Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maaike Hoekstra"'
Autor:
Harsha D Devalla, Roselle Gélinas, Elhadi H Aburawi, Abdelaziz Beqqali, Philippe Goyette, Christian Freund, Marie‐A Chaix, Rafik Tadros, Hui Jiang, Antony Le Béchec, Jantine J Monshouwer‐Kloots, Tom Zwetsloot, Georgios Kosmidis, Frédéric Latour, Azadeh Alikashani, Maaike Hoekstra, Jurg Schlaepfer, Christine L Mummery, Brian Stevenson, Zoltan Kutalik, Antoine AF de Vries, Léna Rivard, Arthur AM Wilde, Mario Talajic, Arie O Verkerk, Lihadh Al‐Gazali, John D Rioux, Zahurul A Bhuiyan, Robert Passier
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 12, Pp 1390-1408 (2016)
Abstract Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐exome sequencing (WES) was carried out on patients from three different families that presented with life‐threatening arrhythmias and high risk of
Externí odkaz:
https://doaj.org/article/fbd3c37951794a57a006bfdb37a6a0d0
Autor:
Vincent Portero, Sridharan Rajamani, Maaike Hoekstra, Simona Casini, Luiz Belardinelli, Arthur A.M. Wilde, Arie O. Verkerk, Connie R. Bezzina, Marieke W. Veldkamp, Isabella Mengarelli, Carol Ann Remme
Publikováno v:
Cardiovascular research, 113(7), 829-838. Oxford University Press
Aims Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the electrophysiological effects of GS-458967 (GS967), a potent, selective inhibitor of INaL, in an ove
Autor:
Dirk J. Duncker, Daphne Merkus, Vincent J. de Beer, Maaike Hoekstra, M. Harold Laughlin, Shawn B. Bender, Zhichao Zhou, Daphne de Wijs-Meijler
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 306(5), L442-L452. American Physiological Society
Both phosphodiesterase 5 (PDE5) inhibition and endothelin (ET) receptor blockade have been shown to induce pulmonary vasodilation. However, little is known about the effect of combined blockade of these two vasoconstrictor pathways. Since nitric oxid
Autor:
Philippe Goyette, Jantine Monshouwer-Kloots, Elhadi H. Aburawi, Marie A. Chaix, Zoltán Kutalik, Arthur A.M. Wilde, Tom Zwetsloot, Brian Stevenson, Azadeh Alikashani, Zahurul A. Bhuiyan, John D. Rioux, Christine L. Mummery, Christian Freund, Jurg Schlaepfer, Robert Passier, Georgios Kosmidis, Hui Jiang, Antoine A.F. de Vries, Abdelaziz Beqqali, Maaike Hoekstra, Arie O. Verkerk, Antony Le Béchec, Rafik Tadros, Mario Talajic, Lihadh Al-Gazali, Lena Rivard, Roselle Gélinas, Harsha D. Devalla, Frédéric Latour
Publikováno v:
EMBO molecular medicine, vol. 8, no. 12, pp. 1390-1408
EMBO molecular medicine, 8(12), 1390-1408. Wiley-Blackwell
Devalla, H D, Gélinas, R, Aburawi, E H, Beqqali, A, Goyette, P, Freund, C, Chaix, M-A, Tadros, R, Jiang, H, Le Béchec, A, Monshouwer-Kloots, J J, Zwetsloot, T, Kosmidis, G, Latour, F, Alikashani, A, Hoekstra, M, Schlaepfer, J, Mummery, C L, Stevenson, B, Kutalik, Z, de Vries, A AF, Rivard, L, Wilde, A AM, Talajic, M, Verkerk, A O, Al-Gazali, L, Rioux, J D, Bhuiyan, Z A & Passier, R 2016, ' TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT ', EMBO Molecular Medicine, vol. 8, no. 12, pp. 1390-1408 . https://doi.org/10.15252/emmm.201505719
EMBO Molecular Medicine, 8(12), 1390-1408
EMBO Molecular Medicine
EMBO molecular medicine, 8(12), 1390-1408. Wiley-Blackwell
Devalla, H D, Gélinas, R, Aburawi, E H, Beqqali, A, Goyette, P, Freund, C, Chaix, M-A, Tadros, R, Jiang, H, Le Béchec, A, Monshouwer-Kloots, J J, Zwetsloot, T, Kosmidis, G, Latour, F, Alikashani, A, Hoekstra, M, Schlaepfer, J, Mummery, C L, Stevenson, B, Kutalik, Z, de Vries, A AF, Rivard, L, Wilde, A AM, Talajic, M, Verkerk, A O, Al-Gazali, L, Rioux, J D, Bhuiyan, Z A & Passier, R 2016, ' TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT ', EMBO Molecular Medicine, vol. 8, no. 12, pp. 1390-1408 . https://doi.org/10.15252/emmm.201505719
