OxLDL sensitizes platelets for increased formation of extracellular vesicles capable of finetuning macrophage gene expression

Autor: Katariina Maaninka, Maarit Neuvonen, Erja Kerkelä, Kati Hyvärinen, Mari Palviainen, Masood Kamali-Moghaddam, Antonio Federico, Dario Greco, Saara Laitinen, Katariina Öörni, Pia RM Siljander

Publikováno v: European Journal of Cell Biology, Vol 102, Iss 2, Pp 151311- (2023)

Platelet extracellular vesicles (PEVs) generated upon platelet activation may play a role in inflammatory pathologies such as atherosclerosis. Oxidized low-density lipoprotein (oxLDL), a well-known contributor to atherogenesis, activates platelets an

Externí odkaz: https://doaj.org/article/53441755532f4df7902743fa696d36a4

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles

Autor: Elisa Lázaro-Ibáñez, Maarit Neuvonen, Maarit Takatalo, Uma Thanigai Arasu, Cristian Capasso, Vincenzo Cerullo, Johng S. Rhim, Kirsi Rilla, Marjo Yliperttula, Pia R.-M. Siljander

Publikováno v: Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)

Extracellular vesicles (EVs), including microvesicles and exosomes, mediate intercellular signalling which has a profound role in cancer progression and in the development of metastasis. Internalisation of EVs can prompt functional changes in the rec

Externí odkaz: https://doaj.org/article/efc47de534dd473cb782a267f550cdc0

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication.

Autor: Maarit Neuvonen, Arunas Kazlauskas, Miika Martikainen, Ari Hinkkanen, Tero Ahola, Kalle Saksela

Publikováno v: PLoS Pathogens, Vol 7, Iss 11, p e1002383 (2011)

Among the four non-structural proteins of alphaviruses the function of nsP3 is the least well understood. NsP3 is a component of the viral replication complex, and composed of a conserved aminoterminal macro domain implicated in viral RNA synthesis,

Externí odkaz: https://doaj.org/article/468852f140644a40a1029d116a2dba4d

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells

Autor: Vladislav V. Verkhusha, Maarit Neuvonen, Konstantin G. Chernov, Ivonne Brock, Elina Ikonen

Publikováno v: Journal of Biological Chemistry. 292:8811-8822

Cholesterol oxidase (COase) is a bacterial enzyme catalyzing the first step in the biodegradation of cholesterol. COase is an important biotechnological tool for clinical diagnostics and production of steroid drugs and insecticides. It is also used f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20de6289fc0fefd7e5398f39318d6dc
https://doi.org/10.1074/jbc.m116.761718

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

Autor: Hélène Dutartre, Bruno Canard, Hélène Malet, Naomi L. Forrester, Nicolas Papageorgiou, Bruno Coutard, Ernest A. Gould, Xavier de Lamballerie, Alexander E. Gorbalenya, Tero Ahola, Maarit Neuvonen, François Ferron, Julien Lescar, Daniel Lafitte, Saïd Jamal

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2009, 83 (13), pp.6534-6545. ⟨10.1128/JVI.00189-09⟩
Journal of Virology, 2009, 83 (13), pp.6534-6545. ⟨10.1128/JVI.00189-09⟩

Macro domains (also called “X domains”) constitute a protein module family present in all kingdoms of life, including viruses of the Coronaviridae and Togaviridae families. Crystal structures of the macro domain from the Chikungunya virus (an “

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34171048dcd5be04dc49227ce07dbe6