The Bigger Picture: Why Oral Mucosa Heals Better Than Skin

Autor: Maaike Waasdorp, Bastiaan P. Krom, Floris J. Bikker, Paul P. M. van Zuijlen, Frank B. Niessen, Susan Gibbs

Publikováno v: Biomolecules, Vol 11, Iss 8, p 1165 (2021)

Wound healing is an essential process to restore tissue integrity after trauma. Large skin wounds such as burns often heal with hypertrophic scarring and contractures, resulting in disfigurements and reduced joint mobility. Such adverse healing outco

Externí odkaz: https://doaj.org/article/016dee6c10374a19b888f1c64e4f4605

Pharmacological PAR-1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy

Autor: JanWillem Duitman, C. Arnold Spek, Sandrine Florquin, Maaike Waasdorp

Publikováno v: FASEB Journal, 33(10), 10966-10972. FASEB
Waasdorp, M, Florquin, S, Duitman, J & Spek, C A 2019, ' Pharmacological PAR-1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy ', FASEB Journal, vol. 33, no. 10, pp. 10966-10972 . https://doi.org/10.1096/fj.201900516R
FASEB journal, 33(10), 10966-10972. FASEB

Vorapaxar-dependent protease-activated receptor (PAR)-1 inhibition diminishes diabetic nephropathy in experimental type 1 diabetes. As most patients with diabetic nephropathy suffer from type 2 diabetes, the aim of this study was to investigate wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35053a0a1d18d9de02ef513b5c967ee
https://doi.org/10.1096/fj.201900516r

CXCL4 drives fibrosis by promoting several key cellular and molecular processes

Autor: Alsya J. Affandi, Tiago Carvalheiro, Andrea Ottria, Judith J. de Haan, Maike A.D. Brans, Maarten M. Brandt, Ralph G. Tieland, Ana P. Lopes, Beatriz Malvar Fernández, Cornelis P.J. Bekker, Maarten van der Linden, Maili Zimmermann, Barbara Giovannone, Catharina G.K. Wichers, Samuel Garcia, Michael de Kok, Giuseppina Stifano, Yan Juan Xu, M. Anna Kowalska, Maaike Waasdorp, Caroline Cheng, Susan Gibbs, Saskia C.A. de Jager, Joel A.G. van Roon, Timothy R.D.J. Radstake, Wioleta Marut

Publikováno v: Cell Reports, 38(1):110189. Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernandez, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189
Cell Reports, 38(1). Cell Press
Affandi, A J, Carvalheiro, T, Ottria, A, de Haan, J J, Brans, M A D, Brandt, M M, Tieland, R G, Lopes, A P, Fernández, B M, Bekker, C P J, van der Linden, M, Zimmermann, M, Giovannone, B, Wichers, C G K, Garcia, S, de Kok, M, Stifano, G, Xu, Y J, Kowalska, M A, Waasdorp, M, Cheng, C, Gibbs, S, de Jager, S C A, van Roon, J A G, Radstake, T R D J & Marut, W 2022, ' CXCL4 drives fibrosis by promoting several key cellular and molecular processes ', Cell Reports, vol. 38, no. 1, 110189 . https://doi.org/10.1016/j.celrep.2021.110189

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and strongly correlates with sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3b28b93aeccba36fb11cbf7a1fecc6
https://pubmed.ncbi.nlm.nih.gov/34986347

The Bigger Picture: Why Oral Mucosa Heals Better Than Skin

Autor: Paul P. M. van Zuijlen, Susan Gibbs, Frank B. Niessen, Bastiaan P. Krom, Maaike Waasdorp, Floris J. Bikker

Publikováno v: Waasdorp, M, Krom, B P, Bikker, F J, van Zuijlen, P P M, Niessen, F B & Gibbs, S 2021, ' The bigger picture : Why oral mucosa heals better than skin ', Biomolecules, vol. 11, no. 8, 1165 . https://doi.org/10.3390/biom11081165
Biomolecules
Biomolecules, Vol 11, Iss 1165, p 1165 (2021)

© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Wound healing is an essential process to restore tissue integrity after trauma. Large skin wounds such as burns often heal with hypertrophic scarring and contractures, resulting in disfigureme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c11dc6f236cd0b9741bad70cc5e601
https://doi.org/10.3390/biom11081165

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

Autor: Tom van der Poll, Farhad Rezaee, Cong Lin, Keren Borensztajn, C. Arnold Spek, Maaike Waasdorp, Kun Shi

Publikováno v: Oncotarget, 6(34), 35304-35314. Impact Journals LLC
Oncotarget, 6(34), 35304-35314. Impact Journals
Oncotarget

Idiopathic pulmonary fibrosis (IPF) is a destructive disease in part resulting from premature or mature cellular aging. Protease-activated receptor-1 (PAR-1) recently emerged as a critical component in the context of fibrotic lung diseases. Therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5bdc0c44703b54141ad333ff6045a5
https://doi.org/10.18632/oncotarget.6095