Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Autor: Elisa Vázquez-Liébanas, Giuseppe Mocci, Weihan Li, Bàrbara Laviña, Avril Reddy, Claire O’Connor, Natalie Hudson, Zaher Elbeck, Ioannis Nikoloudis, Konstantin Gaengel, Michael Vanlandewijck, Matthew Campbell, Christer Betsholtz, Maarja Andaloussi Mäe

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113911- (2024)

Summary: Claudin-5 (CLDN5) is an endothelial tight junction protein essential for blood-brain barrier (BBB) formation. Abnormal CLDN5 expression is common in brain disease, and knockdown of Cldn5 at the BBB has been proposed to facilitate drug delive

Externí odkaz: https://doaj.org/article/d34577273d7342149fefcf704bebdf82

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Autor: Chris Greene, Nicole Hanley, Cristina R. Reschke, Avril Reddy, Maarja A. Mäe, Ruairi Connolly, Claire Behan, Eoin O’Keeffe, Isobel Bolger, Natalie Hudson, Conor Delaney, Michael A. Farrell, Donncha F. O’Brien, Jane Cryan, Francesca M. Brett, Alan Beausang, Christer Betsholtz, David C. Henshall, Colin P. Doherty, Matthew Campbell

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

The mechanisms underlying epilepsy development are not well understood. Here the authors show that loss of a key component of the so called blood-brain barrier drives seizures in mice and is also lost in humans with treatment resistant epilepsy

Externí odkaz: https://doaj.org/article/4e4b16153a6148c99d2bb1956b4675ce

A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature

Autor: Katrine Dahl Bjørnholm, Francesca Del Gaudio, Hao Li, Weihan Li, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Urban Lendahl, Christer Betsholtz, Per Nilsson, Helena Karlström, Michael Vanlandewijck

Publikováno v: Cell Rep Methods

Studying disease-related changes in the brain vasculature is warranted due to its crucial role in supplying oxygen and nutrients and removing waste and due to the anticipated vascular dysfunction in brain diseases. To this end, we have developed a pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca299cd940826f250fbbc162add5c40
https://doi.org/10.1016/j.crmeth.2023.100431

Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development

Autor: Annika Keller, Khayrun Nahar, Elisa Vazquez-Liebanas, Maarja Andaloussi Mäe, Christer Betsholtz, Giacomo Bertuzzi

Publikováno v: Journal of Cerebral Blood Flow & Metabolism

Platelet-derived growth factor B (PDGFB) released from endothelial cells is indispensable for pericyte recruitment during angiogenesis in embryonic and postnatal organ growth. Constitutive genetic loss-of-function of PDGFB leads to pericyte hypoplasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7d2456bbf723e5d5c3aeb01f630f68
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468325

Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells

Autor: Lars Muhl, Viktoria Kalna, Christine Tait-Burkard, Christer Betsholtz, Urban Lendahl, Samantha J. Griffiths, Liqun He, Maarja Andaloussi-Mäe, Jürgen Haas, Nicky M. Craig, Michela Noseda, Andrew H. Baker, Graeme M. Birdsey, Anna M. Randi, Alik Huseynov, Ian R McCracken, Claire Peghaire, Sarah Fletcher, Alison Daniels, Gaye Saginc

Publikováno v: Mccracken, I R, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N M, Griffiths, S J, Haas, J G, Tait-burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, A M 2021, ' Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.120.052824
McCracken, I, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N, Griffiths, S, Haas, J G, Tait-Burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, AM 2021, ' Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells ', Circulation, vol. 143, no. 8, pp. 865–868 . https://doi.org/10.1101/2020.12.02.391664, https://doi.org/10.1161/CIRCULATIONAHA.120.052824

A striking feature of severe COVID-19 is thrombosis in large as well as small vessels of multiple organs. This has led to the assumption that SARS-CoV-2 virus directly infects and damages the vascular endothelium. However, endothelial expression of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aa94feee0c5342e43995e3943c7a0e
https://hdl.handle.net/20.500.11820/3bc7226a-64ab-47ee-a209-60b325542bf6