Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maarouf Baghdadi"'
Autor:
Maarouf Baghdadi, Tobias Nespital, Carolina Monzó, Joris Deelen, Sebastian Grönke, Linda Partridge
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101902- (2024)
Objective: Rapamycin, a powerful geroprotective drug, can have detrimental effects when administered chronically. We determined whether intermittent treatment of mice can reduce negative effects while maintaining benefits of chronic treatment. Method
Externí odkaz:
https://doaj.org/article/a82a0bef98704f7ea031b10a51fa7346
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The Cre-loxP system has been used to generate cell-type specific mutations in mice, allowing researchers to investigate the underlying biological mechanisms of disease. However, the Cre-recombinase alone can induce phenotypes that confound c
Externí odkaz:
https://doaj.org/article/b028f22cecb945f2b689e00e34a8a555
Autor:
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J. Withers, Sebastian Grönke, Linda Partridge
Publikováno v:
Science Advances
Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in mice and causes tissue-specific changes in gene expression. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9200ccb47872327f7eac940736be0ab6
https://hdl.handle.net/21.11116/0000-000C-B955-4
https://hdl.handle.net/21.11116/0000-000C-B955-4
Autor:
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J. Withers, Sebastian Grönke, Linda Partridge
Reduced activity of the insulin/IGF signalling (IIS) network extends healthspan and lifespan in mammals and possibly humans. Loss of the Irs1 gene increases survival in mice and causes tissue-specific changes in gene expression. However, the tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2469f9766d948ab9d48ad5f1ec9fbdf6
https://doi.org/10.1101/2022.09.19.508502
https://doi.org/10.1101/2022.09.19.508502
Publikováno v:
Briefings in Functional Genomics
Many of the leading causes of death in humans, such as cardiovascular disease, type 2 diabetes and Alzheimer’s disease are influenced by biological mechanisms that become dysregulated with increasing age. Hence, by targeting these ageing-related me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c020d767eb874eeb7dc7c07b9cdc662
https://doi.org/10.1093/bfgp/elab005
https://doi.org/10.1093/bfgp/elab005
Autor:
Linda Partridge, Swati Parekh, Yvonne Hinze, Robin D. Dowell, Kat Folz-Donahue, Ignacio J. Tripodi, Monika Maleszewska, Andromachi Pouikli, Peter Tessarz, Andrea Mesaros, Patrick Giavalisco, Chrysa Nikopoulou, David A. Hoey, Maarouf Baghdadi
Publikováno v:
Nature Aging
Aging is accompanied by a general decline in the function of many cellular pathways. However, whether these are causally or functionally interconnected remains elusive. Here, we study the effect of mitochondrial–nuclear communication on stem cell a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6347e98aef56f1e4be26a13c61d8de
https://hdl.handle.net/21.11116/0000-000B-2D5B-E
https://hdl.handle.net/21.11116/0000-000B-2D5B-E
Publikováno v:
Encyclopedia of Gerontology and Population Aging ISBN: 9783319698922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804339b4d4b32c55264176770f8cf8f0
https://doi.org/10.1007/978-3-030-22009-9_726
https://doi.org/10.1007/978-3-030-22009-9_726
Autor:
Linda Partridge, Monika Maleszewska, Yvonne Hinze, Peter Tessarz, Robin D. Dowell, Ignacio J. Tripodi, Swati Parekh, Kat Folz-Donahue, Maarouf Baghdadi, Patrick Giavalisco, Chrysa Nikopoulou, Andrea Mesaros, Andromachi Pouikli
Ageing is accompanied by a general decline in the function of many cellular pathways, with metabolic alterations, epigenetic modifications, and stem cell exhaustion representing three important hallmarks of the ageing process. However, whether these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf9e83ffb0d40ccd1fb131b8b20e692
Autor:
Michiel Coesmans, Najaf Amin, Christian G. Bouwkamp, Aviva Nijburg, Timothy Wu, Maarouf Baghdadi, H. Berna Beverloo, Nilhan Gunhanlar, Guido J. Breedveld, Bas Lendemeijer, Veerle Bergink, P. Roberto Bakker, Carolyn D. Langen, Edwin Mientjes, Witte J.G. Hoogendijk, Ype Elgersma, Frans W. Verheijen, A.T. Spijker, André G. Uitterlinden, Simone Olgiati, Femke M.S. de Vrij, M. Arfan Ikram, Ton de Wit, Vincenzo Bonifati, Henning Tiemeier, Loes M. Olde Loohuis, Dan Cohen, Cornelia M. van Duijn, Rob M. Kok, Guy Shpak, Mehrnaz Ghazvini, Tonya White, P. M. Judith Haffmans, Meike W. Vernooij, Tracy Li, Erik Hoencamp, Marialuisa Quadri, Albert Hofman, Ben Distel, Joost Gribnau, Shreekara Gopalakrishna, Steven A. Kushner, Jacob A. S. Vorstman
Publikováno v:
Molecular Psychiatry, 24(5), 757-771. Nature Publishing Group
Molecular psychiatry, 24, 757-771. Nature Publishing Group
Molecular Psychiatry
Molecular psychiatry, 24, 757-771. Nature Publishing Group
Molecular Psychiatry
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47c11de95e90cc589d840a6752d3ce2
https://pure.eur.nl/en/publications/995aa584-ec6f-4e06-81d1-54836f7e439e
https://pure.eur.nl/en/publications/995aa584-ec6f-4e06-81d1-54836f7e439e
Autor:
Rayan Naser, Afaf Saliba, Dayana Hayek, Sawsan M. Al Lafi, Noël Ghanem, Carine Jaafar, Larissa Skaf, Renaud Vandenbosch, Maarouf Baghdadi, Saad Omais
Publikováno v:
Scientific Reports
Adult neural stem cells (aNSCs) are relatively quiescent populations that give rise to distinct neuronal subtypes throughout life, yet, at a very low rate and restricted differentiation potential. Thus, identifying the molecular mechanisms that contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc94935fac9de00845eaf998e57132ec