41586-020-2715-9
Nature, 587, 377-386
Nature, 587, 7834, pp. 377-386
Nature 587(7834), 377-386 (2020). doi:10.1038/s41586-020-2715-9
LifeTime Community Working Groups 2020, ' LifeTime and improving European healthcare through cell-based interceptive medicine ', Nature, vol. 587, no. 7834, pp. 377-386 . https://doi.org/10.1038/s41586-020-2715-9
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Rajewsky, N, Almouzni, G, Gorski, S A, Aerts, S, Amit, I, Bertero, M G, Bock, C, Bredenoord, A L, Cavalli, G, Chiocca, S, Clevers, H, de Strooper, B, Eggert, A, Ellenberg, J, Fernández, X M, Figlerowicz, M, Gasser, S M, Hubner, N, Kjems, J R, Knoblich, J R A, Krabbe, G, Lichter, P, Linnarsson, S, Marine, J-C, Marioni, J, Marti-Renom, M A, Netea, M G, Nickel, D R, Nollmann, M, Novak, H R, Parkinson, H, Piccolo, S, Pinheiro, I, Pombo, A, Popp, C, Reik, W, Roman-Roman, S, Rosenstiel, P, Schultze, J L, Stegle, O, Tanay, A, Testa, G, Thanos, D, Theis, F J, Torres-Padilla, M-E, Valencia, A, Vallot, C L, van Oudenaarden, A, Vidal, M, Voet, T & LifeTime Community 2020, ' LifeTime and improving European healthcare through cell-based interceptive medicine ', Nature, vol. 587, no. 7834, pp. 377-386 . https://doi.org/10.1038/s41586-020-2715-9
Nature, 587 (7834)
Nature: international weekly journal of science, 587(7834)

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83a48c0915b263383b56fe48dbb757
https://hdl.handle.net/10033/622882

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Autor: Muus, C, Luecken, MD, Eraslan, G, Sikkema, L, Waghray, A, Heimberg, G, Kobayashi, Y, Vaishnav, ED, Subramanian, A, Smillie, C, Jagadeesh, KA, Duong, ET, Fiskin, E, Triglia, ET, Ansari, M, Cai, P, Lin, B, Buchanan, J, Chen, S, Shu, J, Haber, AL, Chung, H, Montoro, DT, Adams, T, Aliee, H, Allon, SJ, Andrusivova, Z, Angelidis, I, Ashenberg, O, Bassler, K, Bécavin, C, Benhar, I, Bergenstråhle, J, Bergenstråhle, L, Bolt, L, Braun, E, Bui, LT, Callori, S, Chaffin, M, Chichelnitskiy, E, Chiou, J, Conlon, TM, Cuoco, MS, Cuomo, ASE, Deprez, M, Duclos, G, Fine, D, Fischer, DS, Ghazanfar, S, Gillich, A, Giotti, B, Gould, J, Guo, M, Gutierrez, AJ, Habermann, AC, Harvey, T, He, P, Hou, X, Hu, L, Hu, Y, Jaiswal, A, Ji, L, Jiang, P, Kapellos, TS, Kuo, CS, Larsson, L, Leney-Greene, MA, Lim, K, Litviňuková, M, Ludwig, LS, Lukassen, S, Luo, W, Maatz, H, Madissoon, E, Mamanova, L, Manakongtreecheep, K, Leroy, S, Mayr, CH, Mbano, IM, McAdams, AM, Nabhan, AN, Nyquist, SK, Penland, L, Poirion, OB, Poli, S, Qi, C, Queen, R, Reichart, D, Rosas, I, Schupp, JC, Shea, CV, Shi, X, Sinha, R, Sit, RV, Slowikowski, K, Slyper, M, Smith, NP, Sountoulidis, A, Strunz, M, Sullivan, TB, Sun, D, Talavera-López, C, Tan, P, Tantivit, J, Travaglini, KJ, Tucker, NR, Vernon, KA, Wadsworth, MH, Waldman, J, Wang, X, Xu, K, Yan, W, Zhao, W, Ziegler, CGK, NHLBI LungMap Consortium, Human Cell Atlas Lung Biological Network

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::b0bcc85331e84b5df1d0e1898c3be63e
https://hdl.handle.net/10453/152907

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