Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Maaike E de Backer"'
Autor:
Rob J A Nabuurs, Kim S Rutgers, Mick M Welling, Athanasios Metaxas, Maaike E de Backer, Maarten Rotman, Brian J Bacskai, Mark A van Buchem, Silvère M van der Maarel, Louise van der Weerd
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38284 (2012)
This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits characteristic for Alzheimer's disease and cerebral amyloid angiopathy.
Externí odkaz:
https://doaj.org/article/345936b88cb54209aa94fbd068f64428
Autor:
Louise van der Weerd, Albert D. Windhorst, Athanasios Metaxas, Mark Overhand, Mick M. Welling, Sarah Hafith, Wim Jiskoot, Rob J.A. Nabuurs, Adrianus M. C. H. van den Nieuwendijk, Maaike E. de Backer, Varsha V. Kapoerchan, Herman S. Overkleeft, Mark A. van Buchem
Publikováno v:
Bioorganic and Medicinal Chemistry, 24(23), 6139-6148
Bioorganic and Medicinal Chemistry, 24(23), 6139-6148. Elsevier Limited
Nabuurs, R J A, Kapoerchan, V V, Metaxas, A, Hafith, S, de Backer, M, Welling, M M, Jiskoot, W, van den Nieuwendijk, A M C H, Windhorst, A D, Overkleeft, H S, van Buchem, M A, Overhand, M & van der Weerd, L 2016, ' Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds ', Bioorganic and Medicinal Chemistry, vol. 24, no. 23, pp. 6139-6148 . https://doi.org/10.1016/j.bmc.2016.05.022
Bioorganic and Medicinal Chemistry, 24(23), 6139-6148. Elsevier Limited
Nabuurs, R J A, Kapoerchan, V V, Metaxas, A, Hafith, S, de Backer, M, Welling, M M, Jiskoot, W, van den Nieuwendijk, A M C H, Windhorst, A D, Overkleeft, H S, van Buchem, M A, Overhand, M & van der Weerd, L 2016, ' Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds ', Bioorganic and Medicinal Chemistry, vol. 24, no. 23, pp. 6139-6148 . https://doi.org/10.1016/j.bmc.2016.05.022
Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer's disease (AD). Partly because of their planar structure several bis-styrylbenzenes have been previously reported as potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365063b4bf0a0ae018a5ea2bd3be16bd
http://hdl.handle.net/1887/112175
http://hdl.handle.net/1887/112175
Autor:
Maarten Rotman, Maaike E. de Backer, Mick M. Welling, Anton Bunschoten, Silvère M. van der Maarel, Jaap Rip, Louise van der Weerd, Mark A. van Buchem, Pieter J. Gaillard, Rob J.A. Nabuurs
Publikováno v:
Journal of Controlled Release, 203, 40-50
Treatment of neurodegenerative disorders such as Alzheimer's disease is hampered by the blood-brain barrier (BBB). This tight cerebral vascular endothelium regulates selective diffusion and active transport of endogenous molecules and xenobiotics int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8fd285552d2e94c8ac5775020490b
https://hdl.handle.net/1887/101871
https://hdl.handle.net/1887/101871
Autor:
Athanasios Metaxas, Mark Overhand, Varsha V. Kapoerchan, Louise van der Weerd, Mick M. Welling, Wim Jiskoot, Hermen S. Overkleeft, Mark A. van Buchem, Sanne de Jongh, Rob J.A. Nabuurs, Albert D. Windhorst, Maaike E. de Backer
Publikováno v:
Nabuurs, R J A, Kapoerchan, V V, Metaxas, A, de Jongh, S, de Backer, M, Welling, M M, Jiskoot, W, Windhorst, A D, Overkleeft, H S, van Buchem, M A, Overhand, M & van der Weerd, L 2014, ' Polyfluorinated bis-styrylbenzenes as amyloid-beta plaque binding ligands ', Bioorganic and Medicinal Chemistry, vol. 22, no. 8, pp. 2469-2481 . https://doi.org/10.1016/j.bmc.2014.02.054
Bioorganic and Medicinal Chemistry, 22(8), 2469-2481. Elsevier Limited
Bioorganic and Medicinal Chemistry, 22(8), 2469-2481
Bioorganic and Medicinal Chemistry, 22(8), 2469-2481. Elsevier Limited
Bioorganic and Medicinal Chemistry, 22(8), 2469-2481
Detection of cerebral β-amyloid (Aβ) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. To further explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db78ba489b36de42ce9cae748820d62a
https://hdl.handle.net/1887/107029
https://hdl.handle.net/1887/107029