Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens

Autor: Maarten Eldering, Anaïs Bompard, Kazutoyo Miura, Will Stone, Isabelle Morlais, Anna Cohuet, Geert-Jan van Gemert, Patrick M. Brock, Sanna R. Rijpma, Marga van de Vegte-Bolmer, Wouter Graumans, Rianne Siebelink-Stoter, Dari F. Da, Carole A. Long, Merribeth J. Morin, Robert W. Sauerwein, Thomas S. Churcher, Teun Bousema

Publikováno v: Parasites & Vectors, Vol 10, Iss 1, Pp 1-10 (2017)

Abstract Background With the increasing interest in vaccines to interrupt malaria transmission, there is a demand for harmonization of current methods to assess Plasmodium transmission in laboratory settings. Potential vaccine candidates are currentl

Externí odkaz: https://doaj.org/article/04a1a119a28d46e6b50fa9eaf991961c

Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases

Autor: Petr Volf, Katerina Pruzinova, Matthew S. Tremblay, Robert W. Sauerwein, Arnab Chatterjee, Angelika Sturm, Baiyuan Yang, Teun Bousema, Neil M. Ferguson, Hans-Peter Duerr, Maarten Eldering, Graham P. Trevitt, John Wisler, Constantianus J. M. Koenraadt, Magdalena Jancarova, Koen J. Dechering, Pauline Ambrose, Rosemary Susan Lees, Hannah C Slater, Peter G. Schultz, Karin M. J. Koolen, Miglianico Marie

Publikováno v: Proceedings of the National Academy of Sciences USA, 115, 29, pp. E6920-E6926
Proceedings of the National Academy of Sciences USA, 115, E6920-E6926
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 115 (2018) 29
Proceedings of the National Academy of Sciences of the United States of America, 115(29), E6920-E6926
E6926
E6920

Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles, Ae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033c5c984b94ebd595f6932884570b5d
https://hdl.handle.net/2066/194398

Non-competitive resource exploitation within-mosquito shapes evolution of malaria virulence

Autor: Robert W. Sauerwein, Markus Gildenhard, Elena A. Levashina, Giulia Costa, Randall L. Lindquist, Anja E. Hauser, Volker Brinkmann, Christian Goosmann, Maarten Eldering

Malaria is a fatal human parasitic disease transmitted by a mosquito vector. The evolution of within-host malaria virulence has been the focus of many empirical and theoretical studies. However, the vector’s contribution to virulence evolution is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8304135db4c0daf23827673824e66abf

Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes

Autor: Maarten Eldering, Robert W. Sauerwein, Wouter Graumans, Will Roeffen, Marga van de Vegte-Bolmer, Luc Abate, Isabelle Morlais, Martijn W. Vos, Elena A. Levashina, Teun Bousema, Geert-Jan van Gemert, Rianne Siebelink-Stoter

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, pp.20440. ⟨10.1038/srep20440⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.20440. ⟨10.1038/srep20440⟩
Scientific Reports, 6

Anopheles gambiae s.s. mosquitoes are efficient vectors for Plasmodium falciparum, although variation exists in their susceptibility to infection. This variation depends partly on the thioester-containing protein 1 (TEP1) and TEP depletion results in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd8505724c79c0f46041e99a66341be
https://hal.umontpellier.fr/hal-02016600/file/srep20440.pdf

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays

Autor: Geert-Jan van Gemert, Robert W. Sauerwein, Teun Bousema, Chris Drakeley, Maarten Eldering, Will Roeffen, Will Stone, Wouter Graumans, Marga van de Vegte-Bolmer, Kjerstin Lanke, Rianne Siebelink-Stoter, Lynn Grignard

Publikováno v: Scientific Reports; Vol 3
Scientific Reports

Mosquito feeding assays are important in evaluations of malaria transmission-reducing interventions. The proportion of mosquitoes with midgut oocysts is commonly used as an outcome measure, but in natural low intensity infections the effect of oocyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4dc57051003d187322b5362b2dd23c