Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maarten van der Kroef"'
Autor:
Barbara Mariotti, Nila Hendrika Servaas, Marzia Rossato, Nicola Tamassia, Marco A. Cassatella, Marta Cossu, Lorenzo Beretta, Maarten van der Kroef, Timothy R. D. J. Radstake, Flavia Bazzoni
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
TLR4 activation initiates a signaling cascade leading to the production of type I IFNs and of the downstream IFN-stimulated genes (ISGs). Recently, a number of IFN-induced long non-coding RNAs (lncRNAs) that feed-back regulate the IFN response have b
Externí odkaz:
https://doaj.org/article/0693f1abc33f4f1ab96c405ef37fd30e
Autor:
Tiago Carvalheiro, Marzia Rossato, Marta Cossu, Catherina G.K. Wichers, Lorenzo Beretta, Eleni Chouri, Jonas J.W. Kuiper, Femke Bonte-Minheur, Sandra C Silva-Cardoso, Nila H. Servaas, Anneline C Hinrichs, Timothy R D J Radstake, Aridaman Pandit, Nadia Vazirpanah, Alsya J. Affandi, Maarten van der Kroef, Cornelis P. J. Bekker, Andrea Ottria, Marianne Boes, Sanne Hiddingh
Publikováno v:
Arthritis and Rheumatology. John Wiley and Sons Ltd
ObjectivesTo identify key disease pathways driving conventional dendritic cell (cDC) alterations in Systemic Sclerosis (SSc).MethodsTranscriptomic profiling was performed on peripheral blood CD1c+ cDCs (cDC2s) isolated from 12 healthy donors and 48 S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f44e5944c3ffe699cec9a70c44ca8b1
https://doi.org/10.1002/art.42319
https://doi.org/10.1002/art.42319
Autor:
Sanne Hiddingh, Laura M. Timmerman, Timothy R D J Radstake, Robert Jan Lebbink, Ruth D E Fritsch-Stork, William Khoury-Hanold, Ellen D. Kaan, Michiel van der Vlist, F. Peters, Linde Meyaard, Lucas L van den Hoogen, M. Inês Pascoal Ramos, Maarten van der Kroef, Titus A. P. de Hond
Publikováno v:
Science Signaling. 14
CD200 receptor 1 (CD200R) is an inhibitory immunoreceptor that suppresses Toll-like receptor (TLR)–induced cytokine production through the adaptor protein Dok2 and the GTPase activating protein (GAP) p120-RasGAP, which can be cleaved during mild ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9f02fdad51a32f20b0ac09976f9d46
https://doi.org/10.1126/scisignal.abb4324
https://doi.org/10.1126/scisignal.abb4324
Autor:
Nila H. Servaas, Timothy R D J Radstake, Flavia Bazzoni, Barbara Mariotti, Maarten van der Kroef, Catharina G.K. Wichers, Aridaman Pandit, Marzia Rossato
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4365, p 4365 (2021)
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4365, p 4365 (2021)
Systemic sclerosis (SSc) is a chronic autoimmune disease mainly affecting the connective tissue. In SSc patients, monocytes are increased in circulation, infiltrate affected tissues, and show a pro-inflammatory activation status, including the so-cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fc9a88276beb9372daf3cfe4d01274
https://pubmed.ncbi.nlm.nih.gov/33922041
https://pubmed.ncbi.nlm.nih.gov/33922041
Autor:
Aridaman Pandit, Fatiha Zaaraoui-Boutahar, Sandra C Silva-Cardoso, Rina Kommer-Wichers, Femke van Wijk, Timothy R D J Radstake, Maarten van der Kroef, Andrea Ottria, Eleni Chouri, Arno C. Andeweg, Tiago Ferreira-Carvalheiro, Alsya J. Affandi, Nila H. Servaas
Publikováno v:
Journal of Autoimmunity, 117:102574. Academic Press Inc.
