Catastrophic collapse can occur without early warning: examples of silent catastrophes in structured ecological models.

Autor: Maarten C Boerlijst, Thomas Oudman, André M de Roos

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e62033 (2013)

Catastrophic and sudden collapses of ecosystems are sometimes preceded by early warning signals that potentially could be used to predict and prevent a forthcoming catastrophe. Universality of these early warning signals has been proposed, but no for

Externí odkaz: https://doaj.org/article/2f8792764dfd4a79a436edea5b69b4c2

Effects of Random Mutations in the Human Immunodeficiency Virus Type 1 Transcriptional Promoter on Viral Fitness in Different Host Cell Environments

Autor: Tim van Opijnen, Ben Berkhout, Maarten C. Boerlijst

Publikováno v: Journal of Virology, 80(13), 6678-6685. American Society for Microbiology
Journal of virology, 80(13), 6678-6685. American Society for Microbiology

A mutation's effect on fitness or phenotype may in part depend on the interaction of the mutation with the environment. The resulting phenotype or fitness is important, since it determines the adaptive potential of a species. To date, most studies ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d801f52ed6ef8759cc6e24e0265cd6fe
https://doi.org/10.1128/jvi.02547-05

Role of avidity and breadth of the CD4 T cell response in prograssion to AIDS

Autor: Maarten C. Boerlijst, Rob J. de Boer, Hester Korthals Altes

Publikováno v: Proceedings of the Royal Society B-Biological Sciences, 273(1594), 1697-1704. Royal Society of London
Proceedings of the Royal Society B, 273, 1697. Royal Society Publishing

The great variability in the time between infection with HIV and the onset of AIDS has been the object of intense study. In the current work, we examine a mathematical model that focuses on the role of immune response variability between patients. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6031d80b8ba33d7e1f8a56b29b3d7ac4
https://hdl.handle.net/11245/1.262945

AIDS vaccines that allow HIV-1 to infect and escape immunologic control - A mathematic analysis of mass vaccination

Autor: Jaap Goudsmit, G. J. Weverling, Marijn van Ballegooijen, Johannes A. Bogaards, Maarten C. Boerlijst

Publikováno v: Journal of acquired immune deficiency syndromes (1999), 34(2), 214-220. Lippincott Williams and Wilkins
Bogaards, J A, Van Ballegooijen, M, Weverling, G J, Boerlijst, M C & Goudsmit, J 2003, ' AIDS vaccines that allow HIV-1 to infect and escape immunologic control : A mathematic analysis of mass vaccination ', Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 2, pp. 214-220 . https://doi.org/10.1097/00126334-200310010-00012
Journal of Acquired Immune Deficiency Syndromes, 34(2), 214-220

Cytotoxic T lymphocyte (CTL)-based HIV vaccine concepts shown to reduce viremia and postpone disease but not to prevent infection in monkeys are currently in human phase 1 trials. To evaluate the potential efficacy of vaccines that cannot prevent HIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e5c61cac2f4a81c61ab2bfb9aad0e4
https://doi.org/10.1097/00126334-200310010-00012

Spatial gradients enhance persistence of hypercycles

Autor: Pauline Hogeweg, Maarten C. Boerlijst

Publikováno v: Physica D: Nonlinear Phenomena. 88:29-39

In this paper we study a partial differential equation model of cyclic catalysis of replicating entities (i.e. a hypercycle). In the presence of a spatial gradient in the decay rate of molecules we observe spiral drift towards the region of faster ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::837ae3c103f8bd5eb95cfb817239f274
https://doi.org/10.1016/0167-2789(95)00178-7