Výsledky vyhledávání - "Maarten P. Hazenberg"

Peptidoglycan from sterile human spleen induces T-cell proliferation and inflammatory mediators in rheumatoid arthritis patients and healthy subjects

Autor: Ingrid A. Schrijver, Ghislain Opdenakker, Jon D. Laman, Marie-José Melief, H.M. Markusse, I Van Aelst, Maarten P. Hazenberg

Publikováno v: Rheumatology. 40:438-446

textabstractOBJECTIVES: Peptidoglycan (PG), a component of Gram-positive bacteria, may be involved in rheumatoid arthritis (RA) because of its ability to induce production of proinflammatory cytokines, to induce arthritis in rodents, and its presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b58231675a9aeaf63cdc6eaa162226
https://doi.org/10.1093/rheumatology/40.4.438

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Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines

Autor: Maarten P. Hazenberg, Paul P. Tak, Marie-José Melief, Jon D. Laman, Ingrid A. Schrijver

Publikováno v: Arthritis and rheumatism, 43(10), 2160-2168. John Wiley and Sons Inc.

Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by intimal lining hyperplasia and massive infiltration of the synovial sublining by antigen-presenting cells (APCs), lymphocytes, and plasma cells. Peptidoglycan (PG)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7481ca46d448fe128323dcd265f858
https://doi.org/10.1002/1529-0131(200010)43:10<2160::aid-anr3>3.0.co

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Reduced systemic IgG levels against peptidoglycan in rheumatoid arthritis (RA) patients

Autor: Marie-José Melief, Ingrid A. Schrijver, J.M. van Laar, Jon D. Laman, I. S. Klasen, Y. A. De Man, H. M. Markusse, Maarten P. Hazenberg

Publikováno v: Clinical & Experimental Immunology, 122, 1-8. Wiley-Blackwell Publishing Ltd

SUMMARY The gut flora is believed to play a role in the pathogenesis of RA. Peptidoglycan, a major cell wall component of Gram-positive bacteria, is a candidate antigen because of its capability to trigger production of proinflammatory cytokines, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4f39b22ccb50e849ce10e066e154a0
https://pure.eur.nl/en/publications/81b66d07-a712-44cf-87a0-1181f3ce0128

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Isolation and characterization of the viscous, high-molecular-mass microbial carbohydrate fraction from faeces of healthy subjects and patients with Crohn's disease and the consequences for a therapeutic approach

Autor: Maarten P. Hazenberg, Doede J. Binnema, Leo M. C. van Lieshout, Johanneke G. H. Ruseler-van Embden

Publikováno v: Clinical Science, 95, 425-433. Portland Press, Ltd.

1.An earlier study by our group revealed that the viscosity of faeces from patients with Crohn's disease is significantly lower than that of healthy subjects. This is due to low concentrations of a high-molecular-mass carbohydrate, probably of bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b465f9dc43bc9d34f655a2bc55ef359
https://pure.eur.nl/en/publications/d7fa3a0e-e456-4258-a2a3-4347067b7fd9

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Expression and Intracellular Localization of the Human N-acetylmuramyl-L-alanine Amidase, a Bacterial Cell Wall–Degrading Enzyme

Autor: Maarten P. Hazenberg, Marie-José Melief, J. Calafat, R.W.M. van den Beemd, Maarten A. Hoijer, D. Roos, J. J. M. Van Dongen

Publikováno v: Blood. 90:1246-1254

N-acetylmuramyl-L-alanine amidase (NAMLAA) specifically degrades peptidoglycan, which is a major component of bacterial cell walls with strong inflammatory properties. For instance, peptidoglycan is capable of stimulating peripheral blood cells to re

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https://doi.org/10.1182/blood.v90.3.1246

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Anti-GM1 IgG antibodies and campylobacter bacteria in Guillain-Barré syndrome: Evidence of molecular mimicry

Autor: J. R. J. Bänffer, Bart C. Jacobs, Maarten P. Hazenberg, P. G. Oomes, F. G. A. Van Der Meche

Publikováno v: Annals of Neurology. 38:170-175

In Guillain-Barré syndrome antibodies to GM1 and the presence of an antecedent Campylobacter jejuni infection are correlated with a more severe course of the disease. From a group of 137 consecutive GBS patients, 11 sera had elevated titers of anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f13909e17b27ad8644ce4b40435120
https://doi.org/10.1002/ana.410380208

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Detection of muramic acid in a carbohydrate fraction of human spleen

Autor: Maarten A. Hoijer, Maarten P. Hazenberg, Marie-José Melief, F. Eulderink, C.G. van Helden-Meeuwsen

Publikováno v: Infection and Immunity. 63:1652-1657

In previous studies, we showed that peptidoglycan polysaccharides from anaerobic bacteria normally present in the human gut induced severe chronic joint inflammation in rats. Our hypothesis is that peptidoglycan from the gut flora is involved in perp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7dfc869579b9da43472b5d73dc4804
https://doi.org/10.1128/iai.63.5.1652-1657.1995

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Serum anti-GQ1bIgG antibodies recognize surface epitopes onCampylobacter jejunifrom patients with Miller Fisher syndrome

Autor: P.A. van Doorn, Hubert P. Endtz, Maarten P. Hazenberg, F. G. A. Van Der Meche, H. A. M. Achtereekte, Bart C. Jacobs

Publikováno v: Annals of Neurology. 37:260-264

Three patients who had diarrhea prior to the development of Miller Fisher syndrome are presented. Campylobacter jejuni was isolated from stool specimens from all patients. High titers of anti-GQ1b IgG antibodies were demonstrated in the serum of thes

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https://doi.org/10.1002/ana.410370218

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PRESENCE OF BACTERIAL FLORA-DERIVED ANTIGEN IN SYNOVIAL TISSUE MACROPHAGES AND DENDRITIC CELLS

Autor: Marie-José Melief, Maarten P. Hazenberg, H.C. van Paassen, Maarten A. Hoijer

Publikováno v: Rheumatology. 34:1112-1116

In previous studies using and animal model human bacterial flora-derived peptidoglycan Polysaccharides were shown to be arthropathic after a single subcutaneous injection. A prerequisite for proof of the hypothesis that bacterial products from the no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaf362cef0bf0bdfa1ef454dd88d48d
https://doi.org/10.1093/rheumatology/34.12.1112

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The Presence of Peptidoglycan-Polysaccharide Complexes in the Bowel Wall and the Cellular Responses to These Complexes in Crohn's Disease

Autor: I. S. Klasen, Maarten P. Hazenberg, Marie-José Melief, G. Hoke, H. Hooijkaas, W.R. Schouten, H. de Visser, A.G.S. van Halteren, M. van Blankenstein

Publikováno v: Clinical Immunology and Immunopathology. 71:303-308

Interestingly, using a monoclonal antibody, peptidoglycan-polysaccharide complexes (PPC) were detected intracellularly in the mucosa and submucosa of the bowel wall of Crohn's disease (CD) patients. PPC are the main constituents of the gram-positive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cb8a981c112cf7cd83b72146755d9b
https://doi.org/10.1006/clin.1994.1090

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