Bcl-2 is a critical mediator of intestinal transformation

Autor: Maartje van der Heijden, Cheryl D. Zimberlin, Anna M. Nicholson, Selcuk Colak, Richard Kemp, Sybren L. Meijer, Jan Paul Medema, Florian R. Greten, Marnix Jansen, Douglas J. Winton, Louis Vermeulen

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the

Externí odkaz: https://doaj.org/article/79fa743e4cb74ee29cb645e41f5d7283

Supplementary Video 1 from Dishevelled 2 Signaling Promotes Self-Renewal and Tumorigenicity in Human Gliomas

Autor: Alan Hall, Viviane Tabar, Jason T. Huse, Leif A. Droms, Maartje Van Der Heijden, Teodoro Pulvirenti

AVI file - 3.1MB, Time-lapse live video microscopy of U87 glioma cells infected with control shRNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96039b65e0007fbcde781fde73e3af1f
https://doi.org/10.1158/0008-5472.22389713

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

Autor: Erik van Dijk, Jan Paul Medema, Bauke Ylstra, Daniël M. Miedema, Kristiaan J. Lenos, Veronique L. Veenstra, Lisanne E. Nijman, Maartje van der Heijden, Sanne M. van Neerven, Nina E. de Groot, Martin A. Nowak, Douglas J. Winton, Andrea Arricibita Varea, Bartlomiej Waclaw, Edward Morrissey, Maarten F. Bijlsma, Maria C. Lecca, Pramudita R. Prasetyanti, Sophie C. Lodestijn, Louis Vermeulen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 116(13), 6140-6145. National Academy of Sciences
van der Heijden, M, Miedema, D, Waclaw, B, Veenstra, V, Lecca, M, Nijman, L, Dijk, E, van Neerven, S, Lodestijn, S, Lenos, K, de Groot, N, Prasetyanti, P, Arricibita Varea, A, Winton, D, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M, Bijlsma, M & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
van der Heijden, M, Miedema, D M, Waclaw, B, Veenstra, V L, Lecca, M C, Nijman, L E, van Dijk, E, van Neerven, S M, Lodestijn, S C, Lenos, K J, de Groot, N E, Prasetyanti, P R, Varea, A A, Winton, D J, Medema, J P, Morrissey, E, Ylstra, B, Nowak, M A, Bijlsma, M F & Vermeulen, L 2019, ' Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 13, pp. 6140-6145 . https://doi.org/10.1073/pnas.1813417116

Significance Colorectal cancer (CRC) is a heterogeneous disease, with significant variation in genotype and phenotype within each individual tumor. This intratumor heterogeneity emerges during tumor development due to clonal evolution and in part can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3067c66ea779680d543b2321a5015fc
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063961772&origin=inward

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Autor: Sophie C. Lodestijn, Xavier Romero Ros, Douglas J. Winton, Felipe De Sousa E Melo, Maarten F. Bijlsma, Kristiaan J. Lenos, Jan Paul Medema, Nicolas Léveillé, Filipe C. Lourenco, Lianne Koens, Guillaume Hypolite, Daniël M. Miedema, Maartje van der Heijden, Giorgio Stassi, Lisanne E. Nijman, Scott K. Lyons, Louis Vermeulen, Tom van den Bosch, Joy Otten, Patrick Veerman, Ronja S. Adam, Anita van Oort, Maria C. Lecca, Edward Morrissey, Sanne M. van Neerven

Publikováno v: Nature cell biology
Nature cell biology, 20(10), 1193-1202. Nature Publishing Group
Nature Cell Biology

Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses of lineage tracing data from primary colon cancer xenograft tissue to assess CSC functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e147179d3f464827f43d148a2bc312
http://europepmc.org/articles/PMC6163039

A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies

Autor: Maartje van der Heijden, Louis Vermeulen

Publikováno v: Resistance to Targeted Anti-Cancer Therapeutics ISBN: 9783030166236

Minimal residual disease (MRD) is a major difficulty in clinical oncology. It refers to the situation in which seemingly successful therapy is followed by a period of clinical complete remission after which the tumor eventually relapses. This course

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb809851d0aabf2765cf4a3b1707f6f5
https://doi.org/10.1007/978-3-030-16624-3_2