Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Maaike, Alaerts"'
Autor:
Hanne M. Boen, Bert Vandendriessche, Jolien Schippers, Laura Rabaut, Aleksandra Nijak-Paeske, Peter Ponsaerts, Emeline M. Van Craenenbroeck, Bart Loeys, Maaike Alaerts
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103536- (2024)
Truncating variants in TTN (TTNtv) are present in 15–25 % of patients with idiopathic dilated cardiomyopathy. Interestingly, the pathogenicity of TTNtv seems to be linked to their location within the gene. More proximal I-band TTNtv (TTNtvI) harbou
Externí odkaz:
https://doaj.org/article/c3299bc2be0e424f95b05a7926882f59
Autor:
Hanne M. Boen, Maaike Alaerts, Inge Goovaerts, Johan B. Saenen, Constantijn Franssen, Anne Vorlat, Tom Vermeulen, Hein Heidbuchel, Lut Van Laer, Bart Loeys, Emeline M. Van Craenenbroeck
Publikováno v:
Cardio-Oncology, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Background Variants in cardiomyopathy genes have been identified in patients with cancer therapy-related cardiac dysfunction (CTRCD), suggesting a genetic predisposition for the development of CTRCD. The diagnostic yield of genetic testing i
Externí odkaz:
https://doaj.org/article/d722bd93cc5b4cb3bf0e63ce250ce1f0
Autor:
Hanne M. Boen, Maaike Alaerts, Lut Van Laer, Johan B. Saenen, Inge Goovaerts, Jarl Bastianen, Pieter Koopman, Philippe Vanduynhoven, Elke De Vuyst, Michael Rosseel, Hein Heidbuchel, Emeline M. Van Craenenbroeck, Bart Loeys
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundVariants in the MYBPC3 gene are a frequent cause of hypertrophic cardiomyopathy (HCM) but display a large phenotypic heterogeneity. Founder mutations are often believed to be more benign as they prevailed despite potential negative selectio
Externí odkaz:
https://doaj.org/article/ff57bde99f3543aea920e69875af395f
Autor:
Amir Kirolos, Todd D. Swarthout, Andrew A. Mataya, Farouck Bonomali, Comfort Brown, Jacquline Msefula, Naor Bar-Zeev, Pui-Ying Iroh Tam, Maaike Alaerts, Sithembile Bilima, Robert S. Heyderman, Neil French
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Introduction The introduction of PCV13 to the Malawi infant immunization schedule in 2011 has been associated with reduced disease from Streptococcus pneumoniae. Improved understanding of serotypes with high invasive potential can guide futu
Externí odkaz:
https://doaj.org/article/63167f6b39844ccaba2eed1a4eeaad19
Autor:
Ewa Sieliwonczyk, Bert Vandendriessche, Charlotte Claes, Evy Mayeur, Maaike Alaerts, Philip Holmgren, Tycho Canter Cremers, Dirk Snyders, Bart Loeys, Dorien Schepers
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Despite numerous prior attempts to improve knock-in (KI) efficiency, the introduction of precise base pair substitutions by the CRISPR-Cas9 technique in zebrafish remains challenging. In our efforts to generate KI zebrafish models of human C
Externí odkaz:
https://doaj.org/article/a80db3a6daa9481ea82d1423965402c5
Autor:
Ewa Sieliwonczyk, Maaike Alaerts, Eline Simons, Dirk Snyders, Aleksandra Nijak, Bert Vandendriessche, Dorien Schepers, Dogan Akdeniz, Emeline Van Craenenbroeck, Katleen Knaepen, Laura Rabaut, Hein Heidbuchel, Lut Van Laer, Johan Saenen, Alain J. Labro, Bart Loeys
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract Background The c.1124_1127delTTCA p.(Ile375Argfs*43) pathogenic variant is the most frequently identified molecular defect in the KCNQ1 gene in the cardiogenetics clinic of the Antwerp University Hospital. This variant was observed in nine f
Externí odkaz:
https://doaj.org/article/ec0bef1929b34672b754c194513f25b6
Autor:
Joe Davis Velchev, Aline Verstraeten, Josephina Meester, Peter Ponsaerts, Julie Richer, Maaike Alaerts, Bart Loeys
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102932- (2022)
Loeys-Dietz Syndrome (LDS) is an autosomal dominant connective tissue disorder. The major hallmark of LDS is thoracic aortic aneurysm and dissection (TAAD). We generated an induced pluripotent stem cell (iPSC) line of a severely affected LDS patient
Externí odkaz:
https://doaj.org/article/703b49f9f6ef45e5b994ba6d6da347e9
Autor:
Bert Vandendriessche, Ewa Sieliwonczyk, Maaike Alaerts, Bart L. Loeys, Dirk Snyders, Dorien Schepers
Publikováno v:
Hearts, Vol 1, Iss 3, Pp 181-199 (2020)
Inherited cardiac arrhythmias contribute substantially to sudden cardiac death in the young. The underlying pathophysiology remains incompletely understood because of the lack of representative study models and the labour-intensive nature of electrop
Externí odkaz:
https://doaj.org/article/ac8a49636556499f988e55bd186300be
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102719- (2022)
Brugada syndrome (BrS) is an inherited primary electrical disorder of the heart. 25% of BrS patients carry a mutation in the SCN5A gene, encoding the cardiac specific voltage-gated sodium channel Nav1.5. Here we report two iPSC lines (BBANTWi006-A, B
Externí odkaz:
https://doaj.org/article/750ceb2bc53a4910b4fc4be6bd8fbd9e
Autor:
Aleksandra Nijak, Eline Simons, Bert Vandendriessche, Dieter Van de Sande, Erik Fransen, Ewa Sieliwończyk, Ilse Van Gucht, Emeline Van Craenenbroeck, Johan Saenen, Hein Heidbuchel, Peter Ponsaerts, Alain J. Labro, Dirk Snyders, Winnok De Vos, Dorien Schepers, Maaike Alaerts, Bart L. Loeys
Publikováno v:
Biology Open, Vol 11, Iss 2 (2022)
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive platform for cardiovascular research. Patient-specific iPSC-CMs are very useful for studying disease development, and bear potential for disease diagnostics, pr
Externí odkaz:
https://doaj.org/article/d433d6b4ecc94dee8781298307b06178