Výsledky vyhledávání - "Maarten C. Welling"

By-pass of the major aminofluorene-DNA adduct during in vivo replication of single- and double-stranded øX174 DNA treated with N-hydroxy-2-aminofluorene

Autor: E. Kriek, Maarten C. Welling, J. Retèl, Henk Loman, J.Gerard Westra, J.T. Lutgerink

Publikováno v: Carcinogenesis. 6:1501-1506

To examine the effects of aminofluorene-DNA adduct formation on the biological activity of DNA, single-stranded (ss) phi X174 DNA and phi X174 replicative form (RF) DNA were modified to different extents with 3H-labeled N-hydroxy-2-aminofluorene and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72717f8fc8183e9d9585ddb81e37f01
https://doi.org/10.1093/carcin/6.10.1501

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The biological activity of single-stranded ΦX174 DNA, modified by N-hydroxy-2-aminofluorene, is inhibited by guanine imidazole ring-opening of the major, non-lethal aminofluorene-DNA adduct

Autor: J. Retèl, J.G. Westra, E. Kriek, Maarten C. Welling, J.T. Lutgerink, Henk Loman

Publikováno v: Carcinogenesis. 7:1359-1364

The major aminofluorene-DNA derivative, found in the liver of rats after administration of the hepatocarcinogen N-acetyl-2-aminofluorene and identified as N-(deoxyguanosin-8-yl)-2-aminofluorene (dGuo-C8-AF), was introduced in different amounts in sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a829c029ccfeb9b77ce4cc23dfcc1d1
https://doi.org/10.1093/carcin/7.8.1359

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Measurement of O6-ethyldeoxyguanosine and N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene in DNA by high-sensitive enzyme immunoassays

Autor: A.M. Hagenaars, A.J. Kuipers, J. Nagel, E. Kriek, E. Scherer, G. Hermsen, C.J. Van Der Laken, Maarten C. Welling

Publikováno v: Carcinogenesis. 3(5)

Antibodies raised in rabbits against the bovine serum albumin conjugates of O6-ethylguanosine and N-(guanosin-8-yl)-N-acetyl-2-aminofluorene have been used to develop a high-sensitive enzyme-linked immunosorbent assay (HS-ELISA) for the quantificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86d1c10971302e066a588d255844c61
https://pubmed.ncbi.nlm.nih.gov/7094214

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Antibodies Specific for DNA Components Modified by Chemical Carcinogens and Their Binding Efficiency to DNA Modified in Vivo and in Vitro with the Corresponding Carcinogens

Autor: Michel J.X. Hillebrand, Maarten C. Welling, Frederik J. van Schooten, E. Kriek

Publikováno v: Chemical Carcinogenesis ISBN: 9781475796421

It is now well established that almost all carcinogens form a variety of reaction products with DNA, involving covalent binding to the various nucleophilic sites on all four DNA bases as well as the phosphate groups of DNA. Thus, even qualitative det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eb60b72ab086666daf28dbfc7504cd3
https://doi.org/10.1007/978-1-4757-9640-7_13

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