Stereo-selective inhibition of spinal morphine tolerance and hyperalgesia by an ultra-low dose of the alpha-2-adrenoceptor antagonist efaroxan

Autor: Khem Jhamandas, Maaja Sutak, Catherine M. Cahill, Patrick Grenier, Brian Milne

Publikováno v: Milne, B; Jhamandas, K; Sutak, M; Grenier, P; & Cahill, CM. (2013). Stereo-selective inhibition of spinal morphine tolerance and hyperalgesia by an ultra-low dose of the alpha-2-adrenoceptor antagonist efaroxan. European Journal of Pharmacology, 702(1-3), 227-234. doi: 10.1016/j.ejphar.2013.01.022. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1sm240tt

Ultra-low doses of alpha-2 (α2)-adrenoceptor antagonists augment spinal morphine antinociception and inhibit tolerance, but the role of receptor specificity in these actions is unknown. We used the stereo-isomers of the α2adrenoceptor antagonist, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ba89192cffee533218f2d840c68e97
https://doi.org/10.1016/j.ejphar.2013.01.022

Low doses of α2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance

Autor: Khem Jhamandas, Brian Milne, Maaja Sutak, Catherine M. Cahill

Publikováno v: British Journal of Pharmacology. 155:1264-1278

Background and purpose: Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1f0bb00ec1a98d9a64987b3aa3aebf3
https://doi.org/10.1038/bjp.2008.353

Involvement of cannabinoid (CB1)-receptors in the development and maintenance of opioid tolerance

Autor: Maaja Sutak, Tuan Trang, Khem Jhamandas

Publikováno v: Neuroscience. 146:1275-1288

Sustained exposure to opioid agonists such as morphine increases levels of calcitonin gene-related peptide (CGRP) in the spinal dorsal horn, a response implicated in the development of opioid tolerance and physical dependence. Recent evidence suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca0246222591406bb77f9d83479ce2c
https://doi.org/10.1016/j.neuroscience.2007.02.031

Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal

Autor: Rémi Quirion, Khem Jhamandas, Tuan Trang, Maaja Sutak

Publikováno v: British Journal of Pharmacology. 140:295-304

1. This study investigated the role of spinal lipoxygenase (LOX) products in the induction and expression of opioid physical dependence using behavioural assessment of withdrawal and immunostaining for CGRP and Fos protein expression in the spinal co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0156e9c8356b1f1a41f844787ec07b0c
https://doi.org/10.1038/sj.bjp.0705440

Analgesia, enhancement of spinal morphine antinociception, and inhibition of tolerance by ultra-low dose of the α2A-adrenoceptor selective antagonist BRL44408

Autor: Catherine M. Cahill, Patrick Grenier, Brian Milne, Maaja Sutak, Khem Jhamandas

Ultra-low doses of non-selective α2-adrenoceptor antagonists augment acute spinal morphine antinociception and block morphine tolerance; however, the receptor involved in mediating these effects is currently unknown. Here, we used tail flick and paw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dce7943351f8d87bc94151a66826275
https://escholarship.org/uc/item/6gc826m1