Journal of Autoimmunity, 117:102574. Academic Press
Servaas, N H, Zaaraoui-Boutahar, F, Wichers, C G K, Ottria, A, Chouri, E, Affandi, A J, Silva-Cardoso, S, van der Kroef, M, Carvalheiro, T, van Wijk, F, Radstake, T R D J, Andeweg, A C & Pandit, A 2021, ' Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis ', Journal of Autoimmunity, vol. 117, 102574, pp. 102574 . https://doi.org/10.1016/j.jaut.2020.102574
Journal of Autoimmunity, 117:102574. Academic Press
Servaas, N H, Zaaraoui-Boutahar, F, Wichers, C G K, Ottria, A, Chouri, E, Affandi, A J, Silva-Cardoso, S, van der Kroef, M, Carvalheiro, T, van Wijk, F, Radstake, T R D J, Andeweg, A C & Pandit, A 2021, ' Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis ', Journal of Autoimmunity, vol. 117, 102574, pp. 102574 . https://doi.org/10.1016/j.jaut.2020.102574
The T-cell receptor (TCR) is a highly polymorphic surface receptor that allows T-cells to recognize antigenic peptides presented on the major histocompatibility complex (MHC). Changes in the TCR repertoire have been observed in several autoimmune con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4885dde4a3f40125845a63b7ec908c43
https://pure.eur.nl/en/publications/31ba94d0-2118-4e5e-b16a-646a0c9fb914
https://pure.eur.nl/en/publications/31ba94d0-2118-4e5e-b16a-646a0c9fb914
Autor:
Lorenzo Beretta, Sandra C Silva-Cardoso, Maarten R Hillen, Eleni Chouri, Marta Cossu, Boudewijn M.T. Burgering, Joel A G van Roon, Marzia Rossato, Alsya J. Affandi, Maojie Wang, Aridaman Pandit, Timothy R D J Radstake, Tiago Carvalheiro, Lenny van Bon, Chiara Angiolilli, Maarten van der Kroef, Catharina G.K. Wichers, Cornelis P. J. Bekker
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 491, p 491 (2021)
Chouri, E, Wang, M, Hillen, M R, Angiolilli, C, Silva-Cardoso, S C, Wichers, C G K, van der Kroef, M, Bekker, C P J, Cossu, M, van Bon, L, Affandi, A J, Carvalheiro, T, Pandit, A, van Roon, J A G, Beretta, L, Burgering, B M T, Radstake, T R D J & Rossato, M 2021, ' Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis ', Journal of Clinical Medicine, vol. 10, no. 3, 491, pp. 1-20 . https://doi.org/10.3390/jcm10030491
Journal of Clinical Medicine
Volume 10
Issue 3
Journal of Clinical Medicine, 10(3):491, 1-20
Chouri, E, Wang, M, Hillen, M R, Angiolilli, C, Silva-Cardoso, S C, Wichers, C G K, van der Kroef, M, Bekker, C P J, Cossu, M, van Bon, L, Affandi, A J, Carvalheiro, T, Pandit, A, van Roon, J A G, Beretta, L, Burgering, B M T, Radstake, T R D J & Rossato, M 2021, ' Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis ', Journal of Clinical Medicine, vol. 10, no. 3, 491, pp. 1-20 . https://doi.org/10.3390/jcm10030491
Journal of Clinical Medicine
Volume 10
Issue 3
Journal of Clinical Medicine, 10(3):491, 1-20
Compelling evidence shows the involvement of plasmacytoid dendritic cells (pDCs) in systemic sclerosis (SSc) pathogenesis. This study investigated whether microRNAs (miRNAs) are involved in the dysregulation of pDCs in SSc patients already at early s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3838edea592c976e1597fa47cf46102
https://www.mdpi.com/2077-0383/10/3/491
https://www.mdpi.com/2077-0383/10/3/491
Autor:
Wioleta Marut, Tiago Carvalheiro, Femke Bonte-Mineur, Jose M Pego-Reigosa, Beatriz Malvar-Fernandez, Carlos Rafael-Vidal, Timothy R D J Radstake, Maili Zimmermann, Maarten van der Kroef, Lorenzo Beretta, Samuel Garcia, Anneline C Hinrichs, Marc R. Kok, Ana P Lopes, Nila H. Servaas
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9544, p 9544 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences
Volume 21
Issue 24
Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923bd789c7b899285ec89dd16c72a52b
https://www.mdpi.com/1422-0067/21/24/9544
https://www.mdpi.com/1422-0067/21/24/9544
Autor:
Marta Cossu, Floor de Wit, Chiara Angiolilli, Maarten van der Kroef, Eleni Chouri, Catharina G.K. Wichers, Tiago Carvalheiro, Elena Trombetta, Marzia Rossato, Cornelis P. J. Bekker, Lorenzo Beretta, Nadia Vazirpanah, Timothy R D J Radstake
Objective To analyze how monocyte and macrophage exposure to CXCL4 induces inflammatory and fibrotic processes observed in Systemic sclerosis (SSc) patients. Methods In six independent experiments, monocytes of healthy controls (HC) and SSc patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7493cc12f005e908b1e22dff48e46161
http://hdl.handle.net/11562/1034819
http://hdl.handle.net/11562/1034819
Autor:
Timothy R D J Radstake, Chiara Angiolilli, Maarten van der Kroef, Kris A. Reedquist, Wioleta Marut, Eleni Chouri
Publikováno v:
Nature Reviews Rheumatology. 14:657-673
Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular abnormalities, immunological alterations and fibrosis of the skin and internal organs. The results of genetic studies in patients with SSc have revealed statist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b6066a0e8edd963eb9ed5b894573be
https://doi.org/10.1038/s41584-018-0099-0
https://doi.org/10.1038/s41584-018-0099-0
Autor:
Wioleta Marut, Femke Wolters, Joel A G van Roon, Lorenzo Beretta, Sandra C Silva-Cardoso, Catharina G.K. Wichers, Jacob M van Laar, Soley Thordardottir, Cornelis P. J. Bekker, Eleni Chouri, Marta Cossu, Lenny van Bon, Kris A. Reedquist, Javier Martín, Maarten van der Kroef, Alsya J. Affandi, Lara Bossini-Castillo, Jasper C A Broen, Timothy R D J Radstake, Frederique M Moret, Marzia Rossato, Harry Dolstra
Publikováno v:
Arthritis & Rheumatology. 69:1891-1902
OBJECTIVE: Plasmacytoid dendritic cells (PDCs) are a critical source of type I interferons (IFNs) that can contribute to the onset and maintenance of autoimmunity. Molecular mechanisms leading to PDC dysregulation and a persistent type I IFN signatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f023bfd29484966a5cc16c69f130be9
https://doi.org/10.1002/art.40163
https://doi.org/10.1002/art.40163