Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Maša Sterle"'
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Akademický článek
New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
Autor: Matjaž Weiss, Elena M. Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh
Publikováno v: Frontiers in Chemistry, Vol 9 (2021)
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins
Externí odkaz: https://doaj.org/article/bed20003ff6f4e85991d320f8a84b5ec
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3
Hydrogen-bonding ability of Noyori–Ikariya catalysts enables stereoselective access to CF$_3$-substituted syn-1,2-diols via dynamic kinetic resolution
Autor: Maša Sterle, Matej Huš, Matic Lozinšek, Anamarija Zega, Andrej Emanuel Cotman
Publikováno v: ACS catalysis, vol. 13, no. 9, pp. 6242-6248, 2023.
Stereopure CF$_3$-substituted syn-1,2-diols were prepared via the reductive dynamic kinetic resolution of the corresponding racemic α-hydroxyketones in HCO$_2$H/Et$_3$N. (Het)aryl, benzyl, vinyl, and alkyl ketones are tolerated, delivering products
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb53ef41cc7bd3f529a02e6323ed2b3
https://repozitorij.uni-lj.si/Dokument.php?id=170723&dn=
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4
Catalytic Stereoconvergent Synthesis of Homochiral β-CF3, β-SCF3, and β-OCF3 Benzylic Alcohols
Autor: Andrej Emanuel Cotman, Pavel A. Dub, Maša Sterle, Matic Lozinšek, Jaka Dernovšek, Živa Zajec, Anamarija Zega, Tihomir Tomašič, Dominique Cahard
Publikováno v: ACS organic & inorganic Au, vol. 2, no. 5, 2022.
ACS Organic & Inorganic Au
ACS Organic & Inorganic Au, 2022, 2 (5), pp.396-404. ⟨10.1021/acsorginorgau.2c00019⟩
International audience; We describe an efficient catalytic strategy for enantio- and diastereoselective synthesis of homochiral β-CF3, β-SCF3, and β-OCF3 benzylic alcohols. The approach is based on dynamic kinetic resolution (DKR) with Noyori–Ik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e099aaf3ecb2e7659016157da40bcf
https://doi.org/10.1021/acsorginorgau.2c00019
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5
Discovery and hit-to-lead optimization of benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas aeruginosa
Autor: Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Daniela Secci, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin Mašič, Tihomir Tomašič, Diarmaid Hughes, Douglas L. Huseby, Sha Cao, Linnéa Garoff, Talía Berruga Fernández, Paraskevi Giachou, Lisa Crone, Ivailo Simoff, Richard Svensson, Bryndis Birnir, Sergiy V. Korol, Zhe Jin, Francisca Vicente, Maria C. Ramos, Mercedes de la Cruz, Björn Glinghammar, Lena Lenhammar, Sara R. Henderson, Julia E. A. Mundy, Anthony Maxwell, Clare E. M. Stevenson, David M. Lawson, Guido V. Janssen, Geert Jan Sterk, Danijel Kikelj
Publikováno v: Journal of medicinal chemistry, vol. 66, no. 2, 2023.
Journal of medicinal chemistry, str. 1380-1425 : Ilustr., Vol. 66, no. 2, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, 66(2), 1380-1425. American Chemical Society
Cotman, A E, Durcik, M, Benedetto Tiz, D, Fulgheri, F, Secci, D, Sterle, M, Možina, Š, Skok, Ž, Zidar, N, Zega, A, Ilaš, J, Peterlin Mašič, L, Tomašič, T, Hughes, D, Huseby, D L, Cao, S, Garoff, L, Berruga Fernández, T, Giachou, P, Crone, L, Simoff, I, Svensson, R, Birnir, B, Korol, S V, Jin, Z, Vicente, F, Ramos, M C, De La Cruz, M, Glinghammar, B, Lenhammar, L, Henderson, S R, Mundy, J E A, Maxwell, A, Stevenson, C E M, Lawson, D M, Janssen, G V, Sterk, G J & Kikelj, D 2023, ' Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa ', Journal of medicinal chemistry, vol. 66, no. 2, pp. 1380-1425 . https://doi.org/10.1021/acs.jmedchem.2c01597
We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant bacteria. Starting from DNA gyrase inhibitor 1, we identified compound 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20d28e0e61c3b400f08f6903958d25f
https://repozitorij.uni-lj.si/Dokument.php?id=166579&dn=
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6
Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks
Autor: Frédéric R. Leroux, Maša Sterle, Janez Ilaš, Thomas Guérin, Martina Durcik, Lucija Peterlin Mašič, Daniela Secci, Gilles Hanquet, Davide Benedetto Tiz, Tihomir Tomašič, Andrej Emanuel Cotman, Nace Zidar, Federica Fulgheri, Štefan Možina, Ivana Kovačević, Anamarija Zega, Danijel Kikelj
Publikováno v: ACS Omega, Vol 6, Iss 14, Pp 9723-9730 (2021)
ACS Omega
ACS Omega, ACS Publications, 2021, 6 (14), pp.9723-9730. ⟨10.1021/acsomega.1c00331⟩
International audience; A practical access to four new halogen-substituted pyrrole building blocks was realized in two to five synthetic steps from commercially available starting materials. The target compounds were prepared on a 50 mg to 1 g scale,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd365d8e8c8eb6997e3533f33378a2ed
https://doaj.org/article/9ba5d039df7149c1b22ceb9e931835a8
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7
Homochiral β-CF3, -SCF3 and -OCF3 secondary alcohols: catalytic stereoconvergent synthesis, bioactivity and flexible crystals
Autor: Andrej Emanuel Cotman, Pavel A. Dub, Maša Sterle, Matic Lozinšek, Jaka Dernovšek, Živa Zajec, Tihomir Tomašič, Dominique Cahard
An optimized catalytic protocol for enantio- and diastereoselective reduction of racemic α-CF3, α-SCF3 and α-OCF3 aryl ketones is described. The reaction involves a dynamic kinetic resolution (DKR) based on ruthenium catalyzed Noyori–Ikariya asy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11f6b119f07fea28166b78fd9b25141a
https://doi.org/10.26434/chemrxiv-2022-0dn37
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8
New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
Autor: Marko Anderluh, Cyril Balsollier, Elena M. Loi, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Matjaž Weiss, Maša Sterle
Publikováno v: Frontiers in Chemistry
Frontiers in Chemistry, 9, 1. Frontiers Media S.A.
Frontiers in Chemistry, Vol 9 (2021)
Frontiers in chemistry, vol. 9, pp. 1-8, 2021.
Frontiers in chemistry, str. 1-8, Vol. 9, 2021
COBISS-ID: 1647919
O-GlcNAcylation is an important posttranslational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5714a3cb0765cdf4c141ff748c5b8c
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