Výsledky vyhledávání - "Maarten Robert Egmond"

Phosphonate analogues of triacylglycerols are potent inhibitors of lipase

Autor: G.H. de Haas, Maarten Robert Egmond, H. T. W. M. van der Hijden, A.T. Slotboom, M. L. M. Mannesse, J.-W.P. Boots, R. Dijkman, Hubertus M. Verheij

Publikováno v: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1259:56-64

1,2-Dioctylcarbamoylglycero-3-O-p-nitrophenyl alkylphosphonates, with alkyl being methyl or octyl, were synthesised and tested as irreversible inhibitors of cutinase from Fusarium solani pisi and Staphylococcus hyicus lipase. Rapid inactivation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891dc74633e1ce003ba98c3ad7124d64
https://doi.org/10.1016/0005-2760(95)00145-3

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Cutinase from Fusarium solani pisi Hydrolyzing Triglyceride Analogs. Effect of Acyl Chain Length and Position in the Substrate Molecule on Activity and Enantioselectivity

Autor: G.H. de Haas, J. De Vlieg, Bart C. Koops, H. T. W. M. Van Der Hijden, Maarten Robert Egmond, Hubertus M. Verheij, Ruud C. Cox, M. L. M. Mannesse

Publikováno v: Biochemistry. 34:6400-6407

Triglyceride analogues were synthesized in which one of the primary acyl ester functions has been replaced by an alkyl group and the secondary acyl ester bond has been replaced by an acyl amino bond. The chain length at either position was varied, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98649888a11d3dfbbd5afe4d7bdf60bf
https://doi.org/10.1021/bi00019a020

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Chiral preference of cutinase in the reaction with phosphonate inhibitors

Autor: G.H. de Haas, Hubertus M. Verheij, Maarten Robert Egmond, H. T. W. M. van der Hijden, M. L. M. Mannesse

Publikováno v: Biochemical Society transactions. 25(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08df56c19e2ec12879f165cb94232005
https://pubmed.ncbi.nlm.nih.gov/9056864

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Engineering Surface Charges in a Subtilisin

Autor: P. Ravestein, Maarten Robert Egmond, J. de Vlieg, W. P. Antheunisse, A. T. A. Mooren

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780306451089

Introduction of multiple charged amino acid residues in the subtilisin Savinase by genetic engineering allowed us to modify the electrostatic properties of this enzyme in a systematic way. The effects of these charge changes were investigated theoret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bce39bc75922bbd846544bf318c4981
https://doi.org/10.1007/978-1-4613-0319-0_23

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