A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.

Autor: van der Krift F; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht, The Netherlands., Zijlmans DW; Department of Molecular Biology and Oncode Institute, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands., Shukla R; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Javed A; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands., Koukos PI; Computational Structural Biology, Bijvoet Centre for Biomolecular Research, Faculty of Science, Department of Chemistry, Utrecht University, Utrecht, The Netherlands., Schwarz LL; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht, The Netherlands., Timmermans-Sprang EP; Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands., Maas PE; Specs Compound Handling B.V., Zoetermeer, The Netherlands., Gahtory D; BIMINI Biotech B.V., Leiden, The Netherlands., van den Nieuwboer M; BIMINI Biotech B.V., Leiden, The Netherlands., Mol JA; Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands., Strous GJ; Center for Molecular Medicine, Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands., Bonvin AM; Computational Structural Biology, Bijvoet Centre for Biomolecular Research, Faculty of Science, Department of Chemistry, Utrecht University, Utrecht, The Netherlands., van der Stelt M; Department of Molecular Physiology and Oncode Institute, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands., Veldhuizen EJ; Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands., Weingarth M; NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Vermeulen M; Department of Molecular Biology and Oncode Institute, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands., Klumperman J; Center for Molecular Medicine, Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands., Maurice MM; Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht, The Netherlands M.M.Maurice@umcutrecht.nl.

Publikováno v: Life science alliance [Life Sci Alliance] 2023 Aug 17; Vol. 6 (11). Date of Electronic Publication: 2023 Aug 17 (Print Publication: 2023).