Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Maarten L. van Roosmalen"'
Autor:
Margriet Dijkstra-Tiekstra, Peter J. M. Openshaw, Mohini Kalyan, Maarten L. van Roosmalen, Roberto Grimaldi, Christopher Chiu, Bert-Jan Haijema, Kees Leenhouts, Qibo Zhang, Muhammad S Ahmed, Iris T. Vlachantoni, Sanna Wallin-Weber, Stephanie Ascough
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
RATIONALE:Needle-free intranasal vaccines offer major potential advantages, especially against pathogens entering via mucosal surfaces. As yet, there is no effective vaccine against respiratory syncytial virus (RSV), a ubiquitous pathogen of global i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f83af1a3603b790c70fff27a2354296
https://doi.org/10.1164/rccm.201810-1921oc
https://doi.org/10.1164/rccm.201810-1921oc
Autor:
Maarten L. van Roosmalen, Shannon J. Heine, Marcela F. Pasetti, Olga L. Franco-Mahecha, Kees Leenhouts, Wendy L. Picking, Cinthia B. Drachenberg, Khandra T. Sears
Publikováno v:
The Journal of Immunology. 202:2005-2016
Yersinia enterocolitica causes a severe enteric infection in infants and young children. There is no vaccine approved for use in humans. We investigated the immunogenicity and protective capacity of Yersinia YopB, a conserved type III secretion syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40af634741915859973b855fb9aabbd3
https://doi.org/10.4049/jimmunol.1800985
https://doi.org/10.4049/jimmunol.1800985
Autor:
Chunlai Jiang, Dandan Wang, Yongge Wu, Tiejun Gu, Wei Kong, Jingcai Lu, Kees Leenhouts, Jinfei Yu, Maarten L. van Roosmalen, Hongjia Hou
Publikováno v:
Immunological Investigations. 47:403-415
Streptococcus pneumoniae is a major pathogen accounting for a large number of pneumococcal disease in worldwide. Due to the mucosal immune pathway induces both systemic and mucosal immune responses, the potential strategy to prevent pneumococcal dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba61f9f3330e810016b95e9bf42a2462
https://doi.org/10.1080/08820139.2018.1439505
https://doi.org/10.1080/08820139.2018.1439505
Autor:
Maarten L. van Roosmalen, Yueshuang Song, Tianxu Sun, Wei Kong, Chunlai Jiang, Dandan Wang, Tiejun Gu, Jingcai Lu, Kees Leenhouts, Yongge Wu, Hongjia Hou
Publikováno v:
Immunology Letters. 187:41-46
Pneumolysin (Ply) is an important virulence factor in pneumococcal infection and a conserved cholesterol-binding cytotoxin expressed by all serotypes of Streptococcus pneumoniae. We previously developed a highly detoxified Ply mutant designated Plym2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fa56cba21d2cd8d4ab9d952819ddde
https://doi.org/10.1016/j.imlet.2017.05.003
https://doi.org/10.1016/j.imlet.2017.05.003
Autor:
C. Russell Middaugh, Maarten L. van Roosmalen, Jae Hyun Kim, Wendy L. Picking, Ronald T. Toth, Prashant Kumar, Kees Leenhouts, William D. Picking, Shyamal P. Choudhari, Xiaotong Chen
Publikováno v:
Journal of Pharmaceutical Sciences. 104:4065-4073
Diarrhea caused by Shigella, Salmonella, and Yersinia is an important public health problem, but development of safe and effective vaccines against such diseases is challenging. A new antigen delivery platform called bacterium-like particles (BLPs) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a10e0dfc4d989acecdcdad2f9940f96
https://doi.org/10.1002/jps.24659
https://doi.org/10.1002/jps.24659
Autor:
Shannon J, Heine, Olga L, Franco-Mahecha, Khandra T, Sears, Cinthia B, Drachenberg, Maarten L, van Roosmalen, Kees, Leenhouts, Wendy L, Picking, Marcela F, Pasetti
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 202(7)
Yersinia enterocolitica causes a severe enteric infection in infants and young children. There is no vaccine approved for use in humans. We investigated the immunogenicity and protective capacity of Yersinia YopB, a conserved type III secretion syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e53559d7e6e53585929449f3f4a60d3
https://pubmed.ncbi.nlm.nih.gov/30787109
https://pubmed.ncbi.nlm.nih.gov/30787109
Autor:
William D. Picking, Xiaotong Chen, Shyamal P. Choudhari, Jae Hyun Kim, Wendy L. Picking, Kees Leenhouts, Maarten L. van Roosmalen, C. Russell Middaugh, Sangeeta B. Joshi, Jamie C. Greenwood
Publikováno v:
Journal of Pharmaceutical Sciences. 104:424-432
Bacterium-like particles (BLPs), derived from Lactococcus lactis , offer a self-adjuvanting delivery vehicle for subunit protein vaccines. Proteins can be specifically loaded onto the BLPs via a peptidoglycan anchoring (PA) domain. In this study, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193eb9cf3707d848b14ba567ca7bc65d
https://doi.org/10.1002/jps.24047
https://doi.org/10.1002/jps.24047
Autor:
Maarten L. van Roosmalen, Kees Leenhouts, Jean P Amorij, Anke Huckriede, Vinay Saluja, Henderik W. Frijlink, Wouter L. J. Hinrichs
Publikováno v:
Aaps journal, 12(2), 109-116. SPRINGER
The AAPS Journal
The AAPS Journal
Nasal administration of influenza vaccine has the potential to facilitate influenza control and prevention. However, when administered intranasally (i.n.), commercially available inactivated vaccines only generate systemic and mucosal immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c8578234b09584279461a80a4d44d9
https://doi.org/10.1208/s12248-009-9168-2
https://doi.org/10.1208/s12248-009-9168-2
Autor:
Girbe Buist, Maarten L. van Roosmalen, Anton Steen, Jolanda Neef, Mohamed El Khattabi, Sandrine A. L. Audouy, Tjibbe Bosma, Kees Leenhouts, Anneke Kuipers, Eduard Post, Oscar P. Kuipers, Rolf Kanninga, George T. Robillard, Jan Kok
Publikováno v:
Methods., 38(2), 144-149. ACADEMIC PRESS INC ELSEVIER SCIENCE
Mucosal immunization with subunit vaccines requires new types of antigen delivery vehicles and adjuvants for optimal immune responses. We have developed a non-living and non-genetically modified gram-positive bacterial delivery particle (GEM) that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31966be8a16fa6caa3c4832b258377b
https://research.rug.nl/en/publications/b9f48972-f3f9-4482-aa24-fd0ca434bf77
https://research.rug.nl/en/publications/b9f48972-f3f9-4482-aa24-fd0ca434bf77
Autor:
William C. Blackwelder, Kees Leenhouts, Maarten L. van Roosmalen, Marcela F. Pasetti, Shyamal P. Choudhari, Olga L. Franco-Mahecha, Shannon J. Heine, Xiaotong Chen, Wendy L. Picking
Publikováno v:
Immunology and cell biology
Shigella spp. are among the enteric pathogens with the highest attributable incidence of moderate-to-severe diarrhea in children under 5 years of age living in endemic areas. There are no vaccines available to prevent this disease. In this work, we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973f586ca374cee529341d4a7310b017
https://pubmed.ncbi.nlm.nih.gov/26054727
https://pubmed.ncbi.nlm.nih.gov/26054727