Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Maarten E Witte"'
Autor:
Carla Rodriguez-Mogeda, Melissa MJ van Gool, Richard van der Mast, Rutger Nijland, Zoë Keasberry, Lisanne van de Bovekamp, Myrthe AM van Delft, Carmen Picon, Richard Reynolds, Joep Killestein, Charlotte E Teunissen, Helga E de Vries, Marjolein van Egmond, Maarten E Witte
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Intrathecal synthesis of immunoglobulins (Igs) is a key hallmark of multiple sclerosis (MS). B cells are known to accumulate in the leptomeninges of MS patients and associate with pathology in the underlying cortex and a more severe disease
Externí odkaz:
https://doaj.org/article/d0785083e3a8472d80607cfbb25ef070
Autor:
Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese
Publikováno v:
eLife, Vol 10 (2021)
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue neurodegene
Externí odkaz:
https://doaj.org/article/d34d7f79b1524923b04c1e6c6a2626e7
Autor:
Carla Rodriguez-Mogeda, Zoë Y. G. J. van Lierop, Susanne M. A. van der Pol, Loet Coenen, Laura Hogenboom, Alwin Kamermans, Ernesto Rodriguez, Jack van Horssen, Zoé L. E. van Kempen, Bernard M. J. Uitdehaag, Charlotte E. Teunissen, Maarten E. Witte, Joep Killestein, Helga E. de Vries
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Recent studies suggest that extended interval dosing of ocrelizumab, an anti-B cell therapy, does not affect its clinical effectiveness in most patients with multiple sclerosis (MS). However, it remains to be established whether c
Externí odkaz:
https://doaj.org/article/3f86be80f38742afbf3232690c390a1c
Autor:
Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, Alwin Kamermans, Sandra Amor, Jack van Horssen, Maarten E. Witte, Gijs Kooij, Helga E. de Vries
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract The choroid plexus (CP) is strategically located between the peripheral blood and the cerebrospinal fluid, and is involved in the regulation of central nervous system (CNS) homeostasis. In multiple sclerosis (MS), demyelination and inflammat
Externí odkaz:
https://doaj.org/article/8c7ddcfe2bec45a086daa724750ab49d
Autor:
Carla Rodriguez-Mogeda, Sabela Rodríguez-Lorenzo, Jiji Attia, Jack van Horssen, Maarten E. Witte, Helga E. de Vries
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 800 (2022)
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) known for the manifestation of demyelinated lesions throughout the CNS, leading to neurodegeneration. To date, not all pathological mechanisms that drive disease p
Externí odkaz:
https://doaj.org/article/de593a967d3c4ae8aba5e13fc7eabf8f
Autor:
Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, Alwin Kamermans, Sandra Amor, Jack van Horssen, Maarten E. Witte, Gijs Kooij, Helga E. de Vries
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-1 (2020)
The original publication of this article [1] contained an incorrect author name. The correct and incorrect information is shown in this correction article. The original article has been updated.
Externí odkaz:
https://doaj.org/article/d13e733a7e3d4641966808ee221a53cc
Autor:
Jeroen Baardman, Sanne G.S. Verberk, Koen H.M. Prange, Michel van Weeghel, Saskia van der Velden, Dylan G. Ryan, Rob C.I. Wüst, Annette E. Neele, Dave Speijer, Simone W. Denis, Maarten E. Witte, Riekelt H. Houtkooper, Luke A. O’neill, Elena V. Knatko, Albena T. Dinkova-Kostova, Esther Lutgens, Menno P.J. de Winther, Jan Van den Bossche
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Summary: Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immune
Externí odkaz:
https://doaj.org/article/d4969ea3a1584cdbbc7e5b1d85f55612
Autor:
Carla Rodriguez-Mogeda, Sabela Rodríguez-Lorenzo, Jiji Attia, Jack van Horssen, Maarten E. Witte, Helga E. de Vries
Publikováno v:
Rodriguez-Mogeda, C, Rodríguez-Lorenzo, S, Attia, J, van Horssen, J, Witte, M E & de Vries, H E 2022, ' Breaching Brain Barriers : B Cell Migration in Multiple Sclerosis ', Biomolecules, vol. 12, no. 6, 800 . https://doi.org/10.3390/biom12060800, https://doi.org/10.3390/biom12060800
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) known for the manifestation of demyelinated lesions throughout the CNS, leading to neurodegeneration. To date, not all pathological mechanisms that drive disease p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6cc0fa222899e1590b437346dc6f4f
https://research.vumc.nl/en/publications/c846483d-a96b-450c-9294-abcf5004080a
https://research.vumc.nl/en/publications/c846483d-a96b-450c-9294-abcf5004080a
Autor:
Maarten E. Witte, John G.J.M. Bol, Wouter H. Gerritsen, Paul van der Valk, Benjamin Drukarch, Jack van Horssen, Micha M.M. Wilhelmus
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 3, Pp 445-452 (2009)
Parkin is implicated in the pathogenesis of Parkinson's disease. Furthermore, parkin targets misfolded proteins for degradation and protects cells against various forms of cellular stress, including unfolded-protein and oxidative stress. This points
Externí odkaz:
https://doaj.org/article/8244a30411234e8d9bd05be5a1a288fb
Autor:
Lydian Knoop, Alwin Kamermans, Susanne M. A. van der Pol, Svenja Kiljan, Marc Franssen, Geert J. Schenk, Carmen Picón, Jack van Horssen, Evelien Drost, Nicholas D. Mazarakis, Sandra Amor, Lynn van Olst, Richard Reynolds, Helga E. de Vries, Rachel E. James, Maarten E. Witte, Iliana Michailidou, Jeroen J. G. Geurts, Carla Rodriguez-Mogeda
Publikováno v:
Acta Neuropathologica, 141(6), 881-899. Springer Verlag
van Olst, L, Rodriguez Mogeda, C, Picon, C, Kiljan, S, James, R E, Kamermans, A, van der Pol, S M A, Knoop, L, Michailidou, I, Drost, E, Franssen, M, Schenk, G J, Geurts, J J G, Amor, S, Mazarakis, N D, van Horssen, J, de Vries, H E, Reynolds, R & Witte, M E 2021, ' Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration ', Acta Neuropathologica, vol. 141, no. 6, pp. 881-899 . https://doi.org/10.1007/s00401-021-02293-4
Acta Neuropathologica
van Olst, L, Rodriguez Mogeda, C, Picon, C, Kiljan, S, James, R E, Kamermans, A, van der Pol, S M A, Knoop, L, Michailidou, I, Drost, E, Franssen, M, Schenk, G J, Geurts, J J G, Amor, S, Mazarakis, N D, van Horssen, J, de Vries, H E, Reynolds, R & Witte, M E 2021, ' Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration ', Acta Neuropathologica, vol. 141, no. 6, pp. 881-899 . https://doi.org/10.1007/s00401-021-02293-4
Acta Neuropathologica
Meningeal inflammation strongly associates with demyelination and neuronal loss in the underlying cortex of progressive MS patients, thereby contributing significantly to clinical disability. However, the pathological mechanisms of meningeal inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0957b67feeac3b0e4dfd13e8b3902887
https://research.vumc.nl/en/publications/1f92b2d0-c8fa-4105-bbe6-f8f866702a82
https://research.vumc.nl/en/publications/1f92b2d0-c8fa-4105-bbe6-f8f866702a82