Contemporary Zika Virus Isolates Induce More dsRNA and Produce More Negative-Strand Intermediate in Human Astrocytoma Cells

Autor: Trisha R. Barnard, Maaran M. Rajah, Selena M. Sagan

Publikováno v: Viruses, Vol 10, Iss 12, p 728 (2018)

The recent emergence and rapid geographic expansion of Zika virus (ZIKV) poses a significant challenge for public health. Although historically causing only mild febrile illness, recent ZIKV outbreaks have been associated with more severe neurologica

Externí odkaz: https://doaj.org/article/80e53ed4aa1741aca37f032dba2c94d2

Zika Virus: Emergence, Phylogenetics, Challenges, and Opportunities

Autor: Maaran M. Rajah, Stephanie A. Condotta, Ryan D. Pardy, Martin J. Richer, Selena M. Sagan

Publikováno v: ACS infectious diseases. 2(11)

Zika virus (ZIKV) is an emerging arthropod-borne pathogen that has recently gained notoriety due to its rapid and ongoing geographic expansion and its novel association with neurological complications. Reports of ZIKV-associated Guillain–Barre synd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc1edf714a92ddc9f106a0ba6f84d6b
https://pubmed.ncbi.nlm.nih.gov/27704772

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans.

Autor: Park S; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Bin NR; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Rajah M; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada., Kim B; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada., Chou TC; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Kang SY; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada., Sugita K; Division of Genetics and Development, Krembil Discovery Tower, University Health Network, Toronto, ON M5T 2S8, Canada., Parsaud L; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Smith M; Division of Signaling Biology, MaRS Toronto Medical Discovery Tower, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Monnier PP; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada Division of Genetics and Development, Krembil Discovery Tower, University Health Network, Toronto, ON M5T 2S8, Canada., Ikura M; Division of Genetics and Development, Krembil Discovery Tower, University Health Network, Toronto, ON M5T 2S8, Canada Division of Signaling Biology, MaRS Toronto Medical Discovery Tower, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada., Zhen M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Sugita S; Division of Fundamental Neurobiology, University Health Network, Toronto, ON M5T 2S8, Canada Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada ssugita@uhnres.utoronto.ca.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2016 Feb 15; Vol. 27 (4), pp. 669-85. Date of Electronic Publication: 2015 Dec 23.