Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Maarten Rotman"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 123-123 (2023)
OBJECTIVES/GOALS: The goal of the Hatchery is a new approach to de-risk innovative life science ideas within an entrepreneurial setting. The Hatchery creates value by vetting the initial potential through experimental testing. METHODS/STUDY POPULATIO
Externí odkaz:
https://doaj.org/article/67413c2aca364541ad200ca69417931e
Autor:
Rob J A Nabuurs, Kim S Rutgers, Mick M Welling, Athanasios Metaxas, Maaike E de Backer, Maarten Rotman, Brian J Bacskai, Mark A van Buchem, Silvère M van der Maarel, Louise van der Weerd
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38284 (2012)
This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits characteristic for Alzheimer's disease and cerebral amyloid angiopathy.
Externí odkaz:
https://doaj.org/article/345936b88cb54209aa94fbd068f64428
Autor:
Mads Kjolby, Peter Breining, Karen Pedersen, Niels Wellner, Karen Sørensen, Anette Gjessing, Dovile Januliene, Dorthe Vittrup, Arulmani Manavalan, Maarten Rotman, Gangadaar Thotakura, Guido Hermey, Peder Madsen, Christian Vaegter, Søren Thirup, Olof Asplund, Rashmi Prasad, Edwin Parlevliet, Patrick Rensen, Andreas Madsen, Birgitte Holst, Olav Andersen, Arne Moller, Torben Hansen, Anders Nykjaer
Type 2 diabetes has reached endemic proportions and is a substantial burden for the affected patients and the society. Along with lifestyle factors, a number of genetic loci predisposing to type 2 diabetes have been identified, including SORCS1 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec672209d92bb95a06749b31dbc88c6e
https://doi.org/10.21203/rs.3.rs-1299440/v1
https://doi.org/10.21203/rs.3.rs-1299440/v1
Autor:
J. Nathan Cantrell, Jennifer L. Peterson, Steven S. Rosenfeld, Alfredo Quinones-Hinojosa, Henry Ruiz-Garcia, Maarten Rotman, Michael G. Heckman, Mark R. Waddle, Paul D. Brown, Daniel M. Trifiletti
Publikováno v:
Mayo Clinic Proceedings. 94:1278-1286
To identify the frequency and characteristics of long-term survivors of glioblastoma.Using all cases of glioblastoma with histopathological confirmation in the National Cancer Database from January 1, 2004, through December 31, 2009, clinical, instit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fee593f5a65008384749a04b5b1b0c
https://doi.org/10.1016/j.mayocp.2018.11.031
https://doi.org/10.1016/j.mayocp.2018.11.031
Autor:
Rashmi B. Prasad, Torben Hansen, Patrick C.N. Rensen, Sune Skeldal, Dorthe Maria Vittrup, Karen M. Pedersen, Olof Asplund, Christian Bjerggaard Vaegter, Anette Marianne Prior Gjessing, Andreas N. Madsen, Karen Marie Juul Sørensen, Mads Kjolby, Maarten Rotman, Dovile Januliene, Olav M. Andersen, Guido Hermey, Edwin T. Parlevliet, Birgitte Holst, Arne Moller, Gangadaar Thotakura, Ernst-Martin Füchtbauer, Søren Thirup, Peder Madsen, Niels Wellner, Peter Breining, Arulmani Manavalan
Type II diabetes mellitus (T2DM) has reached endemic levels and comprises a substantial burden to the patient and the society. Along with lifestyle factors, a number of genetic loci predisposing to T2DM have been suggested including SORCS1 that encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbdadf328d061149c37f06c00ea13f49
https://doi.org/10.1101/2020.11.10.376178
https://doi.org/10.1101/2020.11.10.376178
Publikováno v:
Drug Discovery Today: Technologies. 8:e117-e125
Optical and magnetic resonance imaging have the potential to be complementary non-invasive imaging modalities. Yet without advances in imaging technologies and contrast agents both have short-comings that cannot be ignored. In this review we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1568f8d246b6106b3910b53504495ce
https://doi.org/10.1016/j.ddtec.2011.11.005
https://doi.org/10.1016/j.ddtec.2011.11.005
Autor:
Bram Dorresteijn, Ernst Suidgeest, Maarten Rotman, Silvère M. van der Maarel, Louise van der Weerd, C.T. Verrips, Mohamed El Khattabi, Ruud Schravesande, Dorien Faber
Publikováno v:
FEBS Journal, 282(18), 3618-3631
UNLABELLED Accumulation and aggregation of the amyloid-β (Aβ) peptide is associated with Alzheimer's disease (AD). Aβ is generated from the amyloid precursor protein by the successive action of two membrane-associated processing enzymes: β-secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd67cf272d6e799c85ddd09aa70efea
https://hdl.handle.net/1887/106489
https://hdl.handle.net/1887/106489
Autor:
Maarten Rotman, Linda M. van der Graaf, Mick M. Welling, Laure Grand Moursel, Marlinde L. van den Boogaard, Mark A. van Buchem, Louise van der Weerd, Silvère M. van der Maarel
Publikováno v:
Nuclear Medicine and Biology, 42(8), 695-702
Introduction Llama single domain antibody fragments (VHH), which can pass endothelial barriers, are being investigated for targeting amyloid plaque load in Alzheimer's disease (AD). Contrary to conventional human or murine antibodies consisting of Ig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee973df1c60998b6e15b39f687fa808
https://hdl.handle.net/1887/106504
https://hdl.handle.net/1887/106504
Autor:
Maarten Rotman, Maaike E. de Backer, Mick M. Welling, Anton Bunschoten, Silvère M. van der Maarel, Jaap Rip, Louise van der Weerd, Mark A. van Buchem, Pieter J. Gaillard, Rob J.A. Nabuurs
Publikováno v:
Journal of Controlled Release, 203, 40-50
Treatment of neurodegenerative disorders such as Alzheimer's disease is hampered by the blood-brain barrier (BBB). This tight cerebral vascular endothelium regulates selective diffusion and active transport of endogenous molecules and xenobiotics int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8fd285552d2e94c8ac5775020490b
https://hdl.handle.net/1887/101871
https://hdl.handle.net/1887/101871
Autor:
Jordan J. Green, Maarten Rotman, Rawan Al-kharboosh, Alfredo Quinones-Hinojosa, Nicholas Ellens, Katarina Cheng
Publikováno v:
Neuro-Oncology. 19:vi227-vi227
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad88a1bc1035c9141d5d517dd4bef44
https://doi.org/10.1093/neuonc/nox168.921
https://doi.org/10.1093/neuonc/nox168.921