Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Maaike G.J.M. van Bergen"'
1
Akademický článek
Abnormal Platelet Counts and Clonal Hematopoiesis in the General Population
Autor: Priscilla Kamphuis, Maaike G.J.M. van Bergen, Isabelle A. van Zeventer, Aniek O. de Graaf, Avinash G. Dinmohamed, Jonas B. Salzbrunn, Jan Jacob Schuringa, Bert A. van der Reijden, Gerwin Huls, Joop H. Jansen
Publikováno v: HemaSphere, Vol 7, Iss 1, p e821 (2023)
Clonal hematopoiesis (CH) is defined by the presence of somatic mutations that may cause clonal expansion of hematopoietic cells. Here, we investigated the association between platelet count abnormalities, CH and consequences on overall survival and
Externí odkaz: https://doaj.org/article/7ac6b58cd0d6499e879bd5e536edeca0
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2
Akademický článek
Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets
Autor: Rinske van Oorschot, Marten Hansen, Johanna M. Koornneef, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Floris P.J. van Alphen, Carmen van der Zwaan, Joost H.A. Martens, Michiel Vermeulen, Pascal W.T.C. Jansen, Marijke P.A. Baltissen, Britta A.P. Laros-van Gorkom, Hans Janssen, Joop H. Jansen, Marieke von Lindern, Alexander B. Meijer, Emile van den Akker, Bert A. van der Reijden
Publikováno v: Haematologica, Vol 104, Iss 7 (2019)
Dominant-negative mutations in the transcription factor Growth Factor Independence-1B (GFI1B), such as GFI1BQ287*, cause a bleeding disorder characterized by a plethora of megakaryocyte and platelet abnormalities. The deregulated molecular mechanisms
Externí odkaz: https://doaj.org/article/fa460826edfb42dbb79b809d6ce5fa66
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4
CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1
Autor: Marten Hansen, Esther Tijchon, Laura Jussen, Pascal W. T. C. Jansen, Luan Nguyen, Guoqiang Yi, Jonathan Bond, Michiel Vermeulen, Bert A. van der Reijden, Joost H.A. Martens, Emile van den Akker, Maaike G.J.M. van Bergen, Amit Mandoli, Gaëlle Cordonnier, Bowon Kim
Publikováno v: Blood Cancer Journal, Vol 9, Iss 3, Pp 1-13 (2019)
Blood Cancer Journal, 9, 33
Blood Cancer Journal
Blood cancer journal, 9(3):33. Nature Publishing Group
Blood Cancer Journal, 9, 3, pp. 33
The inv(16) acute myeloid leukemia-associated CBFβ-MYH11 fusion is proposed to block normal myeloid differentiation, but whether this subtype of leukemia cells is poised for a unique cell lineage remains unclear. Here, we surveyed the functional con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700acae5b654a82e9a9bdd5289960f87
http://link.springer.com/article/10.1038/s41408-019-0194-8
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5
Characterization of a genomic region 8 kb downstream of GFI1B associated with myeloproliferative neoplasms
Autor: Marijke P. Baltissen, Joop H. Jansen, Michiel Vermeulen, Evelyn Tönnissen, Ellen Stevens-Linders, Pascal W.T.C. Jansen, Kornelia Neveling, Rinske van Oorschot, Amit Mandoli, Saskia M. Bergevoet, Bert A. van der Reijden, Joost H.A. Martens, Maaike G.J.M. van Bergen, Aniek O. de Graaf, Frank Preijers
Publikováno v: Biochimica et Biophysica Acta. Molecular Basis of Disease, 1867, 12
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1867
A genomic locus 8 kb downstream of the transcription factor GFI1B (Growth Factor Independence 1B) predisposes to clonal hematopoiesis and myeloproliferative neoplasms. One of the most significantly associated polymorphisms in this region is rs621940-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e81fbf0c3360fb28b648e869cbef449
https://repository.ubn.ru.nl/handle/2066/237643
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7
Targeting the GFI1/1B-CoREST Complex in Acute Myeloid Leukemia
Autor: Maaike G.J.M. van Bergen, Bert A. van der Reijden
Publikováno v: Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology
One of the hallmarks of acute myeloid leukemia (AML) is a block in cellular differentiation. Recent studies have shown that small molecules targeting Lysine Specific Demethylase 1A (KDM1A) may force the malignant cells to terminally differentiate. KD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a47bf3c2b016285b2f4ed578c5f560
https://pubmed.ncbi.nlm.nih.gov/31649884
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8
Association of a Haplotype in the NR3C2 Gene, Encoding the Mineralocorticoid Receptor, With Chronic Central Serous Chorioretinopathy
Autor: Eiko K. de Jong, Paula Scholz, Carel B. Hoyng, Anneke I. den Hollander, Rosa L. Schellevis, Camiel J. F. Boon, Sascha Fauser, Myrte B. Breukink, Onno C. Meijer, Lebriz Altay, Maaike G.J.M. van Bergen, Elon H. C. van Dijk
Publikováno v: JAMA Ophthalmology, 135(5), 446-451
Jama Ophthalmology, 135, 446-451
Jama Ophthalmology, 135, 5, pp. 446-451
Item does not contain fulltext Importance: Chronic central serous chorioretinopathy (cCSC) is a chorioretinal disease with unknown disease etiology. The glucocorticoid receptor and the mineralocorticoid receptor, 2 glucocorticoid-binding receptors, m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1be09db9e6fc165502e4f9b41834b7f
https://hdl.handle.net/1887/114752
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