EMBO Molecular Medicine, 8(12), 1390-1408
EMBO Molecular Medicine
Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole‐exome sequencing (WES) was carried out on patients from three different families that presented with life‐threatening arrhythmias and high risk of sudden ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc321d0326c0649feeedfd6fcc1dde6
https://serval.unil.ch/notice/serval:BIB_EB060DB2BDA6
https://serval.unil.ch/notice/serval:BIB_EB060DB2BDA6
Autor:
Dirk J. Duncker, Daphne Merkus, Maaike Hoekstra, Vincent J. de Beer, Veemal Hemradj, Zhichao Zhou, Fen Gao
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology, 302(8), H1747-H1755. American Physiological Society
Zhou Z, Hemradj V, de Beer VJ, Gao F, Hoekstra M, Merkus D, Duncker DJ. Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise. Am J Physiol Heart Circ Physiol 302: H1747-H1755, 201
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology, 298(6), H1976-H1985. American Physiological Society
de Beer VJ, de Graaff HJ, Hoekstra M, Duncker DJ, Merkus D. Integrated control of pulmonary vascular tone by endothelin and angiotensin II in exercising swine depends on gender. Am J Physiol Heart Circ Physiol 298: H1976-H1985, 2010. First published
Autor:
Vincent Portero, Maaike Hoekstra, Arie O Verkerk, Isabella Mengarelli, Richard P Davis, Christian Freund, Connie R Bezzina, Luiz Belardinelli, Sridharan Rajamani, Marieke W Veldkamp, Carol Ann Remme
Publikováno v:
Circulation. 130
Background and Aim: Selective inhibition of cardiac late sodium current (I Na,L ) is an emerging target in the treatment of ventricular arrhythmias. The electrophysiological effects of GS967, a potent I Na,L inhibitor, were investigated in an overlap
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Frontiers in Physiology
Frontiers in Physiology
Cardiac arrhythmias are a major cause of morbidity and mortality. In younger patients, the majority of sudden cardiac deaths have an underlying Mendelian genetic cause. Over the last 15 years, enormous progress has been made in identifying the distin
Autor:
Connie R. Bezzina, Maaike Hoekstra, Christian Freund, Daniela C.F. Salvatori, Dorien Ward-van Oostwaard, Cathelijne W. van den Berg, Arthur A.M. Wilde, Arie O. Verkerk, Christine L. Mummery, Carol Ann Remme, Simona Casini, Richard P. Davis, Cheryl Dambrot
Publikováno v:
Circulation, 125(25), 3079
Circulation, 125(25), 3079-+. Lippincott Williams and Wilkins
Circulation, 125(25), 3079-91
Circulation, 125(25), 3079-+. Lippincott Williams and Wilkins
Circulation, 125(25), 3079-91
Background— Pluripotent stem cells (PSCs) offer a new paradigm for modeling genetic cardiac diseases, but it is unclear whether mouse and human PSCs can truly model both gain- and loss-of-function genetic disorders affecting the Na + current ( I Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe29fa857960587b18b73ab011f8eb8b
http://hdl.handle.net/1887/97344
http://hdl.handle.net/1887/97344
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology, 298(3), H921-H929. American Physiological Society
During exercise, β-feedforward coronary vasodilation has been shown to contribute to the matching of myocardial oxygen supply with the demand of the myocardium. Since both β1- and β2-adrenoceptors are present in the coronary microvasculature, we i