P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

Autor: Mª José Queipo, Juan C. Gil-Redondo, Verónica Morente, Felipe Ortega, Mª Teresa Miras-Portugal, Esmerilda G. Delicado, Raquel Pérez-Sen

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2018)

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play a central role in the intracellular signaling of P2X7 nucleotide receptors in neurons and glial cells. Fine spatio-temporal tuning of mitogen-activated protein (MAP) kinases is essential to

Externí odkaz: https://doaj.org/article/4077c3e9a86346a789eddbb2ff23f086

Neuroprotection Mediated by P2Y13 Nucleotide Receptors in Neurons

Autor: Raquel Pérez-Sen, Mª José Queipo, Verónica Morente, Felipe Ortega, Esmerilda G. Delicado, Mª Teresa Miras-Portugal

Publikováno v: Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 160-168 (2015)

ADP-specific P2Y13 receptor constitutes one of the most recently identified nucleotide receptor and the understanding of their physiological role is currently under investigation. Cerebellar astrocytes and granule neurons provide excellent models to

Externí odkaz: https://doaj.org/article/1ec1c1a596fe47edaf2b3337c10760c6

P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

Autor: Esmerilda G. Delicado, Verónica Morente, Felipe Ortega, Raquel Pérez-Sen, Mª José Queipo, Juan Carlos Gil-Redondo, Ma Teresa Miras-Portugal

Publikováno v: Frontiers in Molecular Neuroscience
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Frontiers in Molecular Neuroscience, Vol 10 (2018)

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play a central role in the intracellular signaling of P2X7 nucleotide receptors in neurons and glial cells. Fine spatio-temporal tuning of mitogen-activated protein (MAP) kinases is essential to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a34cc375137ad1fabc3ea52c28814cb
https://pubmed.ncbi.nlm.nih.gov/29375309

P2X7and P2Y13purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes

Autor: Antonio R. Artalejo, Yolanda Gutiérrez-Martín, Ma Teresa Miras-Portugal, Luz María G. Carrasquero, Esmerilda G. Delicado, Diego Bustillo

Publikováno v: Journal of Neurochemistry. 110:879-889

Previous work has established the presence of functional P2X(7) subunits in rat cerebellar astrocytes, which after stimulation with 3'-O-(4-benzoyl)benzoyl ATP (BzATP) evoked morphological changes that were not reproduced by any other nucleotide. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8625c4868180c4f792c8548f4da4b4be
https://doi.org/10.1111/j.1471-4159.2009.06179.x

Existence of high and low affinity dinucleotides pentaphosphate-induced calcium responses in individual synaptic terminals and lack of correlation with the distribution of P2X1–7 subunits

Autor: Rosa Gómez-Villafuertes, Patricia Marín-García, Ma Teresa Miras-Portugal, Jesús Sánchez-Nogueiro

Publikováno v: Neurochemistry International. 50:628-641

Individual analysis of synaptic terminals calcium responses, induced by dinucleotides pentaphosphate, Ap 5 A or Gp 5 G, demonstrates the presence of two main groups considering the concentration required for stimulation. The first group corresponds t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ecdea261674a2fb7bfaa03241c5ab6
https://doi.org/10.1016/j.neuint.2006.12.007