Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Maaike van derLee"'
Autor:
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 8, Pp 1143-1156 (2023)
Abstract The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies. However, as quinidine is also a subst
Externí odkaz:
https://doaj.org/article/503a323dba2b45ac83fda9c9d5d71582
Autor:
Qinglian Zhai, Dirk Jan A. R. Moes, Teun vanGelder, Maaike van derLee, Jan‐Stephan Sanders, Frederike J. Bemelman, Johan W. deFijter, Kathrin Klein, Matthias Schwab, Jesse J. Swen
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract CYP3A4 activity shows considerable interindividual variability. Although studies indicate 60%–80% is heritable, common single nucleotide variants (SNVs) in CYP3A4 together only explain ~10%. Transcriptional factors, such as the testis‐sp
Externí odkaz:
https://doaj.org/article/cf902441beee46b8b8ebb244b07235fe
Autor:
Helena Leonie Hanae Loer, Denise Feick, Simeon Rüdesheim, Dominik Selzer, Matthias Schwab, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Thorsten Lehr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 724-738 (2023)
Abstract The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying ca
Externí odkaz:
https://doaj.org/article/8f442549019b44338f8e3c2b8a8de9ff
Autor:
Maaike van derLee, Jesse J. Swen
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 1, Pp 31-36 (2023)
Abstract In recent years, the use of artificial intelligence (AI) in health care has risen steadily, including a wide range of applications in the field of pharmacology. AI is now used throughout the entire continuum of pharmacology research and clin
Externí odkaz:
https://doaj.org/article/e4914a3493644e809884bcfb25071ec5