Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart

Autor: Francesca Del Gaudio, Dongli Liu, Maarja Andaloussi Mäe, Eike-Benjamin Braune, Emil M. Hansson, Qing-Dong Wang, Christer Betsholtz, Urban Lendahl

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The heart depends on a functional vasculature for oxygenation and transport of nutrients, and it is of interest to learn how primary impairment of the vasculature can indirectly affect cardiac function and heart morphology. Notch3-deficiency

Externí odkaz: https://doaj.org/article/12b2410e4eda4271b1548e478b597290

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research

Autor: Lars Muhl, Liqun He, Ying Sun, Maarja Andaloussi Mäe, Riikka Pietilä, Jianping Liu, Guillem Genové, Lei Zhang, Yuan Xie, Stefanos Leptidis, Giuseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsänen, Emil M. Hansson, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Taija Mäkinen, Xiao-Rong Peng, Yizhou Hu, Patrik Ernfors, Thomas D. Arnold, Kari Alitalo, Urban Lendahl, Christer Betsholtz

Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is impor-tant to learn where the SARS-CoV-2 receptor ACE2 is expressed. Here we mapped ACE2 expression during mouse postnatal develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48773163c4f779200f287930f67ceac5
http://hdl.handle.net/10138/345993

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.

Autor: Michael Vanlandewijck, Thibaud Lebouvier, Maarja Andaloussi Mäe, Khayrun Nahar, Simone Hornemann, David Kenkel, Sara I Cunha, Johan Lennartsson, Andreas Boss, Carl-Henrik Heldin, Annika Keller, Christer Betsholtz

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143407 (2015)

Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by progressive pericapillary calcifications, has recently been linked to heterozygous mutations in PDGFB and PDGFRB genes. Here, we functionally analyzed several o

Externí odkaz: https://doaj.org/article/fa59e83e7f19451c8403602659ddc266

Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells

Autor: Lars Muhl, Viktoria Kalna, Christine Tait-Burkard, Christer Betsholtz, Urban Lendahl, Samantha J. Griffiths, Liqun He, Maarja Andaloussi-Mäe, Jürgen Haas, Nicky M. Craig, Michela Noseda, Andrew H. Baker, Graeme M. Birdsey, Anna M. Randi, Alik Huseynov, Ian R McCracken, Claire Peghaire, Sarah Fletcher, Alison Daniels, Gaye Saginc

Publikováno v: Mccracken, I R, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N M, Griffiths, S J, Haas, J G, Tait-burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, A M 2021, ' Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.120.052824
McCracken, I, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N, Griffiths, S, Haas, J G, Tait-Burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, AM 2021, ' Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells ', Circulation, vol. 143, no. 8, pp. 865–868 . https://doi.org/10.1101/2020.12.02.391664, https://doi.org/10.1161/CIRCULATIONAHA.120.052824

A striking feature of severe COVID-19 is thrombosis in large as well as small vessels of multiple organs. This has led to the assumption that SARS-CoV-2 virus directly infects and damages the vascular endothelium. However, endothelial expression of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aa94feee0c5342e43995e3943c7a0e
https://hdl.handle.net/20.500.11820/3bc7226a-64ab-47ee-a209-60b325542bf6

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 - implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients

Autor: Liqun He, Maarja Andaloussi Mäe, Lars Muhl, Ying Sun, Riikka Pietilä, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Lei Zhang, Yuan Xie, Stefanos Leptidis, Giuseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsänen, Olivier Mirabeau, Emil Hansson, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz

Accumulating clinical observations suggest pathogenesis beyond viral pneumonia and its secondary consequences in COVID-19 patients. In particular, many patients develop profound hyperinflammation and hypercoagulopathy with disseminated thrombogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3397775b98e7a526555f144eae0dc907