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Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C ^+/- During Development.

Autor: Shafaattalab S; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Li AY; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Jayousi F; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Maaref Y; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Dababneh S; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada., Hamledari H; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Baygi DH; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Barszczewski T; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Ruprai B; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Jannati S; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Mechanical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Nagalingam R; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada., Cool AM; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA., Langa P; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA., Chiao M; Mechanical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Roston T; Division of Cardiology and Centre for Cardiovascular Innovation, The University of British Columbia 1081 Burrard Street, Level 4 Cardiology Vancouver, BC, V6Z 1Y6, Canada., Solaro RJ; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA., Sanatani S; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada., Toepfer C; University of Oxford, Oxford, UK., Lindert S; Mechanical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Lange P; Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC.; Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada., Tibbits GF; Cellular and Regenerative Medicine Centre, BC Children's Hospital Research Institute, Vancouver, BC, V5Z 4H4, Canada.; Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.; Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 13. Date of Electronic Publication: 2023 Aug 